Cargando…

Boosting the Antibacterial Activity of Azithromycin on Multidrug-Resistant Escherichia coli by Efflux Pump Inhibition Coupled with Outer Membrane Permeabilization Induced by Phenylalanine-Arginine β-Naphthylamide

The global spread of multidrug-resistant (MDR) bacteria increases the demand for the discovery of new antibiotics and adjuvants. Phenylalanine-arginine β-naphthylamide (PAβN) is an inhibitor of efflux pumps in Gram-negative bacteria, such as the AcrAB-TolC complex in Escherichia coli. We aimed to ex...

Descripción completa

Detalles Bibliográficos
Autores principales:	Al-Marzooq, Farah, Ghazawi, Akela, Daoud, Lana, Tariq, Saeed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218020/ https://www.ncbi.nlm.nih.gov/pubmed/37240007 http://dx.doi.org/10.3390/ijms24108662

Ejemplares similares

The Efflux Inhibitor Phenylalanine-Arginine Beta-Naphthylamide (PAβN) Permeabilizes the Outer Membrane of Gram-Negative Bacteria
por: Lamers, Ryan P., et al.
Publicado: (2013)

Discerning the role of polymyxin B nonapeptide in restoring the antibacterial activity of azithromycin against antibiotic-resistant Escherichia coli
por: Al-Marzooq, Farah, et al.
Publicado: (2022)

Effect of azithromycin and phenylalanine-arginine beta-naphthylamide on quorum sensing and virulence factors in clinical isolates of Pseudomonas aeruginosa
por: Elsheredy, Amel, et al.
Publicado: (2021)

Phenylalanine-arginine β-naphthylamide could enhance neomycin-sensitivity on Riemerella anatipestifer in vitro and in vivo
por: Liu, Shiqi, et al.
Publicado: (2023)

Elucidating the effect of iron acquisition systems in Klebsiella pneumoniae on susceptibility to the novel siderophore-cephalosporin cefiderocol
por: Daoud, Lana, et al.
Publicado: (2022)

Efflux Pump Inhibitor Phenylalanine-Arginine Β-Naphthylamide Effect on the Minimum Inhibitory Concentration of Imipenem in Acinetobacter baumannii Strains Isolated From Hospitalized Patients in Shahid Motahari Burn Hospital, Tehran, Iran
por: Gholami, Mehrdad, et al.
Publicado: (2015)

Proof of an Outer Membrane Target of the Efflux Inhibitor Phe-Arg-β-Naphthylamide from Random Mutagenesis
por: Schuster, Sabine, et al.
Publicado: (2019)

Effect of Phenylalanine–Arginine Beta-Naphthylamide on the Values of Minimum Inhibitory Concentration of Quinolones and Aminoglycosides in Clinical Isolates of Acinetobacter baumannii
por: Plasencia-Rebata, Stefany, et al.
Publicado: (2023)

Bark extract of Cassia sieberiana DC. (Caesalpiniaceae) displayed good antibacterial activity against MDR gram-negative phenotypes in the presence of phenylalanine-arginine β-naphthylamide
por: Ambadiang, Marilene M. M., et al.
Publicado: (2020)

Natural outer membrane permeabilizers boost antibiotic action against irradiated resistant bacteria
por: Farrag, Hala A., et al.
Publicado: (2019)

Tripartite efflux pumps: energy is required for dissociation, but not assembly or opening of the outer membrane channel of the pump
por: Janganan, Thamarai K, et al.
Publicado: (2013)

Mitochondrial outer membrane permeabilization at the single molecule level
por: Dadsena, Shashank, et al.
Publicado: (2021)

Biochemistry of Bacterial Multidrug Efflux Pumps
por: Kumar, Sanath, et al.
Publicado: (2012)

Microbial Primer: Multidrug efflux pumps
por: Siasat, Pauline Ann, et al.
Publicado: (2023)

Efflux Pump Antibiotic Binding Site Mutations Are Associated with Azithromycin Nonsusceptibility in Clinical Neisseria gonorrhoeae Isolates
por: Ma, Kevin C., et al.
Publicado: (2020)

Modulation of Mitochondrial Outer Membrane Permeabilization and Apoptosis by Ceramide Metabolism
por: Rego, António, et al.
Publicado: (2012)

Azithromycin Resistance through Interspecific Acquisition of an Epistasis-Dependent Efflux Pump Component and Transcriptional Regulator in Neisseria gonorrhoeae
por: Wadsworth, Crista B., et al.
Publicado: (2018)

Focus on the Outer Membrane Factor OprM, the Forgotten Player from Efflux Pumps Assemblies
por: Phan, Gilles, et al.
Publicado: (2015)

Clonality, outer-membrane proteins profile and efflux pump in KPC- producing Enterobacter sp. in Brazil
por: Rosa, Juliana Ferraz, et al.
Publicado: (2017)

A noncanonical chaperone interacts with drug efflux pumps during their assembly into bacterial outer membranes
por: Stubenrauch, Christopher J., et al.
Publicado: (2022)

Multidrug Efflux Pumps in Staphylococcus aureus: an Update
por: Costa, Sofia Santos, et al.
Publicado: (2013)

RND multidrug efflux pumps: what are they good for?
por: Alvarez-Ortega, Carolina, et al.
Publicado: (2013)

Tripartite assembly of RND multidrug efflux pumps
por: Daury, Laetitia, et al.
Publicado: (2016)

Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
por: Nishino, Kunihiko, et al.
Publicado: (2021)

Opening of the Outer Membrane Protein Channel in Tripartite Efflux Pumps Is Induced by Interaction with the Membrane Fusion Partner
por: Janganan, Thamarai K., et al.
Publicado: (2011)

Spread of Efflux Pump Overexpressing-Mediated Fluoroquinolone Resistance and Multidrug Resistance in Pseudomonas aeruginosa by using an Efflux Pump Inhibitor
por: Adabi, Maryam, et al.
Publicado: (2015)

The Role of Arginine-Phenylalanine-Amide-Related Peptides in Mammalian Reproduction
por: Salehi, Mohammad Saied, et al.
Publicado: (2015)

Identification of a multidrug efflux pump in Flavobacterium johnsoniae
por: Clark, Sarah E., et al.
Publicado: (2009)

Structural basis for the blockade of MATE multidrug efflux pumps
por: Radchenko, Martha, et al.
Publicado: (2015)

Crystal Structure of Escherichia coli CusC, the Outer Membrane Component of a Heavy Metal Efflux Pump
por: Kulathila, Rithika, et al.
Publicado: (2011)

Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells
por: Toriyama, Kazutoshi, et al.
Publicado: (2021)

Cationic Surfactants Based on Arginine-Phenylalanine and Arginine-Tryptophan: Synthesis, Aggregation Behavior, Antimicrobial Activity, and Biodegradation
por: Pérez, Lourdes, et al.
Publicado: (2022)

Raptinal bypasses BAX, BAK, and BOK for mitochondrial outer membrane permeabilization and intrinsic apoptosis
por: Heimer, Sina, et al.
Publicado: (2019)

Metabolic remodeling precedes mitochondrial outer membrane permeabilization in human glioma xenograft cells
por: Ponnala, Shivani, et al.
Publicado: (2021)

Molecular Dynamics Computer Simulations of Multidrug RND Efflux Pumps
por: Ruggerone, Paolo, et al.
Publicado: (2013)

Structure of the AcrAB-TolC multidrug efflux pump
por: Du, Dijun, et al.
Publicado: (2014)

The nature and epidemiology of OqxAB, a multidrug efflux pump
por: Li, Jun, et al.
Publicado: (2019)

Current Advances in Developing Inhibitors of Bacterial Multidrug  Efflux Pumps
por: Mahmood, Hannah Y., et al.
Publicado: (2016)

Bacterial Multidrug Efflux Pumps at the Frontline of Antimicrobial Resistance: An Overview
por: Huang, Lulu, et al.
Publicado: (2022)

Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors
por: Gaurav, Amit, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_of2i5q3879n878c512fk4phnd4