Loss of Primary Cilia Potentiates BRAF/MAPK Pathway Activation in Rhabdoid Colorectal Carcinoma: A Series of 21 Cases Showing Ciliary Rootlet CoiledCoil (CROCC) Alterations

A rhabdoid colorectal tumor (RCT) is a rare cancer with aggressive clinical behavior. Recently, it has been recognized as a distinct disease entity, characterized by genetic alterations in the SMARCB1 and Ciliary Rootlet Coiled-Coil (CROCC). We here investigate the genetic and immunophenotypic profi...

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Detalles Bibliográficos
Autores principales: Remo, Andrea, Grillo, Federica, Mastracci, Luca, Simbolo, Michele, Fassan, Matteo, Cecchini, Maria Paola, Miscio, Giuseppe, Sassano, Antonio, Parente, Paola, Vanoli, Alessandro, Sabella, Giovanna, Giordano, Guido, Urso, Emanuele Damiano, Cerulo, Luigi, Scarpa, Aldo, Fiorica, Francesco, Pancione, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218031/
https://www.ncbi.nlm.nih.gov/pubmed/37239344
http://dx.doi.org/10.3390/genes14050984

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