Cargando…

Rhein Induces Oral Cancer Cell Apoptosis and ROS via Suppresse AKT/mTOR Signaling Pathway In Vitro and In Vivo

Oral cancer remains the leading cause of death worldwide. Rhein is a natural compound extracted from the traditional Chinese herbal medicine rhubarb, which has demonstrated therapeutic effects in various cancers. However, the specific effects of rhein on oral cancer are still unclear. This study aim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Haibo, Ma, Lei, Kim, Eungyung, Yi, Junkoo, Huang, Hai, Kim, Hyeonjin, Raza, Muhammad Atif, Park, Sijun, Jang, Soyoung, Kim, Kirim, Kim, Sung-Hyun, Lee, Youngkyun, Kim, Eunkyong, Ryoo, Zae Young, Kim, Myoung Ok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218067/ https://www.ncbi.nlm.nih.gov/pubmed/37239855 http://dx.doi.org/10.3390/ijms24108507

Ejemplares similares

Rhein Suppresses Colorectal Cancer Cell Growth by Inhibiting the mTOR Pathway In Vitro and In Vivo
por: Zhang, Haibo, et al.
Publicado: (2021)

Silibinin induces oral cancer cell apoptosis and reactive oxygen species generation by activating the JNK/c-Jun pathway
por: Zhang, Haibo, et al.
Publicado: (2023)

Costunolide Induces Apoptosis via the Reactive Oxygen Species and Protein Kinase B Pathway in Oral Cancer Cells
por: Huang, Hai, et al.
Publicado: (2021)

Overexpression of cathepsin S exacerbates lupus pathogenesis through upregulation TLR7 and IFN-α in transgenic mice
por: Lee, Jinhee, et al.
Publicado: (2021)

Overexpression of Lin28a Aggravates Psoriasis-Like Phenotype by Regulating the Proliferation and Differentiation of Keratinocytes
por: Jang, Soyeon, et al.
Publicado: (2021)

20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo
por: Zhang, Haibo, et al.
Publicado: (2022)

Effects of Sangju Honey on Oral Squamous Carcinoma Cells
por: Yee, Nangwon, et al.
Publicado: (2022)

Ginger-derived compounds exert in vivo and in vitro anti-asthmatic effects by inhibiting the T-helper 2 cell-mediated allergic response
por: Kim, Eungyung, et al.
Publicado: (2022)

Protective Effect of GIP against Monosodium Glutamate-Induced Ferroptosis in Mouse Hippocampal HT-22 Cells through the MAPK Signaling Pathway
por: Ko, Jiwon, et al.
Publicado: (2022)

Rhein Inhibits Autophagy in Rat Renal Tubular Cells by Regulation of AMPK/mTOR Signaling
por: Tu, Yue, et al.
Publicado: (2017)

JAZF1 heterozygous knockout mice show altered adipose development and metabolism
por: Jeong, Jain, et al.
Publicado: (2021)

Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo
por: Huang, Hai, et al.
Publicado: (2021)

Overexpression of hepatic serum amyloid A1 in mice increases IL-17-producing innate immune cells and decreases bone density
por: Choi, Minjee, et al.
Publicado: (2021)

Beneficial effects of 6-shogaol on hyperglycemia, islet morphology and apoptosis in some tissues of streptozotocin-induced diabetic mice
por: Yi, Jun-Koo, et al.
Publicado: (2019)

hMAGEA2 promotes progression of breast cancer by regulating Akt and Erk1/2 pathways
por: Park, Song, et al.
Publicado: (2017)

Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
por: Kim, Hanseong, et al.
Publicado: (2015)

ROS, Klotho and mTOR in cardiorenal aging
por: Daneshgar, Nastaran, et al.
Publicado: (2020)

Anti-inflammatory effects of a methanol extract of Dictamnus dasycarpus Turcz. root bark on imiquimod-induced psoriasis
por: Choi, Minjee, et al.
Publicado: (2019)

Imatinib and GNF-5 Exhibit an Inhibitory Effect on Growth of Hepatocellar Carcinoma Cells by Downregulating S-phase Kinase-associated Protein 2
por: Zhang, Haibo, et al.
Publicado: (2020)

Quercetin Regulates Sestrin 2-AMPK-mTOR Signaling Pathway and Induces Apoptosis via Increased Intracellular ROS in HCT116 Colon Cancer Cells
por: Kim, Guen Tae, et al.
Publicado: (2013)

AMPK–mTOR Signaling and Cellular Adaptations in Hypoxia
por: Chun, Yoomi, et al.
Publicado: (2021)

Mechanisms of amino acid sensing in mTOR signaling pathway
por: Kim, Eunjung
Publicado: (2009)

Non-Thermal Plasma Induces Antileukemic Effect Through mTOR Ubiquitination
por: Kim, Sun-Yong, et al.
Publicado: (2020)

Targeting mTOR and Metabolism in Cancer: Lessons and Innovations
por: Magaway, Cedric, et al.
Publicado: (2019)

Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4(+) T cells
por: Jeong, Jiung, et al.
Publicado: (2023)

Promotion of Ovarian Follicle Growth following mTOR Activation: Synergistic Effects of AKT Stimulators
por: Cheng, Yuan, et al.
Publicado: (2015)

Rhein Meeting Program
por: The HiLumi LHC Collaboration
Publicado: (2014)

Brain size is controlled by the mammalian target of rapamycin (mTOR) in mice
por: Kim, Woo-Yang
Publicado: (2015)

Myricetin Inhibits Angiogenesis by Inducing Apoptosis and Suppressing PI3K/Akt/mTOR Signaling in Endothelial Cells
por: Kim, Gi Dae
Publicado: (2017)

Apoptotic Effects of Xanthium strumarium via PI3K/AKT/mTOR Pathway in Hepatocellular Carcinoma
por: Kim, Juyoung, et al.
Publicado: (2019)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Anti-inflammatory activity of rhein isolated from the flowers of Cassia fistula L. and possible underlying mechanisms
por: Antonisamy, Paulrayer, et al.
Publicado: (2019)

Activation of the Renal PI3K/Akt/mTOR Signaling Pathway in a DOCA-Salt Model of Hypertension
por: Ma, Seong Kwon, et al.
Publicado: (2012)

Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells
por: Liu, Xihong, et al.
Publicado: (2019)

Chrysin induces autophagy through the inactivation of the ROS-mediated Akt/mTOR signaling pathway in endometrial cancer
por: He, Yu, et al.
Publicado: (2021)

Inhibition of Migration and Invasion by Tet-1 Overexpression in Human Lung Carcinoma H460 Cells
por: Park, Si Jun, et al.
Publicado: (2016)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Increased Phosphorylation of PI3K/Akt/mTOR in the Obstructed Kidney of Rats with Unilateral Ureteral Obstruction
por: Ma, Seong Kwon, et al.
Publicado: (2013)

Azadirachtin Attenuates Lipopolysaccharide-Induced ROS Production, DNA Damage, and Apoptosis by Regulating JNK/Akt and AMPK/mTOR-Dependent Pathways in Rin-5F Pancreatic Beta Cells
por: John, Annie, et al.
Publicado: (2021)

The Effects of Exogenous Lactate Administration on the IGF1/Akt/mTOR Pathway in Rat Skeletal Muscle
por: Kyun, Sunghwan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_p4e0t0o3lvj0a3qivkjr54pg3u