POLE-Mutant Colon Cancer Treated with PD-1 Blockade Showing Clearance of Circulating Tumor DNA and Prolonged Disease-Free Interval

Colon cancer with high microsatellite instability is characterized by a high tumor mutational burden and responds well to immunotherapy. Mutations in polymerase ɛ, a DNA polymerase involved in DNA replication and repair, are also associated with an ultra-mutated phenotype. We describe a case where a...

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Detalles Bibliográficos
Autores principales: Bikhchandani, Mihir, Amersi, Farin, Hendifar, Andrew, Gangi, Alexandra, Osipov, Arsen, Zaghiyan, Karen, Atkins, Katelyn, Cho, May, Aguirre, Francesca, Hazelett, Dennis, Alvarez, Rocio, Zhou, Lisa, Hitchins, Megan, Gong, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218075/
https://www.ncbi.nlm.nih.gov/pubmed/37239414
http://dx.doi.org/10.3390/genes14051054

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