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Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury
The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218145/ https://www.ncbi.nlm.nih.gov/pubmed/37240148 http://dx.doi.org/10.3390/ijms24108805 |
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author | Wang, Zufeng Luo, Chengliang Zhou, Edward W. Sandhu, Aaron F. Yuan, Xiaojing Williams, George E. Cheng, Jialu Sinha, Bharati Akbar, Mohammed Bhattacharya, Pallab Zhou, Shuanhu Song, Byoung-Joon Wang, Xin |
author_facet | Wang, Zufeng Luo, Chengliang Zhou, Edward W. Sandhu, Aaron F. Yuan, Xiaojing Williams, George E. Cheng, Jialu Sinha, Bharati Akbar, Mohammed Bhattacharya, Pallab Zhou, Shuanhu Song, Byoung-Joon Wang, Xin |
author_sort | Wang, Zufeng |
collection | PubMed |
description | The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well understood and the identification of the comorbidity state markers is significantly challenging. This review summarizes the main characteristics of comorbidity between AUD and PTSD (AUD/PTSD) and highlights the significance of a comprehensive understanding of the molecular toxicology and pathophysiological mechanisms of AUD/PTSD, particularly following TBI, with a focus on the role of metabolomics, inflammation, neuroendocrine, signal transduction pathways, and genetic regulation. Instead of a separate disease state, a comprehensive examination of comorbid AUD and PTSD is emphasized by considering additive and synergistic interactions between the two diseases. Finally, we propose several hypotheses of molecular mechanisms for AUD/PTSD and discuss potential future research directions that may provide new insights and translational application opportunities. |
format | Online Article Text |
id | pubmed-10218145 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102181452023-05-27 Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury Wang, Zufeng Luo, Chengliang Zhou, Edward W. Sandhu, Aaron F. Yuan, Xiaojing Williams, George E. Cheng, Jialu Sinha, Bharati Akbar, Mohammed Bhattacharya, Pallab Zhou, Shuanhu Song, Byoung-Joon Wang, Xin Int J Mol Sci Review The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well understood and the identification of the comorbidity state markers is significantly challenging. This review summarizes the main characteristics of comorbidity between AUD and PTSD (AUD/PTSD) and highlights the significance of a comprehensive understanding of the molecular toxicology and pathophysiological mechanisms of AUD/PTSD, particularly following TBI, with a focus on the role of metabolomics, inflammation, neuroendocrine, signal transduction pathways, and genetic regulation. Instead of a separate disease state, a comprehensive examination of comorbid AUD and PTSD is emphasized by considering additive and synergistic interactions between the two diseases. Finally, we propose several hypotheses of molecular mechanisms for AUD/PTSD and discuss potential future research directions that may provide new insights and translational application opportunities. MDPI 2023-05-15 /pmc/articles/PMC10218145/ /pubmed/37240148 http://dx.doi.org/10.3390/ijms24108805 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Wang, Zufeng Luo, Chengliang Zhou, Edward W. Sandhu, Aaron F. Yuan, Xiaojing Williams, George E. Cheng, Jialu Sinha, Bharati Akbar, Mohammed Bhattacharya, Pallab Zhou, Shuanhu Song, Byoung-Joon Wang, Xin Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury |
title | Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury |
title_full | Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury |
title_fullStr | Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury |
title_full_unstemmed | Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury |
title_short | Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury |
title_sort | molecular toxicology and pathophysiology of comorbid alcohol use disorder and post-traumatic stress disorder associated with traumatic brain injury |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218145/ https://www.ncbi.nlm.nih.gov/pubmed/37240148 http://dx.doi.org/10.3390/ijms24108805 |
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