Cargando…

Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury

The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zufeng, Luo, Chengliang, Zhou, Edward W., Sandhu, Aaron F., Yuan, Xiaojing, Williams, George E., Cheng, Jialu, Sinha, Bharati, Akbar, Mohammed, Bhattacharya, Pallab, Zhou, Shuanhu, Song, Byoung-Joon, Wang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218145/
https://www.ncbi.nlm.nih.gov/pubmed/37240148
http://dx.doi.org/10.3390/ijms24108805
_version_ 1785048704114229248
author Wang, Zufeng
Luo, Chengliang
Zhou, Edward W.
Sandhu, Aaron F.
Yuan, Xiaojing
Williams, George E.
Cheng, Jialu
Sinha, Bharati
Akbar, Mohammed
Bhattacharya, Pallab
Zhou, Shuanhu
Song, Byoung-Joon
Wang, Xin
author_facet Wang, Zufeng
Luo, Chengliang
Zhou, Edward W.
Sandhu, Aaron F.
Yuan, Xiaojing
Williams, George E.
Cheng, Jialu
Sinha, Bharati
Akbar, Mohammed
Bhattacharya, Pallab
Zhou, Shuanhu
Song, Byoung-Joon
Wang, Xin
author_sort Wang, Zufeng
collection PubMed
description The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well understood and the identification of the comorbidity state markers is significantly challenging. This review summarizes the main characteristics of comorbidity between AUD and PTSD (AUD/PTSD) and highlights the significance of a comprehensive understanding of the molecular toxicology and pathophysiological mechanisms of AUD/PTSD, particularly following TBI, with a focus on the role of metabolomics, inflammation, neuroendocrine, signal transduction pathways, and genetic regulation. Instead of a separate disease state, a comprehensive examination of comorbid AUD and PTSD is emphasized by considering additive and synergistic interactions between the two diseases. Finally, we propose several hypotheses of molecular mechanisms for AUD/PTSD and discuss potential future research directions that may provide new insights and translational application opportunities.
format Online
Article
Text
id pubmed-10218145
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102181452023-05-27 Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury Wang, Zufeng Luo, Chengliang Zhou, Edward W. Sandhu, Aaron F. Yuan, Xiaojing Williams, George E. Cheng, Jialu Sinha, Bharati Akbar, Mohammed Bhattacharya, Pallab Zhou, Shuanhu Song, Byoung-Joon Wang, Xin Int J Mol Sci Review The increasing comorbidity of alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD) associated with traumatic brain injury (TBI) is a serious medical, economic, and social issue. However, the molecular toxicology and pathophysiological mechanisms of comorbid AUD and PTSD are not well understood and the identification of the comorbidity state markers is significantly challenging. This review summarizes the main characteristics of comorbidity between AUD and PTSD (AUD/PTSD) and highlights the significance of a comprehensive understanding of the molecular toxicology and pathophysiological mechanisms of AUD/PTSD, particularly following TBI, with a focus on the role of metabolomics, inflammation, neuroendocrine, signal transduction pathways, and genetic regulation. Instead of a separate disease state, a comprehensive examination of comorbid AUD and PTSD is emphasized by considering additive and synergistic interactions between the two diseases. Finally, we propose several hypotheses of molecular mechanisms for AUD/PTSD and discuss potential future research directions that may provide new insights and translational application opportunities. MDPI 2023-05-15 /pmc/articles/PMC10218145/ /pubmed/37240148 http://dx.doi.org/10.3390/ijms24108805 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Zufeng
Luo, Chengliang
Zhou, Edward W.
Sandhu, Aaron F.
Yuan, Xiaojing
Williams, George E.
Cheng, Jialu
Sinha, Bharati
Akbar, Mohammed
Bhattacharya, Pallab
Zhou, Shuanhu
Song, Byoung-Joon
Wang, Xin
Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury
title Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury
title_full Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury
title_fullStr Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury
title_full_unstemmed Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury
title_short Molecular Toxicology and Pathophysiology of Comorbid Alcohol Use Disorder and Post-Traumatic Stress Disorder Associated with Traumatic Brain Injury
title_sort molecular toxicology and pathophysiology of comorbid alcohol use disorder and post-traumatic stress disorder associated with traumatic brain injury
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218145/
https://www.ncbi.nlm.nih.gov/pubmed/37240148
http://dx.doi.org/10.3390/ijms24108805
work_keys_str_mv AT wangzufeng moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT luochengliang moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT zhouedwardw moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT sandhuaaronf moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT yuanxiaojing moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT williamsgeorgee moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT chengjialu moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT sinhabharati moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT akbarmohammed moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT bhattacharyapallab moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT zhoushuanhu moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT songbyoungjoon moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury
AT wangxin moleculartoxicologyandpathophysiologyofcomorbidalcoholusedisorderandposttraumaticstressdisorderassociatedwithtraumaticbraininjury