Cargando…

Design, Synthesis and Antitumor Activity of 1H-indazole-3-amine Derivatives

A series of indazole derivatives were designed and synthesized by molecular hybridization strategy, and these compounds were evaluated the inhibitory activities against human cancer cell lines of lung (A549), chronic myeloid leukemia (K562), prostate (PC-3), and hepatoma (Hep-G2) by methyl thiazolyl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Congyu, Zhu, Mei, Long, Xuesha, Wang, Qin, Wang, Zhenchao, Ouyang, Guiping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218234/ https://www.ncbi.nlm.nih.gov/pubmed/37240028 http://dx.doi.org/10.3390/ijms24108686

Ejemplares similares

Discovery and Mechanism of Novel 7-Aliphatic Amine Tryptanthrin Derivatives against Phytopathogenic Bacteria
por: Long, Xuesha, et al.
Publicado: (2023)

Antibacterial Activity of Allicin-Inspired Disulfide Derivatives against Xanthomonas axonopodis pv. citri
por: Zhu, Mei, et al.
Publicado: (2022)

1,3-Dimethyl-1H-indazol-6-amine
por: Zhang, Xiao-Kai, et al.
Publicado: (2012)

Design, synthesis and in vitro biological evaluation of quinazolinone derivatives as EGFR inhibitors for antitumor treatment
por: Le, Yi, et al.
Publicado: (2020)

Design, Synthesis and Anticandidal Evaluation of Indazole and Pyrazole Derivatives
por: Rodríguez-Villar, Karen, et al.
Publicado: (2021)

Synthesis of 2-Alkenyl-2H-indazoles from 2-(2-Carbonylmethyl)-2H-indazoles
por: Lin, Mei-Huey, et al.
Publicado: (2016)

Synthesis of 1H-Indazoles via Silver(I)-Mediated Intramolecular Oxidative C–H Bond Amination
por: Park, Areum, et al.
Publicado: (2021)

Tris[2-(2H-indazol-2-yl)ethyl]amine
por: Ovalle, Saúl, et al.
Publicado: (2012)

Microwave-assisted synthesis of 7-azaindoles via iron-catalyzed cyclization of an o-haloaromatic amine with terminal alkynes
por: Le, Yi, et al.
Publicado: (2019)

Synthesis and biological assessment of indole derivatives containing penta-heterocycles scaffold as novel anticancer agents towards A549 and K562 cells
por: Zhang, Guanglong, et al.
Publicado: (2023)

N-[(E)-Quinoxalin-2-ylmethylidene]-1H-indazol-5-amine
por: Leeju, P., et al.
Publicado: (2009)

Synthesis, Antiprotozoal Activity, and Cheminformatic Analysis of 2-Phenyl-2H-Indazole Derivatives
por: Rodríguez-Villar, Karen, et al.
Publicado: (2021)

Design, Synthesis, and Antitumor Activity of Erlotinib Derivatives
por: Mao, Long-fei, et al.
Publicado: (2022)

Recent Advances in Indazole-Containing Derivatives: Synthesis and Biological Perspectives
por: Zhang, Shu-Guang, et al.
Publicado: (2018)

Synthesis and biological evaluation of indazole derivatives as anti-cancer agents
por: Wei, Wei, et al.
Publicado: (2021)

New Indazol-Pyrimidine-Based Derivatives as Selective Anticancer Agents: Design, Synthesis, and In Silico Studies
por: Al-Tuwaijri, Hanaa M., et al.
Publicado: (2023)

1-Methyl-1H-indazole-3-carboxylic acid
por: Kang, Si-shun, et al.
Publicado: (2008)

One-Pot Synthesis of Novel 2,3-Dihydro-1H-indazoles
por: Breton, Gary W., et al.
Publicado: (2011)

2-Methyl-6-nitro-2H-indazole
por: Long, Li, et al.
Publicado: (2011)

Synthesis and Biological Evaluation of 2H-Indazole Derivatives: Towards Antimicrobial and Anti-Inflammatory Dual Agents
por: Pérez-Villanueva, Jaime, et al.
Publicado: (2017)

N-(2-Chloropyrimidin-4-yl)-2-methyl-2H-indazol-6-amine methanol monosolvate
por: Pang, Xiang-Chuan, et al.
Publicado: (2011)

N-(2-Chloropyrimidin-4-yl)-N,2-dimethyl-2H-indazol-6-amine
por: Qi, Hao-Fei, et al.
Publicado: (2010)

Rh(iii)-catalyzed double C–H activation of aldehyde hydrazones: a route for functionalized 1H-indazole synthesis
por: Xu, Pan, et al.
Publicado: (2017)

Synthesis of indazoles from 2-formylphenylboronic acids
por: Solomin, Vitalii V., et al.
Publicado: (2021)

2-(4-Methylphenyl)-2H-indazole
por: Zhou, Xingqin, et al.
Publicado: (2010)

AMI, an Indazole Derivative, Improves Parkinson’s Disease by Inhibiting Tau Phosphorylation
por: Mao, Zhang, et al.
Publicado: (2020)

Design, Synthesis, and Antitumor Activity of Novel Quinazoline Derivatives
por: Wang, Liuchang, et al.
Publicado: (2017)

Rhodium(III)-Catalyzed Indazole Synthesis by C–H Bond Functionalization and Cyclative Capture
por: Lian, Yajing, et al.
Publicado: (2013)

2,3-Dimethyl-6-nitro-2H-indazole
por: Chen, Yan, et al.
Publicado: (2009)

An optimized procedure for direct access to 1H-indazole-3-carboxaldehyde derivatives by nitrosation of indoles
por: Chevalier, Arnaud, et al.
Publicado: (2018)

Design and Synthesis of New 6-Nitro and 6-Amino-3,3a,4,5-Tetrahydro-2H-Benzo[g]indazole Derivatives: Antiproliferative and Antibacterial Activity
por: Cuartas, Viviana, et al.
Publicado: (2019)

1-Allyl-6-nitro-1H-indazole
por: El Brahmi, Nabil, et al.
Publicado: (2012)

2-Allyl-7-nitro-2H-indazole
por: Kouakou, Assoman, et al.
Publicado: (2013)

Synthesis and Cytotoxic Activity of Combretastatin A-4 and 2,3-Diphenyl-2H-indazole Hybrids
por: Pérez-Villanueva, Jaime, et al.
Publicado: (2021)

Syntheses of 1-Aryl-5-nitro-1H-indazoles and a General One-Pot Route to 1-Aryl-1H-indazoles
por: Annor-Gyamfi, Joel K., et al.
Publicado: (2018)

Synthesis of Succinimide-Linked Indazol-3-ols Derived from Maleimides under Rh(III) Catalysis
por: Kang, Ju Young, et al.
Publicado: (2022)

Cyclophilin J PPIase Inhibitors Derived from 2,3-Quinoxaline-6 Amine Exhibit Antitumor Activity
por: Zhao, Xuemei, et al.
Publicado: (2018)

Design, synthesis and biological evaluation of novel 1H-1,2,4-triazole, benzothiazole and indazole-based derivatives as potent FGFR1 inhibitors viafragment-based virtual screening
por: Liu, Jian, et al.
Publicado: (2019)

Efficient MW-Assisted Synthesis, Spectroscopic Characterization, X-ray and Antioxidant Properties of Indazole Derivatives
por: Polo, Efrain, et al.
Publicado: (2016)

1-Allyl-3-chloro-6-nitro-1H-indazole
por: El Brahmi, Nabil, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_6ro8a53cf1ns712uhvpb2r8v97