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A Review on Cyclodextrins/Estrogens Inclusion Complexes

This review focuses on the methods of preparation and biological, physiochemical, and theoretical analysis of the inclusion complexes formed between estrogens and cyclodextrins (CDs). Because estrogens have a low polarity, they can interact with some cyclodextrins’ hydrophobic cavities to create inc...

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Detalles Bibliográficos
Autores principales: Araj, Szymon Kamil, Szeleszczuk, Łukasz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218237/
https://www.ncbi.nlm.nih.gov/pubmed/37240133
http://dx.doi.org/10.3390/ijms24108780
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author Araj, Szymon Kamil
Szeleszczuk, Łukasz
author_facet Araj, Szymon Kamil
Szeleszczuk, Łukasz
author_sort Araj, Szymon Kamil
collection PubMed
description This review focuses on the methods of preparation and biological, physiochemical, and theoretical analysis of the inclusion complexes formed between estrogens and cyclodextrins (CDs). Because estrogens have a low polarity, they can interact with some cyclodextrins’ hydrophobic cavities to create inclusion complexes, if their geometric properties are compatible. For the last forty years, estrogen-CD complexes have been widely applied in several fields for various objectives. For example, CDs have been used as estrogen solubilizers and absorption boosters in pharmaceutical formulations, as well as in chromatographic and electrophoretic procedures for their separation and quantification. Other applications include the removal of the endocrine disruptors from environmental materials, the preparation of the samples for mass spectrometric analysis, or solid-phase extractions based on complex formation with CDs. The aim of this review is to gather the most important outcomes from the works related to this topic, presenting the results of synthesis, in silico, in vitro, and in vivo analysis.
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spelling pubmed-102182372023-05-27 A Review on Cyclodextrins/Estrogens Inclusion Complexes Araj, Szymon Kamil Szeleszczuk, Łukasz Int J Mol Sci Review This review focuses on the methods of preparation and biological, physiochemical, and theoretical analysis of the inclusion complexes formed between estrogens and cyclodextrins (CDs). Because estrogens have a low polarity, they can interact with some cyclodextrins’ hydrophobic cavities to create inclusion complexes, if their geometric properties are compatible. For the last forty years, estrogen-CD complexes have been widely applied in several fields for various objectives. For example, CDs have been used as estrogen solubilizers and absorption boosters in pharmaceutical formulations, as well as in chromatographic and electrophoretic procedures for their separation and quantification. Other applications include the removal of the endocrine disruptors from environmental materials, the preparation of the samples for mass spectrometric analysis, or solid-phase extractions based on complex formation with CDs. The aim of this review is to gather the most important outcomes from the works related to this topic, presenting the results of synthesis, in silico, in vitro, and in vivo analysis. MDPI 2023-05-15 /pmc/articles/PMC10218237/ /pubmed/37240133 http://dx.doi.org/10.3390/ijms24108780 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Araj, Szymon Kamil
Szeleszczuk, Łukasz
A Review on Cyclodextrins/Estrogens Inclusion Complexes
title A Review on Cyclodextrins/Estrogens Inclusion Complexes
title_full A Review on Cyclodextrins/Estrogens Inclusion Complexes
title_fullStr A Review on Cyclodextrins/Estrogens Inclusion Complexes
title_full_unstemmed A Review on Cyclodextrins/Estrogens Inclusion Complexes
title_short A Review on Cyclodextrins/Estrogens Inclusion Complexes
title_sort review on cyclodextrins/estrogens inclusion complexes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218237/
https://www.ncbi.nlm.nih.gov/pubmed/37240133
http://dx.doi.org/10.3390/ijms24108780
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