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A Review on Cyclodextrins/Estrogens Inclusion Complexes
This review focuses on the methods of preparation and biological, physiochemical, and theoretical analysis of the inclusion complexes formed between estrogens and cyclodextrins (CDs). Because estrogens have a low polarity, they can interact with some cyclodextrins’ hydrophobic cavities to create inc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218237/ https://www.ncbi.nlm.nih.gov/pubmed/37240133 http://dx.doi.org/10.3390/ijms24108780 |
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author | Araj, Szymon Kamil Szeleszczuk, Łukasz |
author_facet | Araj, Szymon Kamil Szeleszczuk, Łukasz |
author_sort | Araj, Szymon Kamil |
collection | PubMed |
description | This review focuses on the methods of preparation and biological, physiochemical, and theoretical analysis of the inclusion complexes formed between estrogens and cyclodextrins (CDs). Because estrogens have a low polarity, they can interact with some cyclodextrins’ hydrophobic cavities to create inclusion complexes, if their geometric properties are compatible. For the last forty years, estrogen-CD complexes have been widely applied in several fields for various objectives. For example, CDs have been used as estrogen solubilizers and absorption boosters in pharmaceutical formulations, as well as in chromatographic and electrophoretic procedures for their separation and quantification. Other applications include the removal of the endocrine disruptors from environmental materials, the preparation of the samples for mass spectrometric analysis, or solid-phase extractions based on complex formation with CDs. The aim of this review is to gather the most important outcomes from the works related to this topic, presenting the results of synthesis, in silico, in vitro, and in vivo analysis. |
format | Online Article Text |
id | pubmed-10218237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102182372023-05-27 A Review on Cyclodextrins/Estrogens Inclusion Complexes Araj, Szymon Kamil Szeleszczuk, Łukasz Int J Mol Sci Review This review focuses on the methods of preparation and biological, physiochemical, and theoretical analysis of the inclusion complexes formed between estrogens and cyclodextrins (CDs). Because estrogens have a low polarity, they can interact with some cyclodextrins’ hydrophobic cavities to create inclusion complexes, if their geometric properties are compatible. For the last forty years, estrogen-CD complexes have been widely applied in several fields for various objectives. For example, CDs have been used as estrogen solubilizers and absorption boosters in pharmaceutical formulations, as well as in chromatographic and electrophoretic procedures for their separation and quantification. Other applications include the removal of the endocrine disruptors from environmental materials, the preparation of the samples for mass spectrometric analysis, or solid-phase extractions based on complex formation with CDs. The aim of this review is to gather the most important outcomes from the works related to this topic, presenting the results of synthesis, in silico, in vitro, and in vivo analysis. MDPI 2023-05-15 /pmc/articles/PMC10218237/ /pubmed/37240133 http://dx.doi.org/10.3390/ijms24108780 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Araj, Szymon Kamil Szeleszczuk, Łukasz A Review on Cyclodextrins/Estrogens Inclusion Complexes |
title | A Review on Cyclodextrins/Estrogens Inclusion Complexes |
title_full | A Review on Cyclodextrins/Estrogens Inclusion Complexes |
title_fullStr | A Review on Cyclodextrins/Estrogens Inclusion Complexes |
title_full_unstemmed | A Review on Cyclodextrins/Estrogens Inclusion Complexes |
title_short | A Review on Cyclodextrins/Estrogens Inclusion Complexes |
title_sort | review on cyclodextrins/estrogens inclusion complexes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218237/ https://www.ncbi.nlm.nih.gov/pubmed/37240133 http://dx.doi.org/10.3390/ijms24108780 |
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