Cargando…

RNA-Seq Analysis Reveals an Essential Role of the cGMP-PKG-MAPK Pathways in Retinal Degeneration Caused by Cep250 Deficiency

Usher syndrome (USH) is characterised by degenerative vision loss known as retinitis pigmentosa (RP), sensorineural hearing loss, and vestibular dysfunction. RP can cause degeneration and the loss of rod and cone photoreceptors, leading to structural and functional changes in the retina. Cep250 is a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Chong, Rong, Yu, Zhuang, Youyuan, Tang, Cheng, Liu, Qian, Lin, Peng, Li, Dandan, Zhao, Xinyi, Lu, Fan, Qu, Jia, Liu, Xinting
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218315/ https://www.ncbi.nlm.nih.gov/pubmed/37240188 http://dx.doi.org/10.3390/ijms24108843

Ejemplares similares

The role of cGMP and PKG in cardioprotection
por: Downey, James M, et al.
Publicado: (2009)

Role of cGMP/PKG in fat tissue
por: Pfeifer, Alexander
Publicado: (2011)

Structures of human PKG reveal cGMP-selectived activation mechanisms
por: Huang, Gilbert Y, et al.
Publicado: (2013)

cGMP at the centre of attention: emerging strategies for activating the cardioprotective PKG pathway
por: Park, Min, et al.
Publicado: (2018)

Dysregulated Arginine Metabolism Is Linked to Retinal Degeneration in Cep250 Knockout Mice
por: Xiang, Lue, et al.
Publicado: (2023)

Kinase activity profiling identifies putative downstream targets of cGMP/PKG signaling in inherited retinal neurodegeneration
por: Roy, Akanksha, et al.
Publicado: (2022)

Nucleotide de novo synthesis increases breast cancer stemness and metastasis via cGMP-PKG-MAPK signaling pathway
por: Lv, Yajing, et al.
Publicado: (2020)

Construction of novel cGMP FRET-sensors based on PKG from Plasmodium falciparum
por: Calamera, Gaia, et al.
Publicado: (2015)

The NO-cGMP-PKG Axis in HFpEF: From Pathological Mechanisms to Potential Therapies
por: Cai, Zhulan, et al.
Publicado: (2023)

The Role of NO/sGC/cGMP/PKG Signaling Pathway in Regulation of Platelet Function
por: Gambaryan, Stepan
Publicado: (2022)

Identification of Novel Substrates for cGMP Dependent Protein Kinase (PKG) through Kinase Activity Profiling to Understand Its Putative Role in Inherited Retinal Degeneration
por: Roy, Akanksha, et al.
Publicado: (2021)

PKC and AKT Modulate cGMP/PKG Signaling Pathway on Platelet Aggregation in Experimental Sepsis
por: Lopes-Pires, M. Elisa, et al.
Publicado: (2015)

The NO/cGMP/PKG pathway in platelets: The therapeutic potential of PDE5 inhibitors in platelet disorders
por: Degjoni, Anisa, et al.
Publicado: (2022)

cGMP Signaling in Photoreceptor Degeneration
por: Li, Shujuan, et al.
Publicado: (2023)

Src activation by cGMP/PKG II in osteoblasts: characterization of a mechano-sensitive signalling complex
por: Rangaswami, Hema, et al.
Publicado: (2011)

Protoporphyrin IX Stimulates Melanogenesis, Melanocyte Dendricity, and Melanosome Transport Through the cGMP/PKG Pathway
por: Lv, Jinpeng, et al.
Publicado: (2020)

Cardiac natriuretic peptides inhibit TRPC6-mediated prohypertrophic signaling through cGMP-PKG pathway
por: Kinoshita, Hideyuki, et al.
Publicado: (2009)

Is enhancing cGMP-PKG signalling a promising therapeutic target for heart failure with preserved ejection fraction?
por: Kovács, Á., et al.
Publicado: (2016)

Nitric Oxide Enhances Keratinocyte Cell Migration by Regulating Rho GTPase via cGMP-PKG Signalling
por: Zhan, Rixing, et al.
Publicado: (2015)

Burn-Induced Cardiac Mitochondrial Dysfunction via Interruption of the PDE5A-cGMP-PKG Pathway
por: Wen, Jake J., et al.
Publicado: (2020)

Heart Failure With Preserved Ejection Fraction and Obesity: Syndrome of cGMP-PKG Deficiency in Post-Menopausal Women
por: Sinha, Arjun, et al.
Publicado: (2020)

Swimming exercise inhibits myocardial ER stress in the hearts of aged mice by enhancing cGMP-PKG signaling
por: Chang, Pan, et al.
Publicado: (2020)

Role of G-Substrate in the NO/cGMP/PKG Signal Transduction Pathway for Photic Entrainment of the Hamster Circadian Clock
por: Plano, Santiago Andrés, et al.
Publicado: (2021)

Myocardial stretch-induced compliance is abrogated under ischemic conditions and restored by cGMP/PKG-related pathways
por: Leite-Moreira, André M., et al.
Publicado: (2023)

Elevated retinal cGMP is not associated with elevated circulating cGMP levels in a canine model of retinitis pigmentosa
por: Occelli, Laurence M., et al.
Publicado: (2022)

The NO-cGMP-PKG signal transduction pathway is involved in the analgesic effect of early hyperbaric oxygen treatment of neuropathic pain
por: Ding, Yuanyuan, et al.
Publicado: (2017)

cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases
por: VerPlank, Jordan J. S., et al.
Publicado: (2020)

Mechanistic insights on novel small molecule allosteric activators of cGMP-dependent protein kinase PKG1α
por: Tawa, Paul, et al.
Publicado: (2022)

Nitric Oxide Mobilizes Intracellular Zn(2+) via the GC/cGMP/PKG Signaling Pathway and Stimulates Adipocyte Differentiation
por: Chen, Chien-Wei, et al.
Publicado: (2022)

NO-cGMP signalling and cancer therapy
por: Bian, Ka, et al.
Publicado: (2013)

VDR Regulates BNP Promoting Neurite Growth and Survival of Cochlear Spiral Ganglion Neurons through cGMP-PKG Signaling Pathway
por: Zhang, Xinyu, et al.
Publicado: (2022)

Homozygous Knockout of Cep250 Leads to a Relatively Late-Onset Retinal Degeneration and Sensorineural Hearing Loss in Mice
por: Abu-Diab, Alaa, et al.
Publicado: (2023)

Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)
por: Lee, Jia Hai, et al.
Publicado: (2007)

cGMP-PKG upregulates PGC1α and improves cardiac function in advanced cardiac hypertrophy independently of RGS2
por: Takimoto, Eiki
Publicado: (2011)

Magnesium Lithospermate B, an Active Extract of Salvia miltiorrhiza, Mediates sGC/cGMP/PKG Translocation in Experimental Vasospasm
por: Chang, Chih-Zen, et al.
Publicado: (2014)

The new nitric oxide donor cyclohexane nitrate induces vasorelaxation, hypotension, and antihypertensive effects via NO/cGMP/PKG pathway
por: Mendes-Júnior, Leônidas das G., et al.
Publicado: (2015)

Sini-San Regulates the NO-cGMP-PKG Pathway in the Spinal Dorsal Horn in a Modified Rat Model of Functional Dyspepsia
por: Wu, Zhenyu, et al.
Publicado: (2020)

Prenatal Stress Impairs Postnatal Learning and Memory Development via Disturbance of the cGMP–PKG Pathway and Oxidative Phosphorylation in the Hippocampus of Rats
por: Li, Yu-jie, et al.
Publicado: (2020)

Cyclic GMP and PKG Signaling in Heart Failure
por: Numata, Genri, et al.
Publicado: (2022)

The cGMP system in normal and degenerating mouse neuroretina: New proteins with cGMP interaction potential identified by a proteomics approach
por: Rasmussen, Michel, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_iheklm86a5unmjrrnm8hfv0cid