JAC4 Inhibits EGFR-Driven Lung Adenocarcinoma Growth and Metastasis through CTBP1-Mediated JWA/AMPK/NEDD4L/EGFR Axis

Lung adenocarcinoma (LUAD) is the most common lung cancer, with high mortality. As a tumor-suppressor gene, JWA plays an important role in blocking pan-tumor progression. JAC4, a small molecular-compound agonist, transcriptionally activates JWA expression both in vivo and in vitro. However, the dire...

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Detalles Bibliográficos
Autores principales: Ding, Kun, Jiang, Xuqian, Wang, Zhangding, Zou, Lu, Cui, Jiahua, Li, Xiong, Shu, Chuanjun, Li, Aiping, Zhou, Jianwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218353/
https://www.ncbi.nlm.nih.gov/pubmed/37240137
http://dx.doi.org/10.3390/ijms24108794

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