Cargando…

No Substrate Left behind—Mining of Shotgun Proteomics Datasets Rescues Evidence of Proteolysis by SARS-CoV-2 3CL(pro) Main Protease

Proteolytic processing is the most ubiquitous post-translational modification and regulator of protein function. To identify protease substrates, and hence the function of proteases, terminomics workflows have been developed to enrich and detect proteolytically generated protein termini from mass sp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bell, Peter A., Overall, Christopher M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218362/ https://www.ncbi.nlm.nih.gov/pubmed/37240067 http://dx.doi.org/10.3390/ijms24108723

Ejemplares similares

Experimental setup for the identification of mitochondrial protease substrates by shotgun and top-down proteomics
por: Di Pierro, Alice, et al.
Publicado: (2016)

QM/QM studies for Michael reaction in coronavirus main protease (3CL(Pro))
por: Taranto, Alex G., et al.
Publicado: (2008)

Inhibition of the SARS-CoV-2 3CL(pro) main protease by plant polyphenols
por: Bahun, Miha, et al.
Publicado: (2022)

Development of Broad‐Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CL(pro)
por: Bacha, Usman, et al.
Publicado: (2008)

In silico analysis of echinocandins binding to the main proteases of coronaviruses PEDV (3CL(pro)) and SARS-CoV-2 (M(pro))
por: Vergoten, Gérard, et al.
Publicado: (2021)

In Silico Substrate-Binding Profiling for SARS-CoV-2 Main Protease (M(pro)) Using Hexapeptide Substrates
por: Zabo, Sophakama, et al.
Publicado: (2023)

Quantitative proteomics and terminomics to elucidate the role of ubiquitination and proteolysis in adaptive immunity
por: Klein, Theo, et al.
Publicado: (2016)

Shotgun Proteomics Revealed Preferential Degradation of Misfolded In Vivo Obligate GroE Substrates by Lon Protease in Escherichia coli
por: Niwa, Tatsuya, et al.
Publicado: (2022)

The Power of Three in Cannabis Shotgun Proteomics: Proteases, Databases and Search Engines
por: Vincent, Delphine, et al.
Publicado: (2020)

Identification of fungi in shotgun metagenomics datasets
por: Donovan, Paul D., et al.
Publicado: (2018)

Identification of potential binders of the main protease 3CL(pro) of the COVID-19 via structure-based ligand design and molecular modeling
por: Macchiagodena, Marina, et al.
Publicado: (2020)

Insilico generation of novel ligands for the inhibition of SARS-CoV-2 main protease (3CL(pro)) using deep learning
por: Prabhakaran, Prejwal, et al.
Publicado: (2023)

The Degradome database: mammalian proteases and diseases of proteolysis
por: Quesada, Víctor, et al.
Publicado: (2009)

Solution structure of a soluble fragment derived from a membrane protein by shotgun proteolysis
por: Allen, Mark D., et al.
Publicado: (2015)

In Silico Mining of Terpenes from Red-Sea Invertebrates for SARS-CoV-2 Main Protease (M(pro)) Inhibitors
por: Ibrahim, Mahmoud A. A., et al.
Publicado: (2021)

Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL(pro) substrate degradome
por: Pablos, Isabel, et al.
Publicado: (2021)

Profiling of Substrate Specificity of SARS-CoV 3CL(pro)
por: Chuck, Chi-Pang, et al.
Publicado: (2010)

Recognizing millions of consistently unidentified spectra across hundreds of shotgun proteomics datasets
por: Griss, Johannes, et al.
Publicado: (2016)

Shotgun proteomics datasets acquired on Gammarus pulex animals sampled from the wild
por: Gouveia, Duarte, et al.
Publicado: (2019)

Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant
por: Akaji, Kenichi, et al.
Publicado: (2008)

Ensemble Docking Coupled to Linear Interaction Energy Calculations for Identification of Coronavirus Main Protease (3CL(pro)) Non-Covalent Small-Molecule Inhibitors
por: Jukič, Marko, et al.
Publicado: (2020)

A Multiple Protease Strategy to Optimise the Shotgun Proteomics of Mature Medicinal Cannabis Buds
por: Vincent, Delphine, et al.
Publicado: (2019)

Characterization of host substrates of SARS-CoV-2 main protease
por: Melano, Ivonne, et al.
Publicado: (2023)

Derivation of HLA types from shotgun sequence datasets
por: Warren, René L, et al.
Publicado: (2012)

Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat's Claw) against the Main Protease 3CL(pro) of SARS-CoV-2 by Molecular Modeling
por: Yepes-Pérez, Andres F., et al.
Publicado: (2020)

Inhibition of SARS-CoV-2 main protease 3CL(pro) by means of α-ketoamide and pyridone-containing pharmaceuticals using in silico molecular docking
por: Elzupir, Amin O.
Publicado: (2020)

Detection of Plasma Protease Activity Using Microsphere-Cytometry Assays with E. coli Derived Substrates: VWF Proteolysis by ADAMTS13
por: Gogia, Shobhit, et al.
Publicado: (2015)

A plasma proteolysis pathway comprising blood coagulation proteases
por: Yang, Lu, et al.
Publicado: (2016)

Peptide aldehyde inhibitors challenge the substrate specificity of the SARS-coronavirus main protease
por: Zhu, Lili, et al.
Publicado: (2011)

Characterization of SARS main protease and inhibitor assay using a fluorogenic substrate()
por: Kuo, Chih-Jung, et al.
Publicado: (2004)

Identification of Host Cellular Protein Substrates of SARS-COV-2 Main Protease
por: Miczi, Márió, et al.
Publicado: (2020)

SARS-CoV-2 main protease (3CL(pro)) interaction with acyclovir antiviral drug/methyl-β-cyclodextrin complex: Physiochemical characterization and molecular docking
por: Mohandoss, Sonaimuthu, et al.
Publicado: (2022)

Amentoflavone derivatives significantly act towards the main protease (3CL(PRO)/M(PRO)) of SARS-CoV-2: in silico admet profiling, molecular docking, molecular dynamics simulation, network pharmacology
por: Dey, Dipta, et al.
Publicado: (2022)

Virtual high throughput screening: Potential inhibitors for SARS-CoV-2 PL(PRO) and 3CL(PRO) proteases
por: Jade, Dhananjay, et al.
Publicado: (2021)

Diphenyl Diselenide and SARS-CoV-2: in silico Exploration of the Mechanisms of Inhibition of Main Protease (M(pro)) and Papain-like Protease (PL(pro))
por: Omage, Folorunsho Bright, et al.
Publicado: (2023)

Effects on the Qualities of Proteolysis to Beef by Non-coating and Coating Protease Treatment
por: Kim, Kwang-Il, et al.
Publicado: (2016)

Engineered AAA+ proteases reveal principles of proteolysis at the mitochondrial inner membrane
por: Shi, Hui, et al.
Publicado: (2016)

Substrate–Enzyme Interactions in Intramembrane Proteolysis: γ-Secretase as the Prototype
por: Liu, Xinyue, et al.
Publicado: (2020)

Mutation of Glu-166 Blocks the Substrate-Induced Dimerization of SARS Coronavirus Main Protease
por: Cheng, Shu-Chun, et al.
Publicado: (2010)

Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors
por: Ullrich, Sven, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3f7r3452ejb37m51bi4ns1f9c9