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The Genomic Landscape of Melanoma and Its Therapeutic Implications

Melanoma is one of the most aggressive malignancies of the skin. The genetic composition of melanoma is complex and varies among different subtypes. With the aid of recent technologies such as next generation sequencing and single-cell sequencing, our understanding of the genomic landscape of melano...

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Autores principales: Yang, Ting-Ting, Yu, Sebastian, Ke, Chiao-Li Khale, Cheng, Shih-Tsung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218388/
https://www.ncbi.nlm.nih.gov/pubmed/37239381
http://dx.doi.org/10.3390/genes14051021
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author Yang, Ting-Ting
Yu, Sebastian
Ke, Chiao-Li Khale
Cheng, Shih-Tsung
author_facet Yang, Ting-Ting
Yu, Sebastian
Ke, Chiao-Li Khale
Cheng, Shih-Tsung
author_sort Yang, Ting-Ting
collection PubMed
description Melanoma is one of the most aggressive malignancies of the skin. The genetic composition of melanoma is complex and varies among different subtypes. With the aid of recent technologies such as next generation sequencing and single-cell sequencing, our understanding of the genomic landscape of melanoma and its tumor microenvironment has become increasingly clear. These advances may provide explanation to the heterogenic treatment outcomes of melanoma patients under current therapeutic guidelines and provide further insights to the development of potential new therapeutic targets. Here, we provide a comprehensive review on the genetics related to melanoma tumorigenesis, metastasis, and prognosis. We also review the genetics affecting the melanoma tumor microenvironment and its relation to tumor progression and treatment.
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spelling pubmed-102183882023-05-27 The Genomic Landscape of Melanoma and Its Therapeutic Implications Yang, Ting-Ting Yu, Sebastian Ke, Chiao-Li Khale Cheng, Shih-Tsung Genes (Basel) Review Melanoma is one of the most aggressive malignancies of the skin. The genetic composition of melanoma is complex and varies among different subtypes. With the aid of recent technologies such as next generation sequencing and single-cell sequencing, our understanding of the genomic landscape of melanoma and its tumor microenvironment has become increasingly clear. These advances may provide explanation to the heterogenic treatment outcomes of melanoma patients under current therapeutic guidelines and provide further insights to the development of potential new therapeutic targets. Here, we provide a comprehensive review on the genetics related to melanoma tumorigenesis, metastasis, and prognosis. We also review the genetics affecting the melanoma tumor microenvironment and its relation to tumor progression and treatment. MDPI 2023-04-29 /pmc/articles/PMC10218388/ /pubmed/37239381 http://dx.doi.org/10.3390/genes14051021 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Ting-Ting
Yu, Sebastian
Ke, Chiao-Li Khale
Cheng, Shih-Tsung
The Genomic Landscape of Melanoma and Its Therapeutic Implications
title The Genomic Landscape of Melanoma and Its Therapeutic Implications
title_full The Genomic Landscape of Melanoma and Its Therapeutic Implications
title_fullStr The Genomic Landscape of Melanoma and Its Therapeutic Implications
title_full_unstemmed The Genomic Landscape of Melanoma and Its Therapeutic Implications
title_short The Genomic Landscape of Melanoma and Its Therapeutic Implications
title_sort genomic landscape of melanoma and its therapeutic implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218388/
https://www.ncbi.nlm.nih.gov/pubmed/37239381
http://dx.doi.org/10.3390/genes14051021
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