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The Genomic Landscape of Melanoma and Its Therapeutic Implications
Melanoma is one of the most aggressive malignancies of the skin. The genetic composition of melanoma is complex and varies among different subtypes. With the aid of recent technologies such as next generation sequencing and single-cell sequencing, our understanding of the genomic landscape of melano...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218388/ https://www.ncbi.nlm.nih.gov/pubmed/37239381 http://dx.doi.org/10.3390/genes14051021 |
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author | Yang, Ting-Ting Yu, Sebastian Ke, Chiao-Li Khale Cheng, Shih-Tsung |
author_facet | Yang, Ting-Ting Yu, Sebastian Ke, Chiao-Li Khale Cheng, Shih-Tsung |
author_sort | Yang, Ting-Ting |
collection | PubMed |
description | Melanoma is one of the most aggressive malignancies of the skin. The genetic composition of melanoma is complex and varies among different subtypes. With the aid of recent technologies such as next generation sequencing and single-cell sequencing, our understanding of the genomic landscape of melanoma and its tumor microenvironment has become increasingly clear. These advances may provide explanation to the heterogenic treatment outcomes of melanoma patients under current therapeutic guidelines and provide further insights to the development of potential new therapeutic targets. Here, we provide a comprehensive review on the genetics related to melanoma tumorigenesis, metastasis, and prognosis. We also review the genetics affecting the melanoma tumor microenvironment and its relation to tumor progression and treatment. |
format | Online Article Text |
id | pubmed-10218388 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102183882023-05-27 The Genomic Landscape of Melanoma and Its Therapeutic Implications Yang, Ting-Ting Yu, Sebastian Ke, Chiao-Li Khale Cheng, Shih-Tsung Genes (Basel) Review Melanoma is one of the most aggressive malignancies of the skin. The genetic composition of melanoma is complex and varies among different subtypes. With the aid of recent technologies such as next generation sequencing and single-cell sequencing, our understanding of the genomic landscape of melanoma and its tumor microenvironment has become increasingly clear. These advances may provide explanation to the heterogenic treatment outcomes of melanoma patients under current therapeutic guidelines and provide further insights to the development of potential new therapeutic targets. Here, we provide a comprehensive review on the genetics related to melanoma tumorigenesis, metastasis, and prognosis. We also review the genetics affecting the melanoma tumor microenvironment and its relation to tumor progression and treatment. MDPI 2023-04-29 /pmc/articles/PMC10218388/ /pubmed/37239381 http://dx.doi.org/10.3390/genes14051021 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yang, Ting-Ting Yu, Sebastian Ke, Chiao-Li Khale Cheng, Shih-Tsung The Genomic Landscape of Melanoma and Its Therapeutic Implications |
title | The Genomic Landscape of Melanoma and Its Therapeutic Implications |
title_full | The Genomic Landscape of Melanoma and Its Therapeutic Implications |
title_fullStr | The Genomic Landscape of Melanoma and Its Therapeutic Implications |
title_full_unstemmed | The Genomic Landscape of Melanoma and Its Therapeutic Implications |
title_short | The Genomic Landscape of Melanoma and Its Therapeutic Implications |
title_sort | genomic landscape of melanoma and its therapeutic implications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218388/ https://www.ncbi.nlm.nih.gov/pubmed/37239381 http://dx.doi.org/10.3390/genes14051021 |
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