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Age-Dependent Causes of Death among Patients with Breast Cancer Based on Osaka Cancer Registry and Vital Statistics in Japan

We aimed to clarify the differences in causes of death among patients with breast cancer according to age at diagnosis and years elapsed since diagnosis. Using data from the Osaka Cancer Registry and Vital Statistics databases, 40,690 female patients diagnosed with primary breast cancer between 1985...

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Autores principales: Nagayasu, Mayumi, Morishima, Toshitaka, Fujii, Makoto, Kudo, Haruka, Sobue, Tomotaka, Ohno, Yuko, Miyashiro, Isao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218474/
https://www.ncbi.nlm.nih.gov/pubmed/37239701
http://dx.doi.org/10.3390/healthcare11101409
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author Nagayasu, Mayumi
Morishima, Toshitaka
Fujii, Makoto
Kudo, Haruka
Sobue, Tomotaka
Ohno, Yuko
Miyashiro, Isao
author_facet Nagayasu, Mayumi
Morishima, Toshitaka
Fujii, Makoto
Kudo, Haruka
Sobue, Tomotaka
Ohno, Yuko
Miyashiro, Isao
author_sort Nagayasu, Mayumi
collection PubMed
description We aimed to clarify the differences in causes of death among patients with breast cancer according to age at diagnosis and years elapsed since diagnosis. Using data from the Osaka Cancer Registry and Vital Statistics databases, 40,690 female patients diagnosed with primary breast cancer between 1985 and 2006 were included in this study. The statistics on all deaths between 1985 to 2016 were collected, and the observation period was 10 years (2006–2016). Mortality hazards according to age at diagnosis and years elapsed since diagnosis were estimated using a flexible parametric estimation. Of the 40,690 patients, 13,676 (34%) died from all-cause death, and the 10-year survival rate was 65.74% (95% confidence interval: 65.28–66.21). The proportions of deaths were 10,531 (77%) from breast cancer, 1048 (8%) from other cancers, and 2097 (15%) from non-cancer causes. The mortality hazard for deaths from breast cancer was initially high and then declined, whereas that for deaths from other cancers and non-cancer causes was initially low and then increased. The more likely causes of death 5 years after breast cancer diagnosis were other cancers or non-cancer causes among patients aged ≥70 years.
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spelling pubmed-102184742023-05-27 Age-Dependent Causes of Death among Patients with Breast Cancer Based on Osaka Cancer Registry and Vital Statistics in Japan Nagayasu, Mayumi Morishima, Toshitaka Fujii, Makoto Kudo, Haruka Sobue, Tomotaka Ohno, Yuko Miyashiro, Isao Healthcare (Basel) Article We aimed to clarify the differences in causes of death among patients with breast cancer according to age at diagnosis and years elapsed since diagnosis. Using data from the Osaka Cancer Registry and Vital Statistics databases, 40,690 female patients diagnosed with primary breast cancer between 1985 and 2006 were included in this study. The statistics on all deaths between 1985 to 2016 were collected, and the observation period was 10 years (2006–2016). Mortality hazards according to age at diagnosis and years elapsed since diagnosis were estimated using a flexible parametric estimation. Of the 40,690 patients, 13,676 (34%) died from all-cause death, and the 10-year survival rate was 65.74% (95% confidence interval: 65.28–66.21). The proportions of deaths were 10,531 (77%) from breast cancer, 1048 (8%) from other cancers, and 2097 (15%) from non-cancer causes. The mortality hazard for deaths from breast cancer was initially high and then declined, whereas that for deaths from other cancers and non-cancer causes was initially low and then increased. The more likely causes of death 5 years after breast cancer diagnosis were other cancers or non-cancer causes among patients aged ≥70 years. MDPI 2023-05-12 /pmc/articles/PMC10218474/ /pubmed/37239701 http://dx.doi.org/10.3390/healthcare11101409 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nagayasu, Mayumi
Morishima, Toshitaka
Fujii, Makoto
Kudo, Haruka
Sobue, Tomotaka
Ohno, Yuko
Miyashiro, Isao
Age-Dependent Causes of Death among Patients with Breast Cancer Based on Osaka Cancer Registry and Vital Statistics in Japan
title Age-Dependent Causes of Death among Patients with Breast Cancer Based on Osaka Cancer Registry and Vital Statistics in Japan
title_full Age-Dependent Causes of Death among Patients with Breast Cancer Based on Osaka Cancer Registry and Vital Statistics in Japan
title_fullStr Age-Dependent Causes of Death among Patients with Breast Cancer Based on Osaka Cancer Registry and Vital Statistics in Japan
title_full_unstemmed Age-Dependent Causes of Death among Patients with Breast Cancer Based on Osaka Cancer Registry and Vital Statistics in Japan
title_short Age-Dependent Causes of Death among Patients with Breast Cancer Based on Osaka Cancer Registry and Vital Statistics in Japan
title_sort age-dependent causes of death among patients with breast cancer based on osaka cancer registry and vital statistics in japan
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218474/
https://www.ncbi.nlm.nih.gov/pubmed/37239701
http://dx.doi.org/10.3390/healthcare11101409
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