Discovery of Chalcone-Based Hybrid Structures as High Affinity and Site-Specific Inhibitors against SARS-CoV-2: A Comprehensive Structural Analysis Based on Various Host-Based and Viral Targets

Previous studies indicated that natural-based chalcones have significant inhibitory effects on the coronavirus enzymes 3CLpro and PLpro as well as modulation of some host-based antiviral targets (HBATs). In this study, a comprehensive computational and structural study was performed to investigate t...

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Detalles Bibliográficos
Autores principales: Valipour, Mehdi, Di Giacomo, Silvia, Di Sotto, Antonella, Irannejad, Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218655/
https://www.ncbi.nlm.nih.gov/pubmed/37240149
http://dx.doi.org/10.3390/ijms24108789

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218655/
https://www.ncbi.nlm.nih.gov/pubmed/37240149
http://dx.doi.org/10.3390/ijms24108789

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