Cargando…

Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial

(1) Background: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for approximately 50% of all patients with HF. In the absence of pharmacological treatments that have been successful in reducing mortality or morbidity in this pathology, physical exercise is recognized as an impor...

Descripción completa

Detalles Bibliográficos
Autores principales: Cavero-Redondo, Iván, Saz-Lara, Alicia, Martínez-García, Irene, Bizzozero-Peroni, Bruno, Díaz-Goñi, Valentina, Díez-Fernández, Ana, Moreno-Herráiz, Nerea, Pascual-Morena, Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218785/
https://www.ncbi.nlm.nih.gov/pubmed/37240641
http://dx.doi.org/10.3390/jcm12103535
_version_ 1785048856274141184
author Cavero-Redondo, Iván
Saz-Lara, Alicia
Martínez-García, Irene
Bizzozero-Peroni, Bruno
Díaz-Goñi, Valentina
Díez-Fernández, Ana
Moreno-Herráiz, Nerea
Pascual-Morena, Carlos
author_facet Cavero-Redondo, Iván
Saz-Lara, Alicia
Martínez-García, Irene
Bizzozero-Peroni, Bruno
Díaz-Goñi, Valentina
Díez-Fernández, Ana
Moreno-Herráiz, Nerea
Pascual-Morena, Carlos
author_sort Cavero-Redondo, Iván
collection PubMed
description (1) Background: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for approximately 50% of all patients with HF. In the absence of pharmacological treatments that have been successful in reducing mortality or morbidity in this pathology, physical exercise is recognized as an important adjunct in the treatment of HF. Therefore, the objective of this study is to compare the efficacy of combined training and high intensity interval training (HIIT) on exercise capacity, diastolic function, endothelial function, and arterial stiffness in participants with HFpEF. (2) Methods: The ExIC-FEp study will be a single-blind, 3-arm, randomized clinical trial (RCT) conducted at the Health and Social Research Center of the University of Castilla-La Mancha. Participants with HFpEF will be randomly assigned (1:1:1) to the combined exercise, HIIT or control group to evaluate the efficacy of physical exercise programs on exercise capacity, diastolic function, endothelial function, and arterial stiffness. All participants will be examined at baseline, at three months and at six months. (3) Results: The findings of this study will be published in a peer-reviewed journal. (4) Conclusions: This RCT will represent a significant advance in the available scientific evidence on the efficacy of physical exercise in the treatment of HFpEF.
format Online
Article
Text
id pubmed-10218785
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102187852023-05-27 Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial Cavero-Redondo, Iván Saz-Lara, Alicia Martínez-García, Irene Bizzozero-Peroni, Bruno Díaz-Goñi, Valentina Díez-Fernández, Ana Moreno-Herráiz, Nerea Pascual-Morena, Carlos J Clin Med Protocol (1) Background: Heart failure (HF) with preserved ejection fraction (HFpEF) accounts for approximately 50% of all patients with HF. In the absence of pharmacological treatments that have been successful in reducing mortality or morbidity in this pathology, physical exercise is recognized as an important adjunct in the treatment of HF. Therefore, the objective of this study is to compare the efficacy of combined training and high intensity interval training (HIIT) on exercise capacity, diastolic function, endothelial function, and arterial stiffness in participants with HFpEF. (2) Methods: The ExIC-FEp study will be a single-blind, 3-arm, randomized clinical trial (RCT) conducted at the Health and Social Research Center of the University of Castilla-La Mancha. Participants with HFpEF will be randomly assigned (1:1:1) to the combined exercise, HIIT or control group to evaluate the efficacy of physical exercise programs on exercise capacity, diastolic function, endothelial function, and arterial stiffness. All participants will be examined at baseline, at three months and at six months. (3) Results: The findings of this study will be published in a peer-reviewed journal. (4) Conclusions: This RCT will represent a significant advance in the available scientific evidence on the efficacy of physical exercise in the treatment of HFpEF. MDPI 2023-05-18 /pmc/articles/PMC10218785/ /pubmed/37240641 http://dx.doi.org/10.3390/jcm12103535 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Protocol
Cavero-Redondo, Iván
Saz-Lara, Alicia
Martínez-García, Irene
Bizzozero-Peroni, Bruno
Díaz-Goñi, Valentina
Díez-Fernández, Ana
Moreno-Herráiz, Nerea
Pascual-Morena, Carlos
Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial
title Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial
title_full Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial
title_fullStr Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial
title_full_unstemmed Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial
title_short Comparative Effect of Two Types of Physical Exercise for the Improvement of Exercise Capacity, Diastolic Function, Endothelial Function and Arterial Stiffness in Participants with Heart Failure with Preserved Ejection Fraction (ExIC-FEp Study): Protocol for a Randomized Controlled Trial
title_sort comparative effect of two types of physical exercise for the improvement of exercise capacity, diastolic function, endothelial function and arterial stiffness in participants with heart failure with preserved ejection fraction (exic-fep study): protocol for a randomized controlled trial
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218785/
https://www.ncbi.nlm.nih.gov/pubmed/37240641
http://dx.doi.org/10.3390/jcm12103535
work_keys_str_mv AT caveroredondoivan comparativeeffectoftwotypesofphysicalexercisefortheimprovementofexercisecapacitydiastolicfunctionendothelialfunctionandarterialstiffnessinparticipantswithheartfailurewithpreservedejectionfractionexicfepstudyprotocolforarandomizedcontrolledtrial
AT sazlaraalicia comparativeeffectoftwotypesofphysicalexercisefortheimprovementofexercisecapacitydiastolicfunctionendothelialfunctionandarterialstiffnessinparticipantswithheartfailurewithpreservedejectionfractionexicfepstudyprotocolforarandomizedcontrolledtrial
AT martinezgarciairene comparativeeffectoftwotypesofphysicalexercisefortheimprovementofexercisecapacitydiastolicfunctionendothelialfunctionandarterialstiffnessinparticipantswithheartfailurewithpreservedejectionfractionexicfepstudyprotocolforarandomizedcontrolledtrial
AT bizzozeroperonibruno comparativeeffectoftwotypesofphysicalexercisefortheimprovementofexercisecapacitydiastolicfunctionendothelialfunctionandarterialstiffnessinparticipantswithheartfailurewithpreservedejectionfractionexicfepstudyprotocolforarandomizedcontrolledtrial
AT diazgonivalentina comparativeeffectoftwotypesofphysicalexercisefortheimprovementofexercisecapacitydiastolicfunctionendothelialfunctionandarterialstiffnessinparticipantswithheartfailurewithpreservedejectionfractionexicfepstudyprotocolforarandomizedcontrolledtrial
AT diezfernandezana comparativeeffectoftwotypesofphysicalexercisefortheimprovementofexercisecapacitydiastolicfunctionendothelialfunctionandarterialstiffnessinparticipantswithheartfailurewithpreservedejectionfractionexicfepstudyprotocolforarandomizedcontrolledtrial
AT morenoherraiznerea comparativeeffectoftwotypesofphysicalexercisefortheimprovementofexercisecapacitydiastolicfunctionendothelialfunctionandarterialstiffnessinparticipantswithheartfailurewithpreservedejectionfractionexicfepstudyprotocolforarandomizedcontrolledtrial
AT pascualmorenacarlos comparativeeffectoftwotypesofphysicalexercisefortheimprovementofexercisecapacitydiastolicfunctionendothelialfunctionandarterialstiffnessinparticipantswithheartfailurewithpreservedejectionfractionexicfepstudyprotocolforarandomizedcontrolledtrial