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Differences in Selective Attention and Inhibitory Control in Patients with Major Depressive Disorder and Healthy Controls Who Do Not Engage in Sufficient Physical Activity

Background: Patients with major depressive disorder (MDD) are characterized by neurocognitive impairments and show deficits in various cognitive performance indicators, including executive function. We examined whether sustained attention and inhibitory control differ between patients with MDD and h...

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Autores principales: Gerber, Markus, Cody, Robyn, Beck, Johannes, Brand, Serge, Donath, Lars, Eckert, Anne, Faude, Oliver, Hatzinger, Martin, Imboden, Christian, Kreppke, Jan-Niklas, Lang, Undine E., Mans, Sarah, Mikoteit, Thorsten, Oswald, Anja, Schweinfurth-Keck, Nina, Zahner, Lukas, Ludyga, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218814/
https://www.ncbi.nlm.nih.gov/pubmed/37240475
http://dx.doi.org/10.3390/jcm12103370
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author Gerber, Markus
Cody, Robyn
Beck, Johannes
Brand, Serge
Donath, Lars
Eckert, Anne
Faude, Oliver
Hatzinger, Martin
Imboden, Christian
Kreppke, Jan-Niklas
Lang, Undine E.
Mans, Sarah
Mikoteit, Thorsten
Oswald, Anja
Schweinfurth-Keck, Nina
Zahner, Lukas
Ludyga, Sebastian
author_facet Gerber, Markus
Cody, Robyn
Beck, Johannes
Brand, Serge
Donath, Lars
Eckert, Anne
Faude, Oliver
Hatzinger, Martin
Imboden, Christian
Kreppke, Jan-Niklas
Lang, Undine E.
Mans, Sarah
Mikoteit, Thorsten
Oswald, Anja
Schweinfurth-Keck, Nina
Zahner, Lukas
Ludyga, Sebastian
author_sort Gerber, Markus
collection PubMed
description Background: Patients with major depressive disorder (MDD) are characterized by neurocognitive impairments and show deficits in various cognitive performance indicators, including executive function. We examined whether sustained attention and inhibitory control differ between patients with MDD and healthy controls, and whether differences exist between patients with mild, moderate, and severe depression. Methods: Clinical in-patients (N = 212) aged 18–65 years with a current diagnosis of MDD and 128 healthy controls were recruited. Depression severity was assessed using the Beck Depression Inventory, and sustained attention and inhibitory control were assessed using the oddball and flanker tasks. The use of these tasks promises insights into executive function in depressive patients that are not biased by verbal skills. Group differences were tested via analyses of covariance. Results: Patients with MDD showed slower reaction times in both the oddball and flanker task, independent of the executive demands of the trial types. Younger participants achieved shorter reaction times in both inhibitory control tasks. After correcting for age, education, smoking, BMI, and nationality, only differences in reaction times in the oddball task were statistically significant. In contrast, reaction times were not sensitive to the symptom severity of depression. Conclusion: Our results corroborate deficits in basic information processing and specific impairments in higher-order cognitive processes in MDD patients. As difficulties in executive function underlie problems in planning, initiating, and completing goal-directed activities, they may jeopardize in-patient treatment and contribute to the recurrent nature of depression.
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spelling pubmed-102188142023-05-27 Differences in Selective Attention and Inhibitory Control in Patients with Major Depressive Disorder and Healthy Controls Who Do Not Engage in Sufficient Physical Activity Gerber, Markus Cody, Robyn Beck, Johannes Brand, Serge Donath, Lars Eckert, Anne Faude, Oliver Hatzinger, Martin Imboden, Christian Kreppke, Jan-Niklas Lang, Undine E. Mans, Sarah Mikoteit, Thorsten Oswald, Anja Schweinfurth-Keck, Nina Zahner, Lukas Ludyga, Sebastian J Clin Med Article Background: Patients with major depressive disorder (MDD) are characterized by neurocognitive impairments and show deficits in various cognitive performance indicators, including executive function. We examined whether sustained attention and inhibitory control differ between patients with MDD and healthy controls, and whether differences exist between patients with mild, moderate, and severe depression. Methods: Clinical in-patients (N = 212) aged 18–65 years with a current diagnosis of MDD and 128 healthy controls were recruited. Depression severity was assessed using the Beck Depression Inventory, and sustained attention and inhibitory control were assessed using the oddball and flanker tasks. The use of these tasks promises insights into executive function in depressive patients that are not biased by verbal skills. Group differences were tested via analyses of covariance. Results: Patients with MDD showed slower reaction times in both the oddball and flanker task, independent of the executive demands of the trial types. Younger participants achieved shorter reaction times in both inhibitory control tasks. After correcting for age, education, smoking, BMI, and nationality, only differences in reaction times in the oddball task were statistically significant. In contrast, reaction times were not sensitive to the symptom severity of depression. Conclusion: Our results corroborate deficits in basic information processing and specific impairments in higher-order cognitive processes in MDD patients. As difficulties in executive function underlie problems in planning, initiating, and completing goal-directed activities, they may jeopardize in-patient treatment and contribute to the recurrent nature of depression. MDPI 2023-05-09 /pmc/articles/PMC10218814/ /pubmed/37240475 http://dx.doi.org/10.3390/jcm12103370 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gerber, Markus
Cody, Robyn
Beck, Johannes
Brand, Serge
Donath, Lars
Eckert, Anne
Faude, Oliver
Hatzinger, Martin
Imboden, Christian
Kreppke, Jan-Niklas
Lang, Undine E.
Mans, Sarah
Mikoteit, Thorsten
Oswald, Anja
Schweinfurth-Keck, Nina
Zahner, Lukas
Ludyga, Sebastian
Differences in Selective Attention and Inhibitory Control in Patients with Major Depressive Disorder and Healthy Controls Who Do Not Engage in Sufficient Physical Activity
title Differences in Selective Attention and Inhibitory Control in Patients with Major Depressive Disorder and Healthy Controls Who Do Not Engage in Sufficient Physical Activity
title_full Differences in Selective Attention and Inhibitory Control in Patients with Major Depressive Disorder and Healthy Controls Who Do Not Engage in Sufficient Physical Activity
title_fullStr Differences in Selective Attention and Inhibitory Control in Patients with Major Depressive Disorder and Healthy Controls Who Do Not Engage in Sufficient Physical Activity
title_full_unstemmed Differences in Selective Attention and Inhibitory Control in Patients with Major Depressive Disorder and Healthy Controls Who Do Not Engage in Sufficient Physical Activity
title_short Differences in Selective Attention and Inhibitory Control in Patients with Major Depressive Disorder and Healthy Controls Who Do Not Engage in Sufficient Physical Activity
title_sort differences in selective attention and inhibitory control in patients with major depressive disorder and healthy controls who do not engage in sufficient physical activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218814/
https://www.ncbi.nlm.nih.gov/pubmed/37240475
http://dx.doi.org/10.3390/jcm12103370
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