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Calcium’s Role in Orchestrating Cancer Apoptosis: Mitochondrial-Centric Perspective

Calcium is an essential intracellular messenger that plays a vital role in controlling a broad range of cellular processes, including apoptosis. This review offers an in-depth analysis of calcium’s multifaceted role in apoptosis regulation, focusing on the associated signaling pathways and molecular...

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Detalles Bibliográficos
Autor principal: Moon, Dong-Oh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218825/
https://www.ncbi.nlm.nih.gov/pubmed/37240331
http://dx.doi.org/10.3390/ijms24108982
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author Moon, Dong-Oh
author_facet Moon, Dong-Oh
author_sort Moon, Dong-Oh
collection PubMed
description Calcium is an essential intracellular messenger that plays a vital role in controlling a broad range of cellular processes, including apoptosis. This review offers an in-depth analysis of calcium’s multifaceted role in apoptosis regulation, focusing on the associated signaling pathways and molecular mechanisms. We will explore calcium’s impact on apoptosis through its effects on different cellular compartments, such as the mitochondria and endoplasmic reticulum (ER), and discuss the connection between calcium homeostasis and ER stress. Additionally, we will highlight the interplay between calcium and various proteins, including calpains, calmodulin, and Bcl-2 family members, and the role of calcium in regulating caspase activation and pro-apoptotic factor release. By investigating the complex relationship between calcium and apoptosis, this review aims to deepen our comprehension of the fundamental processes, and pinpointing possible treatment options for illnesses associated with imbalanced cell death is crucial.
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spelling pubmed-102188252023-05-27 Calcium’s Role in Orchestrating Cancer Apoptosis: Mitochondrial-Centric Perspective Moon, Dong-Oh Int J Mol Sci Review Calcium is an essential intracellular messenger that plays a vital role in controlling a broad range of cellular processes, including apoptosis. This review offers an in-depth analysis of calcium’s multifaceted role in apoptosis regulation, focusing on the associated signaling pathways and molecular mechanisms. We will explore calcium’s impact on apoptosis through its effects on different cellular compartments, such as the mitochondria and endoplasmic reticulum (ER), and discuss the connection between calcium homeostasis and ER stress. Additionally, we will highlight the interplay between calcium and various proteins, including calpains, calmodulin, and Bcl-2 family members, and the role of calcium in regulating caspase activation and pro-apoptotic factor release. By investigating the complex relationship between calcium and apoptosis, this review aims to deepen our comprehension of the fundamental processes, and pinpointing possible treatment options for illnesses associated with imbalanced cell death is crucial. MDPI 2023-05-19 /pmc/articles/PMC10218825/ /pubmed/37240331 http://dx.doi.org/10.3390/ijms24108982 Text en © 2023 by the author. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Moon, Dong-Oh
Calcium’s Role in Orchestrating Cancer Apoptosis: Mitochondrial-Centric Perspective
title Calcium’s Role in Orchestrating Cancer Apoptosis: Mitochondrial-Centric Perspective
title_full Calcium’s Role in Orchestrating Cancer Apoptosis: Mitochondrial-Centric Perspective
title_fullStr Calcium’s Role in Orchestrating Cancer Apoptosis: Mitochondrial-Centric Perspective
title_full_unstemmed Calcium’s Role in Orchestrating Cancer Apoptosis: Mitochondrial-Centric Perspective
title_short Calcium’s Role in Orchestrating Cancer Apoptosis: Mitochondrial-Centric Perspective
title_sort calcium’s role in orchestrating cancer apoptosis: mitochondrial-centric perspective
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218825/
https://www.ncbi.nlm.nih.gov/pubmed/37240331
http://dx.doi.org/10.3390/ijms24108982
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