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A Novel Approach to Staging and Detection of Colorectal Cancer in Early Stages

Colorectal cancer (CRC) is a significant problem affecting patients all over the world. Since it is the fourth most common cause of cancer-related deaths, many scientists aim to expand their knowledge on the detection in early stages and treatment of this disease. Chemokines, as protein parameters i...

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Autores principales: Zajkowska, Monika, Mroczko, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218832/
https://www.ncbi.nlm.nih.gov/pubmed/37240636
http://dx.doi.org/10.3390/jcm12103530
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author Zajkowska, Monika
Mroczko, Barbara
author_facet Zajkowska, Monika
Mroczko, Barbara
author_sort Zajkowska, Monika
collection PubMed
description Colorectal cancer (CRC) is a significant problem affecting patients all over the world. Since it is the fourth most common cause of cancer-related deaths, many scientists aim to expand their knowledge on the detection in early stages and treatment of this disease. Chemokines, as protein parameters involved in many processes accompanying the development of cancer, constitute a group of potential biomarkers that could also be useful in the detection of CRC. For this purpose, our research team used the results of thirteen parameters (nine chemokines, one chemokine receptor and three comparative markers, i.e., CEA, CA19-9 and CRP) to calculate one hundred and fifty indexes. Moreover, for the first time, the relationship between these parameters during the ongoing cancer process and in comparison to a control group are presented. As a result of statistical analyses using patients’ clinical data and the obtained indexes, it was established that several of the indexes have a diagnostic utility that is much higher than the tumor marker that is currently the most commonly used (CEA) currently. Furthermore, two of the indexes (CXCL14/CEA and CXCL16/CEA) showed not only extremely high usefulness in the detection of CRC in its early stages, but also the ability to determine whether the stage is low (stage I and II) or high (stage III and IV).
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spelling pubmed-102188322023-05-27 A Novel Approach to Staging and Detection of Colorectal Cancer in Early Stages Zajkowska, Monika Mroczko, Barbara J Clin Med Article Colorectal cancer (CRC) is a significant problem affecting patients all over the world. Since it is the fourth most common cause of cancer-related deaths, many scientists aim to expand their knowledge on the detection in early stages and treatment of this disease. Chemokines, as protein parameters involved in many processes accompanying the development of cancer, constitute a group of potential biomarkers that could also be useful in the detection of CRC. For this purpose, our research team used the results of thirteen parameters (nine chemokines, one chemokine receptor and three comparative markers, i.e., CEA, CA19-9 and CRP) to calculate one hundred and fifty indexes. Moreover, for the first time, the relationship between these parameters during the ongoing cancer process and in comparison to a control group are presented. As a result of statistical analyses using patients’ clinical data and the obtained indexes, it was established that several of the indexes have a diagnostic utility that is much higher than the tumor marker that is currently the most commonly used (CEA) currently. Furthermore, two of the indexes (CXCL14/CEA and CXCL16/CEA) showed not only extremely high usefulness in the detection of CRC in its early stages, but also the ability to determine whether the stage is low (stage I and II) or high (stage III and IV). MDPI 2023-05-17 /pmc/articles/PMC10218832/ /pubmed/37240636 http://dx.doi.org/10.3390/jcm12103530 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zajkowska, Monika
Mroczko, Barbara
A Novel Approach to Staging and Detection of Colorectal Cancer in Early Stages
title A Novel Approach to Staging and Detection of Colorectal Cancer in Early Stages
title_full A Novel Approach to Staging and Detection of Colorectal Cancer in Early Stages
title_fullStr A Novel Approach to Staging and Detection of Colorectal Cancer in Early Stages
title_full_unstemmed A Novel Approach to Staging and Detection of Colorectal Cancer in Early Stages
title_short A Novel Approach to Staging and Detection of Colorectal Cancer in Early Stages
title_sort novel approach to staging and detection of colorectal cancer in early stages
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218832/
https://www.ncbi.nlm.nih.gov/pubmed/37240636
http://dx.doi.org/10.3390/jcm12103530
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