Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems

A dual-target strategy was designed for the application of lignin nanoparticles in the lipase mediated biosynthesis of novel 3-O-ethyl-L-ascorbyl-6-ferulate and 3-O-ethyl-L-ascorbyl-6-palmitate and in their successive solvent-shift encapsulation in order to improve stability and antioxidant activity...

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Autores principales: Capecchi, Eliana, Piccinino, Davide, Nascimben, Chiara, Tomaino, Elisabetta, Ceccotti Vlas, Natalia, Gabellone, Sofia, Saladino, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218833/
https://www.ncbi.nlm.nih.gov/pubmed/37240391
http://dx.doi.org/10.3390/ijms24109044
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author Capecchi, Eliana
Piccinino, Davide
Nascimben, Chiara
Tomaino, Elisabetta
Ceccotti Vlas, Natalia
Gabellone, Sofia
Saladino, Raffaele
author_facet Capecchi, Eliana
Piccinino, Davide
Nascimben, Chiara
Tomaino, Elisabetta
Ceccotti Vlas, Natalia
Gabellone, Sofia
Saladino, Raffaele
author_sort Capecchi, Eliana
collection PubMed
description A dual-target strategy was designed for the application of lignin nanoparticles in the lipase mediated biosynthesis of novel 3-O-ethyl-L-ascorbyl-6-ferulate and 3-O-ethyl-L-ascorbyl-6-palmitate and in their successive solvent-shift encapsulation in order to improve stability and antioxidant activity against temperature and pH-dependent degradation. The loaded lignin nanoparticles were fully characterized in terms of kinetic release, radical scavenging activity and stability under pH 3 and thermal stress (60 °C), showing improved antioxidant activity and high efficacy in the protection of ascorbic acid esters from degradation.
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spelling pubmed-102188332023-05-27 Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems Capecchi, Eliana Piccinino, Davide Nascimben, Chiara Tomaino, Elisabetta Ceccotti Vlas, Natalia Gabellone, Sofia Saladino, Raffaele Int J Mol Sci Article A dual-target strategy was designed for the application of lignin nanoparticles in the lipase mediated biosynthesis of novel 3-O-ethyl-L-ascorbyl-6-ferulate and 3-O-ethyl-L-ascorbyl-6-palmitate and in their successive solvent-shift encapsulation in order to improve stability and antioxidant activity against temperature and pH-dependent degradation. The loaded lignin nanoparticles were fully characterized in terms of kinetic release, radical scavenging activity and stability under pH 3 and thermal stress (60 °C), showing improved antioxidant activity and high efficacy in the protection of ascorbic acid esters from degradation. MDPI 2023-05-20 /pmc/articles/PMC10218833/ /pubmed/37240391 http://dx.doi.org/10.3390/ijms24109044 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Capecchi, Eliana
Piccinino, Davide
Nascimben, Chiara
Tomaino, Elisabetta
Ceccotti Vlas, Natalia
Gabellone, Sofia
Saladino, Raffaele
Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems
title Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems
title_full Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems
title_fullStr Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems
title_full_unstemmed Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems
title_short Biosynthesis of Novel Ascorbic Acid Esters and Their Encapsulation in Lignin Nanoparticles as Carriers and Stabilizing Systems
title_sort biosynthesis of novel ascorbic acid esters and their encapsulation in lignin nanoparticles as carriers and stabilizing systems
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218833/
https://www.ncbi.nlm.nih.gov/pubmed/37240391
http://dx.doi.org/10.3390/ijms24109044
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