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Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis

Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small...

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Autores principales: Bettiol, Alessandra, Fagni, Filippo, Mattioli, Irene, Bagni, Giacomo, Vitiello, Gianfranco, Grassi, Alessia, Della Bella, Chiara, Benagiano, Marisa, Troilo, Arianna, Holownia, Katarzyna Stella, Simon, David, Argento, Flavia Rita, Sota, Jurgen, Fabiani, Claudia, Becatti, Matteo, Fiorillo, Claudia, Schett, Georg, Lopalco, Giuseppe, Cantarini, Luca, Prisco, Domenico, Silvestri, Elena, Emmi, Giacomo, D’Elios, Mario Milco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218865/
https://www.ncbi.nlm.nih.gov/pubmed/37240162
http://dx.doi.org/10.3390/ijms24108817
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author Bettiol, Alessandra
Fagni, Filippo
Mattioli, Irene
Bagni, Giacomo
Vitiello, Gianfranco
Grassi, Alessia
Della Bella, Chiara
Benagiano, Marisa
Troilo, Arianna
Holownia, Katarzyna Stella
Simon, David
Argento, Flavia Rita
Sota, Jurgen
Fabiani, Claudia
Becatti, Matteo
Fiorillo, Claudia
Schett, Georg
Lopalco, Giuseppe
Cantarini, Luca
Prisco, Domenico
Silvestri, Elena
Emmi, Giacomo
D’Elios, Mario Milco
author_facet Bettiol, Alessandra
Fagni, Filippo
Mattioli, Irene
Bagni, Giacomo
Vitiello, Gianfranco
Grassi, Alessia
Della Bella, Chiara
Benagiano, Marisa
Troilo, Arianna
Holownia, Katarzyna Stella
Simon, David
Argento, Flavia Rita
Sota, Jurgen
Fabiani, Claudia
Becatti, Matteo
Fiorillo, Claudia
Schett, Georg
Lopalco, Giuseppe
Cantarini, Luca
Prisco, Domenico
Silvestri, Elena
Emmi, Giacomo
D’Elios, Mario Milco
author_sort Bettiol, Alessandra
collection PubMed
description Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS.
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spelling pubmed-102188652023-05-27 Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis Bettiol, Alessandra Fagni, Filippo Mattioli, Irene Bagni, Giacomo Vitiello, Gianfranco Grassi, Alessia Della Bella, Chiara Benagiano, Marisa Troilo, Arianna Holownia, Katarzyna Stella Simon, David Argento, Flavia Rita Sota, Jurgen Fabiani, Claudia Becatti, Matteo Fiorillo, Claudia Schett, Georg Lopalco, Giuseppe Cantarini, Luca Prisco, Domenico Silvestri, Elena Emmi, Giacomo D’Elios, Mario Milco Int J Mol Sci Article Behçet’s syndrome (BS) is a rare systemic vasculitis characterized by different clinical manifestations. As no specific laboratory tests exist, the diagnosis relies on clinical criteria, and the differential diagnosis with other inflammatory diseases can be challenging. Indeed, in a relatively small proportion of patients, BS symptoms include only mucocutaneous, articular, gastrointestinal, and non-typical ocular manifestations, which are frequently found also in psoriatic arthritis (PsA). We investigate the ability of serum interleukin (IL)-36α—a pro-inflammatory cytokine involved in cutaneous and articular inflammatory diseases—to differentiate BS from PsA. A cross-sectional study was performed on 90 patients with BS, 80 with PsA and 80 healthy controls. Significantly lower IL-36α concentrations were found in patients with BS as compared to PsA, although in both groups IL-36α was significantly increased compared to healthy controls. An empirical cut-off of 420.6 pg/mL displayed a specificity of 0.93, with a sensitivity of 0.70 (AUC 0.82) in discriminating PsA from BS. This cut-off displayed a good diagnostic performance also in BS patients lacking highly specific BS manifestations. Our results indicate that IL-36α might be involved in the pathogenesis of both BS and PsA, and might be a candidate biomarker to support the differential diagnosis of BS. MDPI 2023-05-16 /pmc/articles/PMC10218865/ /pubmed/37240162 http://dx.doi.org/10.3390/ijms24108817 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bettiol, Alessandra
Fagni, Filippo
Mattioli, Irene
Bagni, Giacomo
Vitiello, Gianfranco
Grassi, Alessia
Della Bella, Chiara
Benagiano, Marisa
Troilo, Arianna
Holownia, Katarzyna Stella
Simon, David
Argento, Flavia Rita
Sota, Jurgen
Fabiani, Claudia
Becatti, Matteo
Fiorillo, Claudia
Schett, Georg
Lopalco, Giuseppe
Cantarini, Luca
Prisco, Domenico
Silvestri, Elena
Emmi, Giacomo
D’Elios, Mario Milco
Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
title Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
title_full Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
title_fullStr Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
title_full_unstemmed Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
title_short Serum Interleukin-36 α as a Candidate Biomarker to Distinguish Behçet’s Syndrome and Psoriatic Arthritis
title_sort serum interleukin-36 α as a candidate biomarker to distinguish behçet’s syndrome and psoriatic arthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218865/
https://www.ncbi.nlm.nih.gov/pubmed/37240162
http://dx.doi.org/10.3390/ijms24108817
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