Recent Advances and Potential Multi-Omics Approaches in the Early Phases of Inflammatory Bowel Disease

Inflammatory bowel disease leads to debilitating gastrointestinal symptoms and reduced quality of life, resulting in a significant burden on healthcare utilization and costs. Despite substantial advancements in diagnosis and treatment, there may still be considerable delays in diagnosing some patien...

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Autores principales: Rodríguez-Lago, Iago, Blackwell, Jonathan, Mateos, Beatriz, Marigorta, Urko M., Barreiro-de Acosta, Manuel, Pollok, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218872/
https://www.ncbi.nlm.nih.gov/pubmed/37240524
http://dx.doi.org/10.3390/jcm12103418
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author Rodríguez-Lago, Iago
Blackwell, Jonathan
Mateos, Beatriz
Marigorta, Urko M.
Barreiro-de Acosta, Manuel
Pollok, Richard
author_facet Rodríguez-Lago, Iago
Blackwell, Jonathan
Mateos, Beatriz
Marigorta, Urko M.
Barreiro-de Acosta, Manuel
Pollok, Richard
author_sort Rodríguez-Lago, Iago
collection PubMed
description Inflammatory bowel disease leads to debilitating gastrointestinal symptoms and reduced quality of life, resulting in a significant burden on healthcare utilization and costs. Despite substantial advancements in diagnosis and treatment, there may still be considerable delays in diagnosing some patients. To reduce disease progression before the full disease spectrum appears and improve prognostic outcomes, several strategies have concentrated on early intervention and prevention. Recent evidence shows that initial immune response changes and endoscopic lesions may exist for years before diagnosis, implying the existence of a preclinical phase of inflammatory bowel disease comparable to findings in other immune-mediated disorders. In this review, we highlight the most relevant findings regarding preclinical inflammatory bowel disease and the prospective role of novel omics techniques in this field.
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spelling pubmed-102188722023-05-27 Recent Advances and Potential Multi-Omics Approaches in the Early Phases of Inflammatory Bowel Disease Rodríguez-Lago, Iago Blackwell, Jonathan Mateos, Beatriz Marigorta, Urko M. Barreiro-de Acosta, Manuel Pollok, Richard J Clin Med Review Inflammatory bowel disease leads to debilitating gastrointestinal symptoms and reduced quality of life, resulting in a significant burden on healthcare utilization and costs. Despite substantial advancements in diagnosis and treatment, there may still be considerable delays in diagnosing some patients. To reduce disease progression before the full disease spectrum appears and improve prognostic outcomes, several strategies have concentrated on early intervention and prevention. Recent evidence shows that initial immune response changes and endoscopic lesions may exist for years before diagnosis, implying the existence of a preclinical phase of inflammatory bowel disease comparable to findings in other immune-mediated disorders. In this review, we highlight the most relevant findings regarding preclinical inflammatory bowel disease and the prospective role of novel omics techniques in this field. MDPI 2023-05-11 /pmc/articles/PMC10218872/ /pubmed/37240524 http://dx.doi.org/10.3390/jcm12103418 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Rodríguez-Lago, Iago
Blackwell, Jonathan
Mateos, Beatriz
Marigorta, Urko M.
Barreiro-de Acosta, Manuel
Pollok, Richard
Recent Advances and Potential Multi-Omics Approaches in the Early Phases of Inflammatory Bowel Disease
title Recent Advances and Potential Multi-Omics Approaches in the Early Phases of Inflammatory Bowel Disease
title_full Recent Advances and Potential Multi-Omics Approaches in the Early Phases of Inflammatory Bowel Disease
title_fullStr Recent Advances and Potential Multi-Omics Approaches in the Early Phases of Inflammatory Bowel Disease
title_full_unstemmed Recent Advances and Potential Multi-Omics Approaches in the Early Phases of Inflammatory Bowel Disease
title_short Recent Advances and Potential Multi-Omics Approaches in the Early Phases of Inflammatory Bowel Disease
title_sort recent advances and potential multi-omics approaches in the early phases of inflammatory bowel disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218872/
https://www.ncbi.nlm.nih.gov/pubmed/37240524
http://dx.doi.org/10.3390/jcm12103418
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