Cargando…

Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review

Hydrogels exhibit excellent moldability, biodegradability, biocompatibility, and extracellular matrix-like properties, which make them widely used in biomedical fields. Because of their unique three-dimensional crosslinked hydrophilic networks, hydrogels can encapsulate various materials, such as sm...

Descripción completa

Detalles Bibliográficos
Autores principales: Peng, Tai, Shi, Qi, Chen, Manlong, Yu, Wenyi, Yang, Tingting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218873/
https://www.ncbi.nlm.nih.gov/pubmed/37233353
http://dx.doi.org/10.3390/jfb14050243
_version_ 1785048877113540608
author Peng, Tai
Shi, Qi
Chen, Manlong
Yu, Wenyi
Yang, Tingting
author_facet Peng, Tai
Shi, Qi
Chen, Manlong
Yu, Wenyi
Yang, Tingting
author_sort Peng, Tai
collection PubMed
description Hydrogels exhibit excellent moldability, biodegradability, biocompatibility, and extracellular matrix-like properties, which make them widely used in biomedical fields. Because of their unique three-dimensional crosslinked hydrophilic networks, hydrogels can encapsulate various materials, such as small molecules, polymers, and particles; this has become a hot research topic in the antibacterial field. The surface modification of biomaterials by using antibacterial hydrogels as coatings contributes to the biomaterial activity and offers wide prospects for development. A variety of surface chemical strategies have been developed to bind hydrogels to the substrate surface stably. We first introduce the preparation method for antibacterial coatings in this review, which includes surface-initiated graft crosslinking polymerization, anchoring the hydrogel coating to the substrate surface, and the LbL self-assembly technique to coat crosslinked hydrogels. Then, we summarize the applications of hydrogel coating in the biomedical antibacterial field. Hydrogel itself has certain antibacterial properties, but the antibacterial effect is not sufficient. In recent research, in order to optimize its antibacterial performance, the following three antibacterial strategies are mainly adopted: bacterial repellent and inhibition, contact surface killing of bacteria, and release of antibacterial agents. We systematically introduce the antibacterial mechanism of each strategy. The review aims to provide reference for the further development and application of hydrogel coatings.
format Online
Article
Text
id pubmed-10218873
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102188732023-05-27 Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review Peng, Tai Shi, Qi Chen, Manlong Yu, Wenyi Yang, Tingting J Funct Biomater Review Hydrogels exhibit excellent moldability, biodegradability, biocompatibility, and extracellular matrix-like properties, which make them widely used in biomedical fields. Because of their unique three-dimensional crosslinked hydrophilic networks, hydrogels can encapsulate various materials, such as small molecules, polymers, and particles; this has become a hot research topic in the antibacterial field. The surface modification of biomaterials by using antibacterial hydrogels as coatings contributes to the biomaterial activity and offers wide prospects for development. A variety of surface chemical strategies have been developed to bind hydrogels to the substrate surface stably. We first introduce the preparation method for antibacterial coatings in this review, which includes surface-initiated graft crosslinking polymerization, anchoring the hydrogel coating to the substrate surface, and the LbL self-assembly technique to coat crosslinked hydrogels. Then, we summarize the applications of hydrogel coating in the biomedical antibacterial field. Hydrogel itself has certain antibacterial properties, but the antibacterial effect is not sufficient. In recent research, in order to optimize its antibacterial performance, the following three antibacterial strategies are mainly adopted: bacterial repellent and inhibition, contact surface killing of bacteria, and release of antibacterial agents. We systematically introduce the antibacterial mechanism of each strategy. The review aims to provide reference for the further development and application of hydrogel coatings. MDPI 2023-04-25 /pmc/articles/PMC10218873/ /pubmed/37233353 http://dx.doi.org/10.3390/jfb14050243 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Peng, Tai
Shi, Qi
Chen, Manlong
Yu, Wenyi
Yang, Tingting
Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review
title Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review
title_full Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review
title_fullStr Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review
title_full_unstemmed Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review
title_short Antibacterial-Based Hydrogel Coatings and Their Application in the Biomedical Field—A Review
title_sort antibacterial-based hydrogel coatings and their application in the biomedical field—a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218873/
https://www.ncbi.nlm.nih.gov/pubmed/37233353
http://dx.doi.org/10.3390/jfb14050243
work_keys_str_mv AT pengtai antibacterialbasedhydrogelcoatingsandtheirapplicationinthebiomedicalfieldareview
AT shiqi antibacterialbasedhydrogelcoatingsandtheirapplicationinthebiomedicalfieldareview
AT chenmanlong antibacterialbasedhydrogelcoatingsandtheirapplicationinthebiomedicalfieldareview
AT yuwenyi antibacterialbasedhydrogelcoatingsandtheirapplicationinthebiomedicalfieldareview
AT yangtingting antibacterialbasedhydrogelcoatingsandtheirapplicationinthebiomedicalfieldareview