Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAF(V600E) Inhibitors

Some new Bis-pyrazoline hybrids 8–17 with dual EGFR and BRAF(V600E) inhibitors have been developed. The target compounds were synthesized and tested in vitro against four cancer cell lines. Compounds 12, 15, and 17 demonstrated strong antiproliferative activity with GI(50) values of 1.05 µM, 1.50 µM...

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Detalles Bibliográficos
Autores principales: Al-Wahaibi, Lamya H., Abou-Zied, Hesham A., Beshr, Eman A. M., Youssif, Bahaa G. M., Hayallah, Alaa M., Abdel-Aziz, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218941/
https://www.ncbi.nlm.nih.gov/pubmed/37240450
http://dx.doi.org/10.3390/ijms24109104

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218941/
https://www.ncbi.nlm.nih.gov/pubmed/37240450
http://dx.doi.org/10.3390/ijms24109104

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