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Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAF(V600E) Inhibitors
Some new Bis-pyrazoline hybrids 8–17 with dual EGFR and BRAF(V600E) inhibitors have been developed. The target compounds were synthesized and tested in vitro against four cancer cell lines. Compounds 12, 15, and 17 demonstrated strong antiproliferative activity with GI(50) values of 1.05 µM, 1.50 µM...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218941/ https://www.ncbi.nlm.nih.gov/pubmed/37240450 http://dx.doi.org/10.3390/ijms24109104 |