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Epigenetic Analysis of the Dopamine Transporter Gene DAT1 with a Focus on Personality Traits in Athletes

Human phenotypes (traits) are determined by the selective use of a person’s unique genotype (DNA sequence), following exposure to environmental stimuli, such as exercise. Inducing profound changes in epigenetics may be an underlying factor of the beneficial effects of exercise. This study aimed to i...

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Autores principales: Humińska-Lisowska, Kinga, Chmielowiec, Krzysztof, Strońska-Pluta, Aleksandra, Chmielowiec, Jolanta, Suchanecka, Aleksandra, Masiak, Jolanta, Michałowska-Sawczyn, Monika, Boroń, Agnieszka, Cięszczyk, Paweł, Grzywacz, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218950/
https://www.ncbi.nlm.nih.gov/pubmed/37240274
http://dx.doi.org/10.3390/ijms24108931
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author Humińska-Lisowska, Kinga
Chmielowiec, Krzysztof
Strońska-Pluta, Aleksandra
Chmielowiec, Jolanta
Suchanecka, Aleksandra
Masiak, Jolanta
Michałowska-Sawczyn, Monika
Boroń, Agnieszka
Cięszczyk, Paweł
Grzywacz, Anna
author_facet Humińska-Lisowska, Kinga
Chmielowiec, Krzysztof
Strońska-Pluta, Aleksandra
Chmielowiec, Jolanta
Suchanecka, Aleksandra
Masiak, Jolanta
Michałowska-Sawczyn, Monika
Boroń, Agnieszka
Cięszczyk, Paweł
Grzywacz, Anna
author_sort Humińska-Lisowska, Kinga
collection PubMed
description Human phenotypes (traits) are determined by the selective use of a person’s unique genotype (DNA sequence), following exposure to environmental stimuli, such as exercise. Inducing profound changes in epigenetics may be an underlying factor of the beneficial effects of exercise. This study aimed to investigate the association between methylation in the promoter region of the DAT1 gene and personality traits measured by the NEO-FFI questionnaire in a group of athletes. The study group included 163 athletes, and the control group consisted of 232 non-athletes. The obtained results show several significant differences between the studied groups of subjects. The Extraversion scale and the Conscientiousness scale results of the NEO-FFI are significantly higher in the group of athletes compared to controls. The total methylation and the number of methylated islands in the promoter region of the DAT1 gene are higher in the study group. Pearson’s linear correlation between the total methylation, the number of methylated islands and the NEO-FFI shows significant results for the Extraversion and Agreeability scales. The total methylation and the number of methylated islands in the promoter region of the DAT1 gene are higher in the study group. Pearson’s linear correlation between the total methylation, the number of methylated islands and the NEO-FFI shows significant results for the Extraversion and Agreeability scales. Our analysis of the methylation status of individual CpG sites revealed a new direction of research into the biological aspects of regulating dopamine release and personality traits in people practicing sports.
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spelling pubmed-102189502023-05-27 Epigenetic Analysis of the Dopamine Transporter Gene DAT1 with a Focus on Personality Traits in Athletes Humińska-Lisowska, Kinga Chmielowiec, Krzysztof Strońska-Pluta, Aleksandra Chmielowiec, Jolanta Suchanecka, Aleksandra Masiak, Jolanta Michałowska-Sawczyn, Monika Boroń, Agnieszka Cięszczyk, Paweł Grzywacz, Anna Int J Mol Sci Article Human phenotypes (traits) are determined by the selective use of a person’s unique genotype (DNA sequence), following exposure to environmental stimuli, such as exercise. Inducing profound changes in epigenetics may be an underlying factor of the beneficial effects of exercise. This study aimed to investigate the association between methylation in the promoter region of the DAT1 gene and personality traits measured by the NEO-FFI questionnaire in a group of athletes. The study group included 163 athletes, and the control group consisted of 232 non-athletes. The obtained results show several significant differences between the studied groups of subjects. The Extraversion scale and the Conscientiousness scale results of the NEO-FFI are significantly higher in the group of athletes compared to controls. The total methylation and the number of methylated islands in the promoter region of the DAT1 gene are higher in the study group. Pearson’s linear correlation between the total methylation, the number of methylated islands and the NEO-FFI shows significant results for the Extraversion and Agreeability scales. The total methylation and the number of methylated islands in the promoter region of the DAT1 gene are higher in the study group. Pearson’s linear correlation between the total methylation, the number of methylated islands and the NEO-FFI shows significant results for the Extraversion and Agreeability scales. Our analysis of the methylation status of individual CpG sites revealed a new direction of research into the biological aspects of regulating dopamine release and personality traits in people practicing sports. MDPI 2023-05-18 /pmc/articles/PMC10218950/ /pubmed/37240274 http://dx.doi.org/10.3390/ijms24108931 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Humińska-Lisowska, Kinga
Chmielowiec, Krzysztof
Strońska-Pluta, Aleksandra
Chmielowiec, Jolanta
Suchanecka, Aleksandra
Masiak, Jolanta
Michałowska-Sawczyn, Monika
Boroń, Agnieszka
Cięszczyk, Paweł
Grzywacz, Anna
Epigenetic Analysis of the Dopamine Transporter Gene DAT1 with a Focus on Personality Traits in Athletes
title Epigenetic Analysis of the Dopamine Transporter Gene DAT1 with a Focus on Personality Traits in Athletes
title_full Epigenetic Analysis of the Dopamine Transporter Gene DAT1 with a Focus on Personality Traits in Athletes
title_fullStr Epigenetic Analysis of the Dopamine Transporter Gene DAT1 with a Focus on Personality Traits in Athletes
title_full_unstemmed Epigenetic Analysis of the Dopamine Transporter Gene DAT1 with a Focus on Personality Traits in Athletes
title_short Epigenetic Analysis of the Dopamine Transporter Gene DAT1 with a Focus on Personality Traits in Athletes
title_sort epigenetic analysis of the dopamine transporter gene dat1 with a focus on personality traits in athletes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218950/
https://www.ncbi.nlm.nih.gov/pubmed/37240274
http://dx.doi.org/10.3390/ijms24108931
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