Single-Dose Treatment with Rapamycin Preserves Post-Ischemic Cardiac Function through Attenuation of Fibrosis and Inflammation in Diabetic Rabbit

Robust activation of mTOR (mammalian target of rapamycin) signaling in diabetes exacerbates myocardial injury following lethal ischemia due to accelerated cardiomyocyte death with cardiac remodeling and inflammatory responses. We examined the effect of rapamycin (RAPA, mTOR inhibitor) on cardiac rem...

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Detalles Bibliográficos
Autores principales: Samidurai, Arun, Saravanan, Manu, Ockaili, Ramzi, Kraskauskas, Donatas, Lau, Suet Ying Valerie, Kodali, Varun, Ramasamy, Shakthi, Bhoopathi, Karthikeya, Nair, Megha, Roh, Sean K., Kukreja, Rakesh C., Das, Anindita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10218967/
https://www.ncbi.nlm.nih.gov/pubmed/37240345
http://dx.doi.org/10.3390/ijms24108998

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