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A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant

Current worldwide mRNA vaccination against SARS-CoV-2 by intramuscular injection using a needled syringe has greatly protected numerous people from COVID-19. An intramuscular injection is generally well tolerated, safer and easier to perform on a large scale, whereas the skin has the benefit of the...

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Autores principales: Sonoda, Jukito, Mizoguchi, Izuru, Inoue, Shinya, Watanabe, Aruma, Sekine, Ami, Yamagishi, Miu, Miyakawa, Satomi, Yamaguchi, Natsuki, Horio, Eri, Katahira, Yasuhiro, Hasegawa, Hideaki, Hasegawa, Takashi, Yamashita, Kunihiko, Yoshimoto, Takayuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219147/
https://www.ncbi.nlm.nih.gov/pubmed/37240448
http://dx.doi.org/10.3390/ijms24109094
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author Sonoda, Jukito
Mizoguchi, Izuru
Inoue, Shinya
Watanabe, Aruma
Sekine, Ami
Yamagishi, Miu
Miyakawa, Satomi
Yamaguchi, Natsuki
Horio, Eri
Katahira, Yasuhiro
Hasegawa, Hideaki
Hasegawa, Takashi
Yamashita, Kunihiko
Yoshimoto, Takayuki
author_facet Sonoda, Jukito
Mizoguchi, Izuru
Inoue, Shinya
Watanabe, Aruma
Sekine, Ami
Yamagishi, Miu
Miyakawa, Satomi
Yamaguchi, Natsuki
Horio, Eri
Katahira, Yasuhiro
Hasegawa, Hideaki
Hasegawa, Takashi
Yamashita, Kunihiko
Yoshimoto, Takayuki
author_sort Sonoda, Jukito
collection PubMed
description Current worldwide mRNA vaccination against SARS-CoV-2 by intramuscular injection using a needled syringe has greatly protected numerous people from COVID-19. An intramuscular injection is generally well tolerated, safer and easier to perform on a large scale, whereas the skin has the benefit of the presence of numerous immune cells, such as professional antigen-presenting dendritic cells. Therefore, intradermal injection is considered superior to intramuscular injection for the induction of protective immunity, but more proficiency is required for the injection. To improve these issues, several different types of more versatile jet injectors have been developed to deliver DNAs, proteins or drugs by high jet velocity through the skin without a needle. Among them, a new needle-free pyro-drive jet injector has a unique characteristic that utilizes gunpower as a mechanical driving force, in particular, bi-phasic pyrotechnics to provoke high jet velocity and consequently the wide dispersion of the injected DNA solution in the skin. A significant amount of evidence has revealed that it is highly effective as a vaccinating tool to induce potent protective cellular and humoral immunity against cancers and infectious diseases. This is presumably explained by the fact that shear stress generated by the high jet velocity facilitates the uptake of DNA in the cells and, consequently, its protein expression. The shear stress also possibly elicits danger signals which, together with the plasmid DNA, subsequently induces the activation of innate immunity including dendritic cell maturation, leading to the establishment of adaptive immunity. This review summarizes the recent advances in needle-free jet injectors to augment the cellular and humoral immunity by intradermal injection and the possible mechanism of action.
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spelling pubmed-102191472023-05-27 A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant Sonoda, Jukito Mizoguchi, Izuru Inoue, Shinya Watanabe, Aruma Sekine, Ami Yamagishi, Miu Miyakawa, Satomi Yamaguchi, Natsuki Horio, Eri Katahira, Yasuhiro Hasegawa, Hideaki Hasegawa, Takashi Yamashita, Kunihiko Yoshimoto, Takayuki Int J Mol Sci Review Current worldwide mRNA vaccination against SARS-CoV-2 by intramuscular injection using a needled syringe has greatly protected numerous people from COVID-19. An intramuscular injection is generally well tolerated, safer and easier to perform on a large scale, whereas the skin has the benefit of the presence of numerous immune cells, such as professional antigen-presenting dendritic cells. Therefore, intradermal injection is considered superior to intramuscular injection for the induction of protective immunity, but more proficiency is required for the injection. To improve these issues, several different types of more versatile jet injectors have been developed to deliver DNAs, proteins or drugs by high jet velocity through the skin without a needle. Among them, a new needle-free pyro-drive jet injector has a unique characteristic that utilizes gunpower as a mechanical driving force, in particular, bi-phasic pyrotechnics to provoke high jet velocity and consequently the wide dispersion of the injected DNA solution in the skin. A significant amount of evidence has revealed that it is highly effective as a vaccinating tool to induce potent protective cellular and humoral immunity against cancers and infectious diseases. This is presumably explained by the fact that shear stress generated by the high jet velocity facilitates the uptake of DNA in the cells and, consequently, its protein expression. The shear stress also possibly elicits danger signals which, together with the plasmid DNA, subsequently induces the activation of innate immunity including dendritic cell maturation, leading to the establishment of adaptive immunity. This review summarizes the recent advances in needle-free jet injectors to augment the cellular and humoral immunity by intradermal injection and the possible mechanism of action. MDPI 2023-05-22 /pmc/articles/PMC10219147/ /pubmed/37240448 http://dx.doi.org/10.3390/ijms24109094 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sonoda, Jukito
Mizoguchi, Izuru
Inoue, Shinya
Watanabe, Aruma
Sekine, Ami
Yamagishi, Miu
Miyakawa, Satomi
Yamaguchi, Natsuki
Horio, Eri
Katahira, Yasuhiro
Hasegawa, Hideaki
Hasegawa, Takashi
Yamashita, Kunihiko
Yoshimoto, Takayuki
A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant
title A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant
title_full A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant
title_fullStr A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant
title_full_unstemmed A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant
title_short A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant
title_sort promising needle-free pyro-drive jet injector for augmentation of immunity by intradermal injection as a physical adjuvant
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219147/
https://www.ncbi.nlm.nih.gov/pubmed/37240448
http://dx.doi.org/10.3390/ijms24109094
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