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Diabetes Mellitus in Patients Undergoing Mitral Transcatheter Edge-to-Edge Repair—A Decade Experience in 1000+ Patients
Background: Diabetes mellitus worsens outcomes in patients suffering from heart disease undergoing cardiac procedures. Objectives: To investigate the impact of diabetes in patients undergoing mitral transcatheter edge-to-edge repair (M-TEER). Methods: 1118 patients treated with M-TEER for functional...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219195/ https://www.ncbi.nlm.nih.gov/pubmed/37240610 http://dx.doi.org/10.3390/jcm12103502 |
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author | Paukovitsch, Michael Felbel, Dominik Groeger, Matthias Rottbauer, Wolfgang Markovic, Sinisa Tadic, Marijana Schneider, Leonhard Moritz Keßler, Mirjam |
author_facet | Paukovitsch, Michael Felbel, Dominik Groeger, Matthias Rottbauer, Wolfgang Markovic, Sinisa Tadic, Marijana Schneider, Leonhard Moritz Keßler, Mirjam |
author_sort | Paukovitsch, Michael |
collection | PubMed |
description | Background: Diabetes mellitus worsens outcomes in patients suffering from heart disease undergoing cardiac procedures. Objectives: To investigate the impact of diabetes in patients undergoing mitral transcatheter edge-to-edge repair (M-TEER). Methods: 1118 patients treated with M-TEER for functional (FMR) and degenerative (DMR) mitral regurgitation (MR) between 2010 and 2021 were analyzed using the combined endpoint of death/rehospitalization for heart failure (HFH). Results: Among diabetics (N = 306; 27.4%), comorbidities such as coronary artery disease (75.2% vs. 62.7%; p < 0.001) and progressed (stage III/IV) chronic kidney disease (79.5% vs. 72.6%; p = 0.018) were more frequent. The rate of FMR was higher in diabetics (71.9% vs. 64.5%; p < 0.001). The combined endpoint occurred more frequently in diabetics (40.2% vs. 35.6%; log-rank = 0.035). While no difference was observed in FMR patients (36.8% vs. 37.6%; log-rank p = 0.710), rates of the combined endpoint differed significantly between diabetics and non-diabetics in DMR patients (48.8% vs. 31.9%; log-rank p = 0.001) only. However, diabetes did neither predict the combined endpoint in the overall (OR: 0.97; 95% CI 0.65–1.45; p = 0.890) nor in the DMR cohort (OR: 0.73; 95% CI 0.35–1.51; p = 0.389). Among diabetics treated with M-TEER, troponin (OR: 2.32; 95% CI 1.3–3.7; p = 0.002) and estimated glomerular filtration rate (OR: 0.52; 95% CI 0.3–0.88; p = 0.018) independently predicted the combined endpoint. Conclusions: Diabetes is associated with adverse outcomes after M-TEER, particularly in DMR patients. However, diabetes does not predict the combined endpoint. In diabetics undergoing M-TEER, biochemical markers associated with organ function and damage independently predict the combined endpoint of death and rehospitalization. |
format | Online Article Text |
id | pubmed-10219195 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102191952023-05-27 Diabetes Mellitus in Patients Undergoing Mitral Transcatheter Edge-to-Edge Repair—A Decade Experience in 1000+ Patients Paukovitsch, Michael Felbel, Dominik Groeger, Matthias Rottbauer, Wolfgang Markovic, Sinisa Tadic, Marijana Schneider, Leonhard Moritz Keßler, Mirjam J Clin Med Article Background: Diabetes mellitus worsens outcomes in patients suffering from heart disease undergoing cardiac procedures. Objectives: To investigate the impact of diabetes in patients undergoing mitral transcatheter edge-to-edge repair (M-TEER). Methods: 1118 patients treated with M-TEER for functional (FMR) and degenerative (DMR) mitral regurgitation (MR) between 2010 and 2021 were analyzed using the combined endpoint of death/rehospitalization for heart failure (HFH). Results: Among diabetics (N = 306; 27.4%), comorbidities such as coronary artery disease (75.2% vs. 62.7%; p < 0.001) and progressed (stage III/IV) chronic kidney disease (79.5% vs. 72.6%; p = 0.018) were more frequent. The rate of FMR was higher in diabetics (71.9% vs. 64.5%; p < 0.001). The combined endpoint occurred more frequently in diabetics (40.2% vs. 35.6%; log-rank = 0.035). While no difference was observed in FMR patients (36.8% vs. 37.6%; log-rank p = 0.710), rates of the combined endpoint differed significantly between diabetics and non-diabetics in DMR patients (48.8% vs. 31.9%; log-rank p = 0.001) only. However, diabetes did neither predict the combined endpoint in the overall (OR: 0.97; 95% CI 0.65–1.45; p = 0.890) nor in the DMR cohort (OR: 0.73; 95% CI 0.35–1.51; p = 0.389). Among diabetics treated with M-TEER, troponin (OR: 2.32; 95% CI 1.3–3.7; p = 0.002) and estimated glomerular filtration rate (OR: 0.52; 95% CI 0.3–0.88; p = 0.018) independently predicted the combined endpoint. Conclusions: Diabetes is associated with adverse outcomes after M-TEER, particularly in DMR patients. However, diabetes does not predict the combined endpoint. In diabetics undergoing M-TEER, biochemical markers associated with organ function and damage independently predict the combined endpoint of death and rehospitalization. MDPI 2023-05-16 /pmc/articles/PMC10219195/ /pubmed/37240610 http://dx.doi.org/10.3390/jcm12103502 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Paukovitsch, Michael Felbel, Dominik Groeger, Matthias Rottbauer, Wolfgang Markovic, Sinisa Tadic, Marijana Schneider, Leonhard Moritz Keßler, Mirjam Diabetes Mellitus in Patients Undergoing Mitral Transcatheter Edge-to-Edge Repair—A Decade Experience in 1000+ Patients |
title | Diabetes Mellitus in Patients Undergoing Mitral Transcatheter Edge-to-Edge Repair—A Decade Experience in 1000+ Patients |
title_full | Diabetes Mellitus in Patients Undergoing Mitral Transcatheter Edge-to-Edge Repair—A Decade Experience in 1000+ Patients |
title_fullStr | Diabetes Mellitus in Patients Undergoing Mitral Transcatheter Edge-to-Edge Repair—A Decade Experience in 1000+ Patients |
title_full_unstemmed | Diabetes Mellitus in Patients Undergoing Mitral Transcatheter Edge-to-Edge Repair—A Decade Experience in 1000+ Patients |
title_short | Diabetes Mellitus in Patients Undergoing Mitral Transcatheter Edge-to-Edge Repair—A Decade Experience in 1000+ Patients |
title_sort | diabetes mellitus in patients undergoing mitral transcatheter edge-to-edge repair—a decade experience in 1000+ patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219195/ https://www.ncbi.nlm.nih.gov/pubmed/37240610 http://dx.doi.org/10.3390/jcm12103502 |
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