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Do Patients with Diabetes Mellitus and Polytrauma Continue to Have Worse Outcomes?

The management of patients with multiple injuries remains challenging. Patients presenting with comorbidities, such as diabetes mellitus, may have additional unpredictable outcomes with increased mortality. Therefore, we aim to investigate the impact of major trauma centres in the UK on the outcomes...

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Autores principales: Tebby, James, Giannoudis, Vasileios P., Wakefield, Sophia M., Lecky, Fiona, Bouamra, Omar, Giannoudis, Peter V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219204/
https://www.ncbi.nlm.nih.gov/pubmed/37240529
http://dx.doi.org/10.3390/jcm12103423
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author Tebby, James
Giannoudis, Vasileios P.
Wakefield, Sophia M.
Lecky, Fiona
Bouamra, Omar
Giannoudis, Peter V.
author_facet Tebby, James
Giannoudis, Vasileios P.
Wakefield, Sophia M.
Lecky, Fiona
Bouamra, Omar
Giannoudis, Peter V.
author_sort Tebby, James
collection PubMed
description The management of patients with multiple injuries remains challenging. Patients presenting with comorbidities, such as diabetes mellitus, may have additional unpredictable outcomes with increased mortality. Therefore, we aim to investigate the impact of major trauma centres in the UK on the outcomes of polytrauma patients with diabetes. The Trauma Audit and Research Network was used to identify polytrauma patients presenting to centres in England and Wales between 2012 and 2019. In total, 32,345 patients were thereby included and divided into three groups: 2271 with diabetes, 16,319 with comorbidities other than diabetes and 13,755 who had no comorbidities. Despite an overall increase in diabetic prevalence compared to previously published data, mortality was reduced in all groups, but diabetic patient mortality remained higher than in the other groups. Interestingly, increasing Injury Severity Score (ISS) and age were associated with increasing mortality, whereas the presence of diabetes, even when taking into consideration age, ISS and Glasgow Coma Score, led to an increase in the prediction of mortality with an odds ratio of 1.36 (p < 0.0001). The prevalence of diabetes mellitus in polytrauma patients has increased, and diabetes remains an independent risk factor for mortality following polytrauma.
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spelling pubmed-102192042023-05-27 Do Patients with Diabetes Mellitus and Polytrauma Continue to Have Worse Outcomes? Tebby, James Giannoudis, Vasileios P. Wakefield, Sophia M. Lecky, Fiona Bouamra, Omar Giannoudis, Peter V. J Clin Med Article The management of patients with multiple injuries remains challenging. Patients presenting with comorbidities, such as diabetes mellitus, may have additional unpredictable outcomes with increased mortality. Therefore, we aim to investigate the impact of major trauma centres in the UK on the outcomes of polytrauma patients with diabetes. The Trauma Audit and Research Network was used to identify polytrauma patients presenting to centres in England and Wales between 2012 and 2019. In total, 32,345 patients were thereby included and divided into three groups: 2271 with diabetes, 16,319 with comorbidities other than diabetes and 13,755 who had no comorbidities. Despite an overall increase in diabetic prevalence compared to previously published data, mortality was reduced in all groups, but diabetic patient mortality remained higher than in the other groups. Interestingly, increasing Injury Severity Score (ISS) and age were associated with increasing mortality, whereas the presence of diabetes, even when taking into consideration age, ISS and Glasgow Coma Score, led to an increase in the prediction of mortality with an odds ratio of 1.36 (p < 0.0001). The prevalence of diabetes mellitus in polytrauma patients has increased, and diabetes remains an independent risk factor for mortality following polytrauma. MDPI 2023-05-12 /pmc/articles/PMC10219204/ /pubmed/37240529 http://dx.doi.org/10.3390/jcm12103423 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tebby, James
Giannoudis, Vasileios P.
Wakefield, Sophia M.
Lecky, Fiona
Bouamra, Omar
Giannoudis, Peter V.
Do Patients with Diabetes Mellitus and Polytrauma Continue to Have Worse Outcomes?
title Do Patients with Diabetes Mellitus and Polytrauma Continue to Have Worse Outcomes?
title_full Do Patients with Diabetes Mellitus and Polytrauma Continue to Have Worse Outcomes?
title_fullStr Do Patients with Diabetes Mellitus and Polytrauma Continue to Have Worse Outcomes?
title_full_unstemmed Do Patients with Diabetes Mellitus and Polytrauma Continue to Have Worse Outcomes?
title_short Do Patients with Diabetes Mellitus and Polytrauma Continue to Have Worse Outcomes?
title_sort do patients with diabetes mellitus and polytrauma continue to have worse outcomes?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219204/
https://www.ncbi.nlm.nih.gov/pubmed/37240529
http://dx.doi.org/10.3390/jcm12103423
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