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Transfusion Burden in Allogeneic Hematopoietic Stem Cell Transplantation over Time: Experience from a Single Institution

Introduction: Transfusion plays a main role in supportive treatment for patients who receive an allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we compare the transfusion requirements of patients undergoing different modalities of HSCT according to different time periods. T...

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Autores principales: Solves, Pilar, Marco-Ayala, Javier, Sanz, Miguel Ángel, Gómez-Seguí, Inés, Balaguer-Roselló, Aitana, Facal, Ana, Villalba, Marta, Montoro, Juan, Sanz, Guillermo, de la Rubia, Javier, Sanz, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219209/
https://www.ncbi.nlm.nih.gov/pubmed/37240573
http://dx.doi.org/10.3390/jcm12103467
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author Solves, Pilar
Marco-Ayala, Javier
Sanz, Miguel Ángel
Gómez-Seguí, Inés
Balaguer-Roselló, Aitana
Facal, Ana
Villalba, Marta
Montoro, Juan
Sanz, Guillermo
de la Rubia, Javier
Sanz, Jaime
author_facet Solves, Pilar
Marco-Ayala, Javier
Sanz, Miguel Ángel
Gómez-Seguí, Inés
Balaguer-Roselló, Aitana
Facal, Ana
Villalba, Marta
Montoro, Juan
Sanz, Guillermo
de la Rubia, Javier
Sanz, Jaime
author_sort Solves, Pilar
collection PubMed
description Introduction: Transfusion plays a main role in supportive treatment for patients who receive an allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we compare the transfusion requirements of patients undergoing different modalities of HSCT according to different time periods. The objective is to assess the evolution of HSCT transfusion requirements over time, from a single institution. Methods: The clinical charts and transfusion records of patients who underwent HSCT of different modalities at La Fe University Hospital during a twelve-year period were reviewed (2009–2020). For analysis, we divided the overall time into three periods: 1 from 2009 to 2012, 2 from 2013 to 2016 and 3 from 2017 to 2020. The study included 855 consecutive adult HSCT: 358 HLA-matched related donors (MRD), 134 HLA-matched unrelated donors (MUD), 223 umbilical cord blood transplantation (UCBT) and 140 haploidentical transplants (Haplo-HSCT). Results: There were no significant differences in RBC and PLT requirements or transfusion independence among the three time periods for MUD and Haplo-HSCT. However, the transfusion burden increased significantly for MRD HSCT during the 2017–2020 period. Conclusion: despite HSCT modalities having evolved and changed over time, overall transfusion requirements have not significantly decreased and continue to be a cornerstone of transplantation-supportive care.
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spelling pubmed-102192092023-05-27 Transfusion Burden in Allogeneic Hematopoietic Stem Cell Transplantation over Time: Experience from a Single Institution Solves, Pilar Marco-Ayala, Javier Sanz, Miguel Ángel Gómez-Seguí, Inés Balaguer-Roselló, Aitana Facal, Ana Villalba, Marta Montoro, Juan Sanz, Guillermo de la Rubia, Javier Sanz, Jaime J Clin Med Article Introduction: Transfusion plays a main role in supportive treatment for patients who receive an allogeneic hematopoietic stem cell transplantation (HSCT). In this study, we compare the transfusion requirements of patients undergoing different modalities of HSCT according to different time periods. The objective is to assess the evolution of HSCT transfusion requirements over time, from a single institution. Methods: The clinical charts and transfusion records of patients who underwent HSCT of different modalities at La Fe University Hospital during a twelve-year period were reviewed (2009–2020). For analysis, we divided the overall time into three periods: 1 from 2009 to 2012, 2 from 2013 to 2016 and 3 from 2017 to 2020. The study included 855 consecutive adult HSCT: 358 HLA-matched related donors (MRD), 134 HLA-matched unrelated donors (MUD), 223 umbilical cord blood transplantation (UCBT) and 140 haploidentical transplants (Haplo-HSCT). Results: There were no significant differences in RBC and PLT requirements or transfusion independence among the three time periods for MUD and Haplo-HSCT. However, the transfusion burden increased significantly for MRD HSCT during the 2017–2020 period. Conclusion: despite HSCT modalities having evolved and changed over time, overall transfusion requirements have not significantly decreased and continue to be a cornerstone of transplantation-supportive care. MDPI 2023-05-15 /pmc/articles/PMC10219209/ /pubmed/37240573 http://dx.doi.org/10.3390/jcm12103467 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Solves, Pilar
Marco-Ayala, Javier
Sanz, Miguel Ángel
Gómez-Seguí, Inés
Balaguer-Roselló, Aitana
Facal, Ana
Villalba, Marta
Montoro, Juan
Sanz, Guillermo
de la Rubia, Javier
Sanz, Jaime
Transfusion Burden in Allogeneic Hematopoietic Stem Cell Transplantation over Time: Experience from a Single Institution
title Transfusion Burden in Allogeneic Hematopoietic Stem Cell Transplantation over Time: Experience from a Single Institution
title_full Transfusion Burden in Allogeneic Hematopoietic Stem Cell Transplantation over Time: Experience from a Single Institution
title_fullStr Transfusion Burden in Allogeneic Hematopoietic Stem Cell Transplantation over Time: Experience from a Single Institution
title_full_unstemmed Transfusion Burden in Allogeneic Hematopoietic Stem Cell Transplantation over Time: Experience from a Single Institution
title_short Transfusion Burden in Allogeneic Hematopoietic Stem Cell Transplantation over Time: Experience from a Single Institution
title_sort transfusion burden in allogeneic hematopoietic stem cell transplantation over time: experience from a single institution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219209/
https://www.ncbi.nlm.nih.gov/pubmed/37240573
http://dx.doi.org/10.3390/jcm12103467
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