Cargando…

Dynamic polarization of tumor-associated macrophages and their interaction with intratumoral T cells in an inflamed tumor microenvironment: from mechanistic insights to therapeutic opportunities

Immunotherapy has brought a paradigm shift in the treatment of tumors in recent decades. However, a significant proportion of patients remain unresponsive, largely due to the immunosuppressive tumor microenvironment (TME). Tumor-associated macrophages (TAMs) play crucial roles in shaping the TME by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Jiashu, Dong, Luochu, Wu, Mengwei, Ma, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2023
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219223/ https://www.ncbi.nlm.nih.gov/pubmed/37251409 http://dx.doi.org/10.3389/fimmu.2023.1160340

Ejemplares similares

Metabolic Reprogramming Induces Macrophage Polarization in the Tumor Microenvironment
por: Wang, Shilin, et al.
Publicado: (2022)

Uncoding the interdependency of tumor microenvironment and macrophage polarization: insights from a continuous network approach
por: Avila-Ponce de León, Ugo, et al.
Publicado: (2023)

Tumor-associated microglia and macrophages in glioblastoma: From basic insights to therapeutic opportunities
por: Wang, Guoqing, et al.
Publicado: (2022)

Proteasome-dependent senescent tumor cells mediate immunosuppression through CCL20 secretion and M2 polarization in pancreatic ductal adenocarcinoma
por: Wu, Mengwei, et al.
Publicado: (2023)

Interferon-Induced Transmembrane Protein 3 Shapes an Inflamed Tumor Microenvironment and Identifies Immuno-Hot Tumors
por: Cai, Yun, et al.
Publicado: (2021)

Intratumor microbiota in cancer pathogenesis and immunity: from mechanisms of action to therapeutic opportunities
por: Wang, Man, et al.
Publicado: (2023)

Dysregulation in IFN-γ signaling and response: the barricade to tumor immunotherapy
por: Han, Jiashu, et al.
Publicado: (2023)

EZH2 Inhibitors Suppress Colorectal Cancer by Regulating Macrophage Polarization in the Tumor Microenvironment
por: Li, Chen, et al.
Publicado: (2022)

Senescence Inflames the Pancreatic Tumor Microenvironment
por: Petroni, Giulia, et al.
Publicado: (2020)

Lung Tumor Microenvironment Induces Specific Gene Expression Signature in Intratumoral NK Cells
por: Gillard-Bocquet, Mélanie, et al.
Publicado: (2013)

Recruitment mechanisms and therapeutic implications of tumor-associated macrophages in the glioma microenvironment
por: Zhou, Xianzhe, et al.
Publicado: (2023)

Cutting edges and therapeutic opportunities on tumor-associated macrophages in lung cancer
por: Hu, Qin, et al.
Publicado: (2022)

The G2A Receptor Controls Polarization of Macrophage by Determining Their Localization Within the Inflamed Tissue
por: Kern, Katharina, et al.
Publicado: (2018)

Tumor-associated macrophages: an effective player of the tumor microenvironment
por: Basak, Udit, et al.
Publicado: (2023)

Dendritic Cell Vaccination in Metastatic Melanoma Turns “Non-T Cell Inflamed” Into “T-Cell Inflamed” Tumors
por: Bulgarelli, Jenny, et al.
Publicado: (2019)

Systemic Inflammation Associates With a Myeloid Inflamed Tumor Microenvironment in Primary Resected Colon Cancer—May Cold Tumors Simply Be Too Hot?
por: Køstner, Anne Helene, et al.
Publicado: (2021)

Plasma Cells in the Melanoma Tumor Microenvironment—Mechanistic Roles for IgA
por: Verma, Rakesh, et al.
Publicado: (2020)

Redefining Tumor-Associated Macrophage Subpopulations and Functions in the Tumor Microenvironment
por: Wu, Kaiyue, et al.
Publicado: (2020)

Tumor-Associated Macrophages and Their Functional Transformation in the Hypoxic Tumor Microenvironment
por: He, Zicong, et al.
Publicado: (2021)

Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity
por: Janji, Bassam, et al.
Publicado: (2018)

Macrophage Polarization States in the Tumor Microenvironment
por: Boutilier, Ava J., et al.
Publicado: (2021)

Wnt Signaling and Its Significance Within the Tumor Microenvironment: Novel Therapeutic Insights
por: Patel, Sonal, et al.
Publicado: (2019)

Chamaejasmenin B, an Inhibitor for Metastatic Outgrowth, Reversed M2-Dominant Macrophage Polarization in Breast Tumor Microenvironment
por: Li, Qi, et al.
Publicado: (2021)

Tumor−associated macrophage polarization in the inflammatory tumor microenvironment
por: Zou, Zijuan, et al.
Publicado: (2023)

Myeloid Cell Classification and Therapeutic Opportunities Within the Glioblastoma Tumor Microenvironment in the Single Cell-Omics Era
por: Larkin, Collin J., et al.
Publicado: (2022)

Role of tumor microenvironment in the pathobiology of ovarian cancer: Insights and therapeutic opportunities
por: Ghoneum, Alia, et al.
Publicado: (2018)

Intratumoral CD73: An immune checkpoint shaping an inhibitory tumor microenvironment and implicating poor prognosis in Chinese melanoma cohorts
por: Gao, Zixu, et al.
Publicado: (2022)

Shaping Polarization Of Tumor-Associated Macrophages In Cancer Immunotherapy
por: Gao, Jing, et al.
Publicado: (2022)

Updates on immunological mechanistic insights and targeting of the oral lichen planus microenvironment
por: Deng, Xiaoting, et al.
Publicado: (2023)

Boolean modeling reveals that cyclic attractors in macrophage polarization serve as reservoirs of states to balance external perturbations from the tumor microenvironment
por: de León, Ugo Avila-Ponce, et al.
Publicado: (2022)

Resveratrol and Tumor Microenvironment: Mechanistic Basis and Therapeutic Targets
por: Talib, Wamidh H., et al.
Publicado: (2020)

Loss of NLRP3 reduces oxidative stress and polarizes intratumor macrophages to attenuate immune attack on endometrial cancer
por: Zhu, Xiaolu, et al.
Publicado: (2023)

Escherichia coli adhesion portion FimH polarizes M2 macrophages to M1 macrophages in tumor microenvironment via toll-like receptor 4
por: Zhang, Wei, et al.
Publicado: (2023)

The extracellular vesicles targeting tumor microenvironment: a promising therapeutic strategy for melanoma
por: Li, Yongmin, et al.
Publicado: (2023)

The genetic landscape of the T cell non-inflamed tumor microenvironment in human solid tumors
por: Luke, Jason J, et al.
Publicado: (2015)

Lysine-Specific Histone Demethylase 1A Regulates Macrophage Polarization and Checkpoint Molecules in the Tumor Microenvironment of Triple-Negative Breast Cancer
por: Tan, Abel H. Y., et al.
Publicado: (2019)

Specialized Pro-Resolving Mediators Mitigate Cancer-Related Inflammation: Role of Tumor-Associated Macrophages and Therapeutic Opportunities
por: Lavy, Margot, et al.
Publicado: (2021)

Bacteriostatic Potential of Melatonin: Therapeutic Standing and Mechanistic Insights
por: He, Fang, et al.
Publicado: (2021)

The Tumor Microenvironment in SCC: Mechanisms and Therapeutic Opportunities
por: Amôr, Nádia Ghinelli, et al.
Publicado: (2021)

Biological Effects of Nanoparticles on Macrophage Polarization in the Tumor Microenvironment
por: Reichel, Derek, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_d7b2r66m617jsvk2rej6ktse03