Cargando…

COVID-19-Associated Disease Course Is Shortened in Moderate-to-Severe Atopic Dermatitis Patients Receiving Dupilumab Treatment: A Retrospective Cross-Sectional Study

Previous studies suggest that allergic diseases may be a protective factor in SARS-CoV-2 infection. However, data regarding the impact of dupilumab, a widely used immunomodulatory medication, on COVID-19 in an allergic population are very limited. To investigate the incidence and severity of COVID-1...

Descripción completa

Detalles Bibliográficos
Autores principales: Ma, Dongxia, Wang, Yin, Huang, Nan, Li, Wenjing, Chen, Hao, Yang, Yaqi, Zhu, Rongfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219280/
https://www.ncbi.nlm.nih.gov/pubmed/37240520
http://dx.doi.org/10.3390/jcm12103415
_version_ 1785048972483624960
author Ma, Dongxia
Wang, Yin
Huang, Nan
Li, Wenjing
Chen, Hao
Yang, Yaqi
Zhu, Rongfei
author_facet Ma, Dongxia
Wang, Yin
Huang, Nan
Li, Wenjing
Chen, Hao
Yang, Yaqi
Zhu, Rongfei
author_sort Ma, Dongxia
collection PubMed
description Previous studies suggest that allergic diseases may be a protective factor in SARS-CoV-2 infection. However, data regarding the impact of dupilumab, a widely used immunomodulatory medication, on COVID-19 in an allergic population are very limited. To investigate the incidence and severity of COVID-19 among moderate-to-severe atopic dermatitis (AD) patients treated with dupilumab, a retrospective cross-sectional survey was conducted among patients with moderate-to-severe AD who presented at the Department of Allergy of Tongji Hospital from 15 January 2023 to 31 January 2023. Healthy individuals matched for gender and age were also enrolled as a control. All subjects were asked about their demographic characteristics, past medical history, COVID-19 vaccination history, and medications, as well as the presence and duration of individual COVID-19-related symptoms. A total of 159 moderate-to-severe AD patients and 198 healthy individuals were enrolled in the study. Among the AD patients, 97 patients were treated with dupilumab, and 62 patients did not receive any biologicals or systemic treatments (topical treatment group). The proportions of people who were not infected with COVID in the dupilumab treatment group, topical treatment group and healthy control group were 10.31%, 9.68% and 19.19%, respectively (p = 0.057). There was no significant difference in COVID-19-related symptom scores among all groups (p = 0.059). The hospitalization rates were 3.58% in the topical treatment group and 1.25% in the healthy control group, and no patient was hospitalized in the dupilumab treatment group (p = 0.163). Compared with healthy control group and topical treatment group, the dupilumab treatment group had the shortest COVID-19-associated disease duration (dupilumab treatment group, 4.15 ± 2.85 d vs. topical treatment group, 5.43 ± 3.15 d vs. healthy control group, 6.09 ± 4.29 d; p = 0.001). Among the AD patients treated with dupilumab for different times, there was no appreciable difference (<0.5 year group, 5 ± 3.62 d vs. 0.5–1 year group, 4.84 ± 2.58 d vs. >1 year group, 2.8 ± 1.32 d; p = 0.183). Dupilumab treatment shortened the duration of COVID-19 in patients with moderate-to-severe AD. AD patients can continue their dupilumab treatment during the COVID-19 pandemic.
format Online
Article
Text
id pubmed-10219280
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102192802023-05-27 COVID-19-Associated Disease Course Is Shortened in Moderate-to-Severe Atopic Dermatitis Patients Receiving Dupilumab Treatment: A Retrospective Cross-Sectional Study Ma, Dongxia Wang, Yin Huang, Nan Li, Wenjing Chen, Hao Yang, Yaqi Zhu, Rongfei J Clin Med Article Previous studies suggest that allergic diseases may be a protective factor in SARS-CoV-2 infection. However, data regarding the impact of dupilumab, a widely used immunomodulatory medication, on COVID-19 in an allergic population are very limited. To investigate the incidence and severity of COVID-19 among moderate-to-severe atopic dermatitis (AD) patients treated with dupilumab, a retrospective cross-sectional survey was conducted among patients with moderate-to-severe AD who presented at the Department of Allergy of Tongji Hospital from 15 January 2023 to 31 January 2023. Healthy individuals matched for gender and age were also enrolled as a control. All subjects were asked about their demographic characteristics, past medical history, COVID-19 vaccination history, and medications, as well as the presence and duration of individual COVID-19-related symptoms. A total of 159 moderate-to-severe AD patients and 198 healthy individuals were enrolled in the study. Among the AD patients, 97 patients were treated with dupilumab, and 62 patients did not receive any biologicals or systemic treatments (topical treatment group). The proportions of people who were not infected with COVID in the dupilumab treatment group, topical treatment group and healthy control group were 10.31%, 9.68% and 19.19%, respectively (p = 0.057). There was no significant difference in COVID-19-related symptom scores among all groups (p = 0.059). The hospitalization rates were 3.58% in the topical treatment group and 1.25% in the healthy control group, and no patient was hospitalized in the dupilumab treatment group (p = 0.163). Compared with healthy control group and topical treatment group, the dupilumab treatment group had the shortest COVID-19-associated disease duration (dupilumab treatment group, 4.15 ± 2.85 d vs. topical treatment group, 5.43 ± 3.15 d vs. healthy control group, 6.09 ± 4.29 d; p = 0.001). Among the AD patients treated with dupilumab for different times, there was no appreciable difference (<0.5 year group, 5 ± 3.62 d vs. 0.5–1 year group, 4.84 ± 2.58 d vs. >1 year group, 2.8 ± 1.32 d; p = 0.183). Dupilumab treatment shortened the duration of COVID-19 in patients with moderate-to-severe AD. AD patients can continue their dupilumab treatment during the COVID-19 pandemic. MDPI 2023-05-11 /pmc/articles/PMC10219280/ /pubmed/37240520 http://dx.doi.org/10.3390/jcm12103415 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ma, Dongxia
Wang, Yin
Huang, Nan
Li, Wenjing
Chen, Hao
Yang, Yaqi
Zhu, Rongfei
COVID-19-Associated Disease Course Is Shortened in Moderate-to-Severe Atopic Dermatitis Patients Receiving Dupilumab Treatment: A Retrospective Cross-Sectional Study
title COVID-19-Associated Disease Course Is Shortened in Moderate-to-Severe Atopic Dermatitis Patients Receiving Dupilumab Treatment: A Retrospective Cross-Sectional Study
title_full COVID-19-Associated Disease Course Is Shortened in Moderate-to-Severe Atopic Dermatitis Patients Receiving Dupilumab Treatment: A Retrospective Cross-Sectional Study
title_fullStr COVID-19-Associated Disease Course Is Shortened in Moderate-to-Severe Atopic Dermatitis Patients Receiving Dupilumab Treatment: A Retrospective Cross-Sectional Study
title_full_unstemmed COVID-19-Associated Disease Course Is Shortened in Moderate-to-Severe Atopic Dermatitis Patients Receiving Dupilumab Treatment: A Retrospective Cross-Sectional Study
title_short COVID-19-Associated Disease Course Is Shortened in Moderate-to-Severe Atopic Dermatitis Patients Receiving Dupilumab Treatment: A Retrospective Cross-Sectional Study
title_sort covid-19-associated disease course is shortened in moderate-to-severe atopic dermatitis patients receiving dupilumab treatment: a retrospective cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219280/
https://www.ncbi.nlm.nih.gov/pubmed/37240520
http://dx.doi.org/10.3390/jcm12103415
work_keys_str_mv AT madongxia covid19associateddiseasecourseisshortenedinmoderatetosevereatopicdermatitispatientsreceivingdupilumabtreatmentaretrospectivecrosssectionalstudy
AT wangyin covid19associateddiseasecourseisshortenedinmoderatetosevereatopicdermatitispatientsreceivingdupilumabtreatmentaretrospectivecrosssectionalstudy
AT huangnan covid19associateddiseasecourseisshortenedinmoderatetosevereatopicdermatitispatientsreceivingdupilumabtreatmentaretrospectivecrosssectionalstudy
AT liwenjing covid19associateddiseasecourseisshortenedinmoderatetosevereatopicdermatitispatientsreceivingdupilumabtreatmentaretrospectivecrosssectionalstudy
AT chenhao covid19associateddiseasecourseisshortenedinmoderatetosevereatopicdermatitispatientsreceivingdupilumabtreatmentaretrospectivecrosssectionalstudy
AT yangyaqi covid19associateddiseasecourseisshortenedinmoderatetosevereatopicdermatitispatientsreceivingdupilumabtreatmentaretrospectivecrosssectionalstudy
AT zhurongfei covid19associateddiseasecourseisshortenedinmoderatetosevereatopicdermatitispatientsreceivingdupilumabtreatmentaretrospectivecrosssectionalstudy