Cargando…
Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician’s Perspective
The endemic fungal infection, coccidioidomycosis, occurs after inhalation of one or very few Coccidioides spp. spores. Infections produce diverse clinical manifestations, ranging from insignificant to extremely destructive, even fatal. Approaches to understanding this range of consequences have trad...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219288/ https://www.ncbi.nlm.nih.gov/pubmed/37233265 http://dx.doi.org/10.3390/jof9050554 |
_version_ | 1785048974392033280 |
---|---|
author | Galgiani, John N. Hsu, Amy P. Powell, Daniel A. Vyas, Jatin M. Holland, Steven M. |
author_facet | Galgiani, John N. Hsu, Amy P. Powell, Daniel A. Vyas, Jatin M. Holland, Steven M. |
author_sort | Galgiani, John N. |
collection | PubMed |
description | The endemic fungal infection, coccidioidomycosis, occurs after inhalation of one or very few Coccidioides spp. spores. Infections produce diverse clinical manifestations, ranging from insignificant to extremely destructive, even fatal. Approaches to understanding this range of consequences have traditionally categorized patients into a small number of groups (asymptomatic, uncomplicated self-limited, fibro-cavitary, and extra-thoracic disseminated) and then looked for immunologic differences among them. Recently, variants within genes of innate pathways have been found to account, in part, for infections that result in disseminated disease. This discovery raises the very attractive theory that, in patients without severe immunosuppression, much of the disease spectrum can be accounted for by various combinations of such deleterious variants in innate pathways. In this review, we summarize what is known about genetic determinants that are responsible for the severity of coccidioidal infections and how complex innate genetic differences among different people might account for the spectrum of disease observed clinically. |
format | Online Article Text |
id | pubmed-10219288 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102192882023-05-27 Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician’s Perspective Galgiani, John N. Hsu, Amy P. Powell, Daniel A. Vyas, Jatin M. Holland, Steven M. J Fungi (Basel) Review The endemic fungal infection, coccidioidomycosis, occurs after inhalation of one or very few Coccidioides spp. spores. Infections produce diverse clinical manifestations, ranging from insignificant to extremely destructive, even fatal. Approaches to understanding this range of consequences have traditionally categorized patients into a small number of groups (asymptomatic, uncomplicated self-limited, fibro-cavitary, and extra-thoracic disseminated) and then looked for immunologic differences among them. Recently, variants within genes of innate pathways have been found to account, in part, for infections that result in disseminated disease. This discovery raises the very attractive theory that, in patients without severe immunosuppression, much of the disease spectrum can be accounted for by various combinations of such deleterious variants in innate pathways. In this review, we summarize what is known about genetic determinants that are responsible for the severity of coccidioidal infections and how complex innate genetic differences among different people might account for the spectrum of disease observed clinically. MDPI 2023-05-11 /pmc/articles/PMC10219288/ /pubmed/37233265 http://dx.doi.org/10.3390/jof9050554 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Galgiani, John N. Hsu, Amy P. Powell, Daniel A. Vyas, Jatin M. Holland, Steven M. Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician’s Perspective |
title | Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician’s Perspective |
title_full | Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician’s Perspective |
title_fullStr | Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician’s Perspective |
title_full_unstemmed | Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician’s Perspective |
title_short | Genetic and Other Determinants for the Severity of Coccidioidomycosis: A Clinician’s Perspective |
title_sort | genetic and other determinants for the severity of coccidioidomycosis: a clinician’s perspective |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219288/ https://www.ncbi.nlm.nih.gov/pubmed/37233265 http://dx.doi.org/10.3390/jof9050554 |
work_keys_str_mv | AT galgianijohnn geneticandotherdeterminantsfortheseverityofcoccidioidomycosisacliniciansperspective AT hsuamyp geneticandotherdeterminantsfortheseverityofcoccidioidomycosisacliniciansperspective AT powelldaniela geneticandotherdeterminantsfortheseverityofcoccidioidomycosisacliniciansperspective AT vyasjatinm geneticandotherdeterminantsfortheseverityofcoccidioidomycosisacliniciansperspective AT hollandstevenm geneticandotherdeterminantsfortheseverityofcoccidioidomycosisacliniciansperspective |