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Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma

The molecular characterization of endometrial carcinoma (EC) has recently been included in the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice and the relevance of pathologic parameters in predicting...

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Autores principales: Ruscelli, Martina, Maloberti, Thais, Corradini, Angelo Gianluca, Rosini, Francesca, Querzoli, Giulia, Grillini, Marco, Altimari, Annalisa, Gruppioni, Elisa, Sanza, Viviana, Costantino, Alessia, Ciudino, Riccardo, Errani, Matteo, Papapietro, Alessia, Coluccelli, Sara, Turchetti, Daniela, Ferioli, Martina, Giunchi, Susanna, Dondi, Giulia, Tesei, Marco, Ravegnini, Gloria, Abbati, Francesca, Rubino, Daniela, Zamagni, Claudio, D’Angelo, Emanuela, De Iaco, Pierandrea, Santini, Donatella, Ceccarelli, Claudio, Perrone, Anna Myriam, Tallini, Giovanni, de Biase, Dario, De Leo, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219289/
https://www.ncbi.nlm.nih.gov/pubmed/37240893
http://dx.doi.org/10.3390/jpm13050723
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author Ruscelli, Martina
Maloberti, Thais
Corradini, Angelo Gianluca
Rosini, Francesca
Querzoli, Giulia
Grillini, Marco
Altimari, Annalisa
Gruppioni, Elisa
Sanza, Viviana
Costantino, Alessia
Ciudino, Riccardo
Errani, Matteo
Papapietro, Alessia
Coluccelli, Sara
Turchetti, Daniela
Ferioli, Martina
Giunchi, Susanna
Dondi, Giulia
Tesei, Marco
Ravegnini, Gloria
Abbati, Francesca
Rubino, Daniela
Zamagni, Claudio
D’Angelo, Emanuela
De Iaco, Pierandrea
Santini, Donatella
Ceccarelli, Claudio
Perrone, Anna Myriam
Tallini, Giovanni
de Biase, Dario
De Leo, Antonio
author_facet Ruscelli, Martina
Maloberti, Thais
Corradini, Angelo Gianluca
Rosini, Francesca
Querzoli, Giulia
Grillini, Marco
Altimari, Annalisa
Gruppioni, Elisa
Sanza, Viviana
Costantino, Alessia
Ciudino, Riccardo
Errani, Matteo
Papapietro, Alessia
Coluccelli, Sara
Turchetti, Daniela
Ferioli, Martina
Giunchi, Susanna
Dondi, Giulia
Tesei, Marco
Ravegnini, Gloria
Abbati, Francesca
Rubino, Daniela
Zamagni, Claudio
D’Angelo, Emanuela
De Iaco, Pierandrea
Santini, Donatella
Ceccarelli, Claudio
Perrone, Anna Myriam
Tallini, Giovanni
de Biase, Dario
De Leo, Antonio
author_sort Ruscelli, Martina
collection PubMed
description The molecular characterization of endometrial carcinoma (EC) has recently been included in the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice and the relevance of pathologic parameters in predicting prognosis in each EC molecular subgroup. ECs were classified using immunohistochemistry and next-generation sequencing into the four molecular classes: POLE mutant (POLE), mismatch repair deficient (MMRd), p53 mutant (p53abn), and no specific molecular profile (NSMP). According to the WHO algorithm, 219 ECs were subdivided into the following molecular subgroups: 7.8% POLE, 31% MMRd, 21% p53abn, 40.2% NSMP. Molecular classes as well as ESGO/ESTRO/ESP 2020 risk groups were statistically correlated with disease-free survival. Considering the impact of histopathologic features in each molecular class, stage was found to be the strongest prognostic factor in MMRd ECs, whereas in the p53abn subgroup, only lymph node status was associated with recurrent disease. Interestingly, in the NSMP tumor, several histopathologic features were correlated with recurrence: histotype, grade, stage, tumor necrosis, and substantial lymphovascular space invasion. Considering early-stage NSMP ECs, substantial lymphovascular space invasion was the only independent prognostic factor. Our study supports the prognostic importance of EC molecular classification and demonstrated the essential role of histopathologic assessment in patients’ management.
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spelling pubmed-102192892023-05-27 Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma Ruscelli, Martina Maloberti, Thais Corradini, Angelo Gianluca Rosini, Francesca Querzoli, Giulia Grillini, Marco Altimari, Annalisa Gruppioni, Elisa Sanza, Viviana Costantino, Alessia Ciudino, Riccardo Errani, Matteo Papapietro, Alessia Coluccelli, Sara Turchetti, Daniela Ferioli, Martina Giunchi, Susanna Dondi, Giulia Tesei, Marco Ravegnini, Gloria Abbati, Francesca Rubino, Daniela Zamagni, Claudio D’Angelo, Emanuela De Iaco, Pierandrea Santini, Donatella Ceccarelli, Claudio Perrone, Anna Myriam Tallini, Giovanni de Biase, Dario De Leo, Antonio J Pers Med Article The molecular characterization of endometrial carcinoma (EC) has recently been included in the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice and the relevance of pathologic parameters in predicting prognosis in each EC molecular subgroup. ECs were classified using immunohistochemistry and next-generation sequencing into the four molecular classes: POLE mutant (POLE), mismatch repair deficient (MMRd), p53 mutant (p53abn), and no specific molecular profile (NSMP). According to the WHO algorithm, 219 ECs were subdivided into the following molecular subgroups: 7.8% POLE, 31% MMRd, 21% p53abn, 40.2% NSMP. Molecular classes as well as ESGO/ESTRO/ESP 2020 risk groups were statistically correlated with disease-free survival. Considering the impact of histopathologic features in each molecular class, stage was found to be the strongest prognostic factor in MMRd ECs, whereas in the p53abn subgroup, only lymph node status was associated with recurrent disease. Interestingly, in the NSMP tumor, several histopathologic features were correlated with recurrence: histotype, grade, stage, tumor necrosis, and substantial lymphovascular space invasion. Considering early-stage NSMP ECs, substantial lymphovascular space invasion was the only independent prognostic factor. Our study supports the prognostic importance of EC molecular classification and demonstrated the essential role of histopathologic assessment in patients’ management. MDPI 2023-04-25 /pmc/articles/PMC10219289/ /pubmed/37240893 http://dx.doi.org/10.3390/jpm13050723 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ruscelli, Martina
Maloberti, Thais
Corradini, Angelo Gianluca
Rosini, Francesca
Querzoli, Giulia
Grillini, Marco
Altimari, Annalisa
Gruppioni, Elisa
Sanza, Viviana
Costantino, Alessia
Ciudino, Riccardo
Errani, Matteo
Papapietro, Alessia
Coluccelli, Sara
Turchetti, Daniela
Ferioli, Martina
Giunchi, Susanna
Dondi, Giulia
Tesei, Marco
Ravegnini, Gloria
Abbati, Francesca
Rubino, Daniela
Zamagni, Claudio
D’Angelo, Emanuela
De Iaco, Pierandrea
Santini, Donatella
Ceccarelli, Claudio
Perrone, Anna Myriam
Tallini, Giovanni
de Biase, Dario
De Leo, Antonio
Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma
title Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma
title_full Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma
title_fullStr Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma
title_full_unstemmed Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma
title_short Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma
title_sort prognostic impact of pathologic features in molecular subgroups of endometrial carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219289/
https://www.ncbi.nlm.nih.gov/pubmed/37240893
http://dx.doi.org/10.3390/jpm13050723
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