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Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma
The molecular characterization of endometrial carcinoma (EC) has recently been included in the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice and the relevance of pathologic parameters in predicting...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219289/ https://www.ncbi.nlm.nih.gov/pubmed/37240893 http://dx.doi.org/10.3390/jpm13050723 |
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author | Ruscelli, Martina Maloberti, Thais Corradini, Angelo Gianluca Rosini, Francesca Querzoli, Giulia Grillini, Marco Altimari, Annalisa Gruppioni, Elisa Sanza, Viviana Costantino, Alessia Ciudino, Riccardo Errani, Matteo Papapietro, Alessia Coluccelli, Sara Turchetti, Daniela Ferioli, Martina Giunchi, Susanna Dondi, Giulia Tesei, Marco Ravegnini, Gloria Abbati, Francesca Rubino, Daniela Zamagni, Claudio D’Angelo, Emanuela De Iaco, Pierandrea Santini, Donatella Ceccarelli, Claudio Perrone, Anna Myriam Tallini, Giovanni de Biase, Dario De Leo, Antonio |
author_facet | Ruscelli, Martina Maloberti, Thais Corradini, Angelo Gianluca Rosini, Francesca Querzoli, Giulia Grillini, Marco Altimari, Annalisa Gruppioni, Elisa Sanza, Viviana Costantino, Alessia Ciudino, Riccardo Errani, Matteo Papapietro, Alessia Coluccelli, Sara Turchetti, Daniela Ferioli, Martina Giunchi, Susanna Dondi, Giulia Tesei, Marco Ravegnini, Gloria Abbati, Francesca Rubino, Daniela Zamagni, Claudio D’Angelo, Emanuela De Iaco, Pierandrea Santini, Donatella Ceccarelli, Claudio Perrone, Anna Myriam Tallini, Giovanni de Biase, Dario De Leo, Antonio |
author_sort | Ruscelli, Martina |
collection | PubMed |
description | The molecular characterization of endometrial carcinoma (EC) has recently been included in the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice and the relevance of pathologic parameters in predicting prognosis in each EC molecular subgroup. ECs were classified using immunohistochemistry and next-generation sequencing into the four molecular classes: POLE mutant (POLE), mismatch repair deficient (MMRd), p53 mutant (p53abn), and no specific molecular profile (NSMP). According to the WHO algorithm, 219 ECs were subdivided into the following molecular subgroups: 7.8% POLE, 31% MMRd, 21% p53abn, 40.2% NSMP. Molecular classes as well as ESGO/ESTRO/ESP 2020 risk groups were statistically correlated with disease-free survival. Considering the impact of histopathologic features in each molecular class, stage was found to be the strongest prognostic factor in MMRd ECs, whereas in the p53abn subgroup, only lymph node status was associated with recurrent disease. Interestingly, in the NSMP tumor, several histopathologic features were correlated with recurrence: histotype, grade, stage, tumor necrosis, and substantial lymphovascular space invasion. Considering early-stage NSMP ECs, substantial lymphovascular space invasion was the only independent prognostic factor. Our study supports the prognostic importance of EC molecular classification and demonstrated the essential role of histopathologic assessment in patients’ management. |
format | Online Article Text |
id | pubmed-10219289 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102192892023-05-27 Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma Ruscelli, Martina Maloberti, Thais Corradini, Angelo Gianluca Rosini, Francesca Querzoli, Giulia Grillini, Marco Altimari, Annalisa Gruppioni, Elisa Sanza, Viviana Costantino, Alessia Ciudino, Riccardo Errani, Matteo Papapietro, Alessia Coluccelli, Sara Turchetti, Daniela Ferioli, Martina Giunchi, Susanna Dondi, Giulia Tesei, Marco Ravegnini, Gloria Abbati, Francesca Rubino, Daniela Zamagni, Claudio D’Angelo, Emanuela De Iaco, Pierandrea Santini, Donatella Ceccarelli, Claudio Perrone, Anna Myriam Tallini, Giovanni de Biase, Dario De Leo, Antonio J Pers Med Article The molecular characterization of endometrial carcinoma (EC) has recently been included in the ESGO/ESTRO/ESP guidelines. The study aims to evaluate the impact of integrated molecular and pathologic risk stratification in the clinical practice and the relevance of pathologic parameters in predicting prognosis in each EC molecular subgroup. ECs were classified using immunohistochemistry and next-generation sequencing into the four molecular classes: POLE mutant (POLE), mismatch repair deficient (MMRd), p53 mutant (p53abn), and no specific molecular profile (NSMP). According to the WHO algorithm, 219 ECs were subdivided into the following molecular subgroups: 7.8% POLE, 31% MMRd, 21% p53abn, 40.2% NSMP. Molecular classes as well as ESGO/ESTRO/ESP 2020 risk groups were statistically correlated with disease-free survival. Considering the impact of histopathologic features in each molecular class, stage was found to be the strongest prognostic factor in MMRd ECs, whereas in the p53abn subgroup, only lymph node status was associated with recurrent disease. Interestingly, in the NSMP tumor, several histopathologic features were correlated with recurrence: histotype, grade, stage, tumor necrosis, and substantial lymphovascular space invasion. Considering early-stage NSMP ECs, substantial lymphovascular space invasion was the only independent prognostic factor. Our study supports the prognostic importance of EC molecular classification and demonstrated the essential role of histopathologic assessment in patients’ management. MDPI 2023-04-25 /pmc/articles/PMC10219289/ /pubmed/37240893 http://dx.doi.org/10.3390/jpm13050723 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ruscelli, Martina Maloberti, Thais Corradini, Angelo Gianluca Rosini, Francesca Querzoli, Giulia Grillini, Marco Altimari, Annalisa Gruppioni, Elisa Sanza, Viviana Costantino, Alessia Ciudino, Riccardo Errani, Matteo Papapietro, Alessia Coluccelli, Sara Turchetti, Daniela Ferioli, Martina Giunchi, Susanna Dondi, Giulia Tesei, Marco Ravegnini, Gloria Abbati, Francesca Rubino, Daniela Zamagni, Claudio D’Angelo, Emanuela De Iaco, Pierandrea Santini, Donatella Ceccarelli, Claudio Perrone, Anna Myriam Tallini, Giovanni de Biase, Dario De Leo, Antonio Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma |
title | Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma |
title_full | Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma |
title_fullStr | Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma |
title_full_unstemmed | Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma |
title_short | Prognostic Impact of Pathologic Features in Molecular Subgroups of Endometrial Carcinoma |
title_sort | prognostic impact of pathologic features in molecular subgroups of endometrial carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219289/ https://www.ncbi.nlm.nih.gov/pubmed/37240893 http://dx.doi.org/10.3390/jpm13050723 |
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