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Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense

One of the systems of plant defense against viral infection is RNA silencing, or RNA interference (RNAi), in which small RNAs derived from viral genomic RNAs and/or mRNAs serve as guides to target an Argonaute nuclease (AGO) to virus-specific RNAs. Complementary base pairing between the small interf...

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Autores principales: Atabekova, Anastasia K., Solovieva, Anna D., Chergintsev, Denis A., Solovyev, Andrey G., Morozov, Sergey Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219291/
https://www.ncbi.nlm.nih.gov/pubmed/37240394
http://dx.doi.org/10.3390/ijms24109049
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author Atabekova, Anastasia K.
Solovieva, Anna D.
Chergintsev, Denis A.
Solovyev, Andrey G.
Morozov, Sergey Y.
author_facet Atabekova, Anastasia K.
Solovieva, Anna D.
Chergintsev, Denis A.
Solovyev, Andrey G.
Morozov, Sergey Y.
author_sort Atabekova, Anastasia K.
collection PubMed
description One of the systems of plant defense against viral infection is RNA silencing, or RNA interference (RNAi), in which small RNAs derived from viral genomic RNAs and/or mRNAs serve as guides to target an Argonaute nuclease (AGO) to virus-specific RNAs. Complementary base pairing between the small interfering RNA incorporated into the AGO-based protein complex and viral RNA results in the target cleavage or translational repression. As a counter-defensive strategy, viruses have evolved to acquire viral silencing suppressors (VSRs) to inhibit the host plant RNAi pathway. Plant virus VSR proteins use multiple mechanisms to inhibit silencing. VSRs are often multifunctional proteins that perform additional functions in the virus infection cycle, particularly, cell-to-cell movement, genome encapsidation, or replication. This paper summarizes the available data on the proteins with dual VSR/movement protein activity used by plant viruses of nine orders to override the protective silencing response and reviews the different molecular mechanisms employed by these proteins to suppress RNAi.
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spelling pubmed-102192912023-05-27 Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense Atabekova, Anastasia K. Solovieva, Anna D. Chergintsev, Denis A. Solovyev, Andrey G. Morozov, Sergey Y. Int J Mol Sci Review One of the systems of plant defense against viral infection is RNA silencing, or RNA interference (RNAi), in which small RNAs derived from viral genomic RNAs and/or mRNAs serve as guides to target an Argonaute nuclease (AGO) to virus-specific RNAs. Complementary base pairing between the small interfering RNA incorporated into the AGO-based protein complex and viral RNA results in the target cleavage or translational repression. As a counter-defensive strategy, viruses have evolved to acquire viral silencing suppressors (VSRs) to inhibit the host plant RNAi pathway. Plant virus VSR proteins use multiple mechanisms to inhibit silencing. VSRs are often multifunctional proteins that perform additional functions in the virus infection cycle, particularly, cell-to-cell movement, genome encapsidation, or replication. This paper summarizes the available data on the proteins with dual VSR/movement protein activity used by plant viruses of nine orders to override the protective silencing response and reviews the different molecular mechanisms employed by these proteins to suppress RNAi. MDPI 2023-05-20 /pmc/articles/PMC10219291/ /pubmed/37240394 http://dx.doi.org/10.3390/ijms24109049 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Atabekova, Anastasia K.
Solovieva, Anna D.
Chergintsev, Denis A.
Solovyev, Andrey G.
Morozov, Sergey Y.
Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense
title Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense
title_full Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense
title_fullStr Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense
title_full_unstemmed Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense
title_short Role of Plant Virus Movement Proteins in Suppression of Host RNAi Defense
title_sort role of plant virus movement proteins in suppression of host rnai defense
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219291/
https://www.ncbi.nlm.nih.gov/pubmed/37240394
http://dx.doi.org/10.3390/ijms24109049
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