Association between Body Composition and the Risk of Portopulmonary Hypertension Assessed by Computed Tomography in Patients with Liver Cirrhosis

The aim of this study is to investigate the impact of body composition on the risk of portopulmonary hypertension using computed tomography (CT) in patients with liver cirrhosis. We retrospectively included 148 patients with cirrhosis treated at our hospital between March 2012 and December 2020. POP...

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Autores principales: Miwa, Takao, Hanai, Tatsunori, Nishimura, Kayoko, Tajirika, Satoko, Nakahata, Yuki, Imai, Kenji, Suetsugu, Atsushi, Takai, Koji, Yamamoto, Mayumi, Shimizu, Masahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219301/
https://www.ncbi.nlm.nih.gov/pubmed/37240457
http://dx.doi.org/10.3390/jcm12103351
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author Miwa, Takao
Hanai, Tatsunori
Nishimura, Kayoko
Tajirika, Satoko
Nakahata, Yuki
Imai, Kenji
Suetsugu, Atsushi
Takai, Koji
Yamamoto, Mayumi
Shimizu, Masahito
author_facet Miwa, Takao
Hanai, Tatsunori
Nishimura, Kayoko
Tajirika, Satoko
Nakahata, Yuki
Imai, Kenji
Suetsugu, Atsushi
Takai, Koji
Yamamoto, Mayumi
Shimizu, Masahito
author_sort Miwa, Takao
collection PubMed
description The aim of this study is to investigate the impact of body composition on the risk of portopulmonary hypertension using computed tomography (CT) in patients with liver cirrhosis. We retrospectively included 148 patients with cirrhosis treated at our hospital between March 2012 and December 2020. POPH high-risk was defined as main pulmonary artery diameter (mPA-D) ≥ 29 mm or mPA-D to ascending aorta diameter ratio ≥ 1.0, based on chest CT. Body composition was assessed using CT images of the third lumbar vertebra. The factors associated with POPH high-risk were evaluated using logistic regression and decision tree analyses, respectively. Among the 148 patients, 50% were females, and 31% were found to be high-risk cases on evaluation of chest CT images. Patients with a body mass index (BMI) of ≥25 mg/m(2) had a significantly higher prevalence of POPH high-risk than those with a BMI < 25 mg/m(2) (47% vs. 25%, p = 0.019). After adjusting for confounding factors, BMI (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.10–1.33), subcutaneous adipose tissue index (OR, 1.02; 95% CI, 1.01–1.03), and visceral adipose tissue index (OR, 1.03; 95% CI, 1.01–1.04) were associated with POPH high-risk, respectively. In the decision tree analysis, the strongest classifier of POPH high-risk was BMI, followed by the skeletal muscle index. Body composition may affect the risk of POPH based on chest CT assessment in patients with cirrhosis. Since the present study lacked data on right heart catheterization, further studies are required to confirm the results of our study.
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spelling pubmed-102193012023-05-27 Association between Body Composition and the Risk of Portopulmonary Hypertension Assessed by Computed Tomography in Patients with Liver Cirrhosis Miwa, Takao Hanai, Tatsunori Nishimura, Kayoko Tajirika, Satoko Nakahata, Yuki Imai, Kenji Suetsugu, Atsushi Takai, Koji Yamamoto, Mayumi Shimizu, Masahito J Clin Med Article The aim of this study is to investigate the impact of body composition on the risk of portopulmonary hypertension using computed tomography (CT) in patients with liver cirrhosis. We retrospectively included 148 patients with cirrhosis treated at our hospital between March 2012 and December 2020. POPH high-risk was defined as main pulmonary artery diameter (mPA-D) ≥ 29 mm or mPA-D to ascending aorta diameter ratio ≥ 1.0, based on chest CT. Body composition was assessed using CT images of the third lumbar vertebra. The factors associated with POPH high-risk were evaluated using logistic regression and decision tree analyses, respectively. Among the 148 patients, 50% were females, and 31% were found to be high-risk cases on evaluation of chest CT images. Patients with a body mass index (BMI) of ≥25 mg/m(2) had a significantly higher prevalence of POPH high-risk than those with a BMI < 25 mg/m(2) (47% vs. 25%, p = 0.019). After adjusting for confounding factors, BMI (odds ratio [OR], 1.21; 95% confidence interval [CI], 1.10–1.33), subcutaneous adipose tissue index (OR, 1.02; 95% CI, 1.01–1.03), and visceral adipose tissue index (OR, 1.03; 95% CI, 1.01–1.04) were associated with POPH high-risk, respectively. In the decision tree analysis, the strongest classifier of POPH high-risk was BMI, followed by the skeletal muscle index. Body composition may affect the risk of POPH based on chest CT assessment in patients with cirrhosis. Since the present study lacked data on right heart catheterization, further studies are required to confirm the results of our study. MDPI 2023-05-09 /pmc/articles/PMC10219301/ /pubmed/37240457 http://dx.doi.org/10.3390/jcm12103351 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Miwa, Takao
Hanai, Tatsunori
Nishimura, Kayoko
Tajirika, Satoko
Nakahata, Yuki
Imai, Kenji
Suetsugu, Atsushi
Takai, Koji
Yamamoto, Mayumi
Shimizu, Masahito
Association between Body Composition and the Risk of Portopulmonary Hypertension Assessed by Computed Tomography in Patients with Liver Cirrhosis
title Association between Body Composition and the Risk of Portopulmonary Hypertension Assessed by Computed Tomography in Patients with Liver Cirrhosis
title_full Association between Body Composition and the Risk of Portopulmonary Hypertension Assessed by Computed Tomography in Patients with Liver Cirrhosis
title_fullStr Association between Body Composition and the Risk of Portopulmonary Hypertension Assessed by Computed Tomography in Patients with Liver Cirrhosis
title_full_unstemmed Association between Body Composition and the Risk of Portopulmonary Hypertension Assessed by Computed Tomography in Patients with Liver Cirrhosis
title_short Association between Body Composition and the Risk of Portopulmonary Hypertension Assessed by Computed Tomography in Patients with Liver Cirrhosis
title_sort association between body composition and the risk of portopulmonary hypertension assessed by computed tomography in patients with liver cirrhosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219301/
https://www.ncbi.nlm.nih.gov/pubmed/37240457
http://dx.doi.org/10.3390/jcm12103351
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