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Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic
Introduction: The COVID-19 pandemic has changed the immunological status of the population, indicating increased activation. The aim of the study was to compare the degree of inflammatory activation in patients admitted for surgical revascularization in the period before and during the COVID-19 pand...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219314/ https://www.ncbi.nlm.nih.gov/pubmed/37233166 http://dx.doi.org/10.3390/jcdd10050199 |
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author | Urbanowicz, Tomasz Czub, Paweł Olasińska-Wiśniewska, Anna Michalak, Michał Fryska, Zuzanna Zieliński, Jakub Filipiak, Krzysztof Jerzy Wróbel, Krzysztof Tykarski, Andrzej Jemielity, Marek |
author_facet | Urbanowicz, Tomasz Czub, Paweł Olasińska-Wiśniewska, Anna Michalak, Michał Fryska, Zuzanna Zieliński, Jakub Filipiak, Krzysztof Jerzy Wróbel, Krzysztof Tykarski, Andrzej Jemielity, Marek |
author_sort | Urbanowicz, Tomasz |
collection | PubMed |
description | Introduction: The COVID-19 pandemic has changed the immunological status of the population, indicating increased activation. The aim of the study was to compare the degree of inflammatory activation in patients admitted for surgical revascularization in the period before and during the COVID-19 pandemic. Materials and methods: This retrospective analysis included an analysis of inflammatory activation assessed on the basis of whole blood counts in 533 patients (435 (82%) male and 98 (18%) female) with a median age of 66 (61–71) years who underwent surgical revascularization, including 343 and 190 patients operated on in 2018 and 2022, respectively. Results: The compared groups were matched by propensity score matching analysis, obtaining 190 patients in each group. Significantly higher values of preoperative monocyte count (p = 0.015), monocyte-to-lymphocyte ratio (p = 0.004) and systemic inflammatory response index (p = 0.022) were found in the during-COVID subgroup. The perioperative and 12-month mortality rates were comparable, with 1% (n = 4) in 2018 vs. 1% (n = 2) in 2022 (p = 0.911), and 5.6 % (n = 11 patients) vs. 7% (n = 13 patients) (p = 0.413), in the pre-COVID and during-COVID subgroups, respectively. Conclusions: Simple whole blood analysis in patients with complex coronary artery disease performed before and during the COVID-19 pandemic indicates excessive inflammatory activation. However, the immune variation did not interfere with one-year mortality rate after surgical revascularization. |
format | Online Article Text |
id | pubmed-10219314 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102193142023-05-27 Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic Urbanowicz, Tomasz Czub, Paweł Olasińska-Wiśniewska, Anna Michalak, Michał Fryska, Zuzanna Zieliński, Jakub Filipiak, Krzysztof Jerzy Wróbel, Krzysztof Tykarski, Andrzej Jemielity, Marek J Cardiovasc Dev Dis Article Introduction: The COVID-19 pandemic has changed the immunological status of the population, indicating increased activation. The aim of the study was to compare the degree of inflammatory activation in patients admitted for surgical revascularization in the period before and during the COVID-19 pandemic. Materials and methods: This retrospective analysis included an analysis of inflammatory activation assessed on the basis of whole blood counts in 533 patients (435 (82%) male and 98 (18%) female) with a median age of 66 (61–71) years who underwent surgical revascularization, including 343 and 190 patients operated on in 2018 and 2022, respectively. Results: The compared groups were matched by propensity score matching analysis, obtaining 190 patients in each group. Significantly higher values of preoperative monocyte count (p = 0.015), monocyte-to-lymphocyte ratio (p = 0.004) and systemic inflammatory response index (p = 0.022) were found in the during-COVID subgroup. The perioperative and 12-month mortality rates were comparable, with 1% (n = 4) in 2018 vs. 1% (n = 2) in 2022 (p = 0.911), and 5.6 % (n = 11 patients) vs. 7% (n = 13 patients) (p = 0.413), in the pre-COVID and during-COVID subgroups, respectively. Conclusions: Simple whole blood analysis in patients with complex coronary artery disease performed before and during the COVID-19 pandemic indicates excessive inflammatory activation. However, the immune variation did not interfere with one-year mortality rate after surgical revascularization. MDPI 2023-04-30 /pmc/articles/PMC10219314/ /pubmed/37233166 http://dx.doi.org/10.3390/jcdd10050199 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Urbanowicz, Tomasz Czub, Paweł Olasińska-Wiśniewska, Anna Michalak, Michał Fryska, Zuzanna Zieliński, Jakub Filipiak, Krzysztof Jerzy Wróbel, Krzysztof Tykarski, Andrzej Jemielity, Marek Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic |
title | Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic |
title_full | Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic |
title_fullStr | Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic |
title_full_unstemmed | Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic |
title_short | Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic |
title_sort | changing face of inflammatory activation in complex coronary artery disease during the covid-19 pandemic |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219314/ https://www.ncbi.nlm.nih.gov/pubmed/37233166 http://dx.doi.org/10.3390/jcdd10050199 |
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