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Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic

Introduction: The COVID-19 pandemic has changed the immunological status of the population, indicating increased activation. The aim of the study was to compare the degree of inflammatory activation in patients admitted for surgical revascularization in the period before and during the COVID-19 pand...

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Autores principales: Urbanowicz, Tomasz, Czub, Paweł, Olasińska-Wiśniewska, Anna, Michalak, Michał, Fryska, Zuzanna, Zieliński, Jakub, Filipiak, Krzysztof Jerzy, Wróbel, Krzysztof, Tykarski, Andrzej, Jemielity, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219314/
https://www.ncbi.nlm.nih.gov/pubmed/37233166
http://dx.doi.org/10.3390/jcdd10050199
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author Urbanowicz, Tomasz
Czub, Paweł
Olasińska-Wiśniewska, Anna
Michalak, Michał
Fryska, Zuzanna
Zieliński, Jakub
Filipiak, Krzysztof Jerzy
Wróbel, Krzysztof
Tykarski, Andrzej
Jemielity, Marek
author_facet Urbanowicz, Tomasz
Czub, Paweł
Olasińska-Wiśniewska, Anna
Michalak, Michał
Fryska, Zuzanna
Zieliński, Jakub
Filipiak, Krzysztof Jerzy
Wróbel, Krzysztof
Tykarski, Andrzej
Jemielity, Marek
author_sort Urbanowicz, Tomasz
collection PubMed
description Introduction: The COVID-19 pandemic has changed the immunological status of the population, indicating increased activation. The aim of the study was to compare the degree of inflammatory activation in patients admitted for surgical revascularization in the period before and during the COVID-19 pandemic. Materials and methods: This retrospective analysis included an analysis of inflammatory activation assessed on the basis of whole blood counts in 533 patients (435 (82%) male and 98 (18%) female) with a median age of 66 (61–71) years who underwent surgical revascularization, including 343 and 190 patients operated on in 2018 and 2022, respectively. Results: The compared groups were matched by propensity score matching analysis, obtaining 190 patients in each group. Significantly higher values of preoperative monocyte count (p = 0.015), monocyte-to-lymphocyte ratio (p = 0.004) and systemic inflammatory response index (p = 0.022) were found in the during-COVID subgroup. The perioperative and 12-month mortality rates were comparable, with 1% (n = 4) in 2018 vs. 1% (n = 2) in 2022 (p = 0.911), and 5.6 % (n = 11 patients) vs. 7% (n = 13 patients) (p = 0.413), in the pre-COVID and during-COVID subgroups, respectively. Conclusions: Simple whole blood analysis in patients with complex coronary artery disease performed before and during the COVID-19 pandemic indicates excessive inflammatory activation. However, the immune variation did not interfere with one-year mortality rate after surgical revascularization.
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spelling pubmed-102193142023-05-27 Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic Urbanowicz, Tomasz Czub, Paweł Olasińska-Wiśniewska, Anna Michalak, Michał Fryska, Zuzanna Zieliński, Jakub Filipiak, Krzysztof Jerzy Wróbel, Krzysztof Tykarski, Andrzej Jemielity, Marek J Cardiovasc Dev Dis Article Introduction: The COVID-19 pandemic has changed the immunological status of the population, indicating increased activation. The aim of the study was to compare the degree of inflammatory activation in patients admitted for surgical revascularization in the period before and during the COVID-19 pandemic. Materials and methods: This retrospective analysis included an analysis of inflammatory activation assessed on the basis of whole blood counts in 533 patients (435 (82%) male and 98 (18%) female) with a median age of 66 (61–71) years who underwent surgical revascularization, including 343 and 190 patients operated on in 2018 and 2022, respectively. Results: The compared groups were matched by propensity score matching analysis, obtaining 190 patients in each group. Significantly higher values of preoperative monocyte count (p = 0.015), monocyte-to-lymphocyte ratio (p = 0.004) and systemic inflammatory response index (p = 0.022) were found in the during-COVID subgroup. The perioperative and 12-month mortality rates were comparable, with 1% (n = 4) in 2018 vs. 1% (n = 2) in 2022 (p = 0.911), and 5.6 % (n = 11 patients) vs. 7% (n = 13 patients) (p = 0.413), in the pre-COVID and during-COVID subgroups, respectively. Conclusions: Simple whole blood analysis in patients with complex coronary artery disease performed before and during the COVID-19 pandemic indicates excessive inflammatory activation. However, the immune variation did not interfere with one-year mortality rate after surgical revascularization. MDPI 2023-04-30 /pmc/articles/PMC10219314/ /pubmed/37233166 http://dx.doi.org/10.3390/jcdd10050199 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Urbanowicz, Tomasz
Czub, Paweł
Olasińska-Wiśniewska, Anna
Michalak, Michał
Fryska, Zuzanna
Zieliński, Jakub
Filipiak, Krzysztof Jerzy
Wróbel, Krzysztof
Tykarski, Andrzej
Jemielity, Marek
Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic
title Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic
title_full Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic
title_fullStr Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic
title_full_unstemmed Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic
title_short Changing Face of Inflammatory Activation in Complex Coronary Artery Disease during the COVID-19 Pandemic
title_sort changing face of inflammatory activation in complex coronary artery disease during the covid-19 pandemic
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219314/
https://www.ncbi.nlm.nih.gov/pubmed/37233166
http://dx.doi.org/10.3390/jcdd10050199
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