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Alterations in the CD56(−) and CD56(+) T Cell Subsets during COVID-19

The effectiveness of the antiviral immune response largely depends on the activation of cytotoxic T cells. The heterogeneous group of functionally active T cells expressing the CD56 molecule (NKT-like cells), that combines the properties of T lymphocytes and NK cells, is poorly studied in COVID-19....

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Detalles Bibliográficos
Autores principales: Vavilova, Julia D., Ustiuzhanina, Maria O., Boyko, Anna A., Streltsova, Maria A., Kust, Sofya A., Kanevskiy, Leonid M., Iskhakov, Rustam N., Sapozhnikov, Alexander M., Gubernatorova, Ekaterina O., Drutskaya, Marina S., Bychinin, Mikhail V., Novikova, Oksana N., Sotnikova, Anna G., Yusubalieva, Gaukhar M., Baklaushev, Vladimir P., Kovalenko, Elena I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219320/
https://www.ncbi.nlm.nih.gov/pubmed/37240393
http://dx.doi.org/10.3390/ijms24109047
Descripción
Sumario:The effectiveness of the antiviral immune response largely depends on the activation of cytotoxic T cells. The heterogeneous group of functionally active T cells expressing the CD56 molecule (NKT-like cells), that combines the properties of T lymphocytes and NK cells, is poorly studied in COVID-19. This work aimed to analyze the activation and differentiation of both circulating NKT-like cells and CD56(−) T cells during COVID-19 among intensive care unit (ICU) patients, moderate severity (MS) patients, and convalescents. A decreased proportion of CD56(+) T cells was found in ICU patients with fatal outcome. Severe COVID-19 was accompanied by a decrease in the proportion of CD8(+) T cells, mainly due to the CD56(−) cell death, and a redistribution of the NKT-like cell subset composition with a predominance of more differentiated cytotoxic CD8(+) T cells. The differentiation process was accompanied by an increase in the proportions of KIR2DL2/3(+) and NKp30(+) cells in the CD56(+) T cell subset of COVID-19 patients and convalescents. Decreased percentages of NKG2D(+) and NKG2A(+) cells and increased PD-1 and HLA-DR expression levels were found in both CD56(−) and CD56(+) T cells, and can be considered as indicators of COVID-19 progression. In the CD56(−) T cell fraction, increased CD16 levels were observed in MS patients and in ICU patients with lethal outcome, suggesting a negative role for CD56(−)CD16(+) T cells in COVID-19. Overall, our findings suggest an antiviral role of CD56(+) T cells in COVID-19.