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Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides

Polyketides are a diverse set of natural products with versatile applications as pharmaceuticals, nutraceuticals, and cosmetics, to name a few. Of several types of polyketides, aromatic polyketides comprising type II and III polyketides contain many chemicals important for human health such as antib...

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Detalles Bibliográficos
Autores principales: Yang, Dongsoo, Eun, Hyunmin, Prabowo, Cindy Pricilia Surya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219323/
https://www.ncbi.nlm.nih.gov/pubmed/37240269
http://dx.doi.org/10.3390/ijms24108923
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author Yang, Dongsoo
Eun, Hyunmin
Prabowo, Cindy Pricilia Surya
author_facet Yang, Dongsoo
Eun, Hyunmin
Prabowo, Cindy Pricilia Surya
author_sort Yang, Dongsoo
collection PubMed
description Polyketides are a diverse set of natural products with versatile applications as pharmaceuticals, nutraceuticals, and cosmetics, to name a few. Of several types of polyketides, aromatic polyketides comprising type II and III polyketides contain many chemicals important for human health such as antibiotics and anticancer agents. Most aromatic polyketides are produced from soil bacteria or plants, which are difficult to engineer and grow slowly in industrial settings. To this end, metabolic engineering and synthetic biology have been employed to efficiently engineer heterologous model microorganisms for enhanced production of important aromatic polyketides. In this review, we discuss the recent advancement in metabolic engineering and synthetic biology strategies for the production of type II and type III polyketides in model microorganisms. Future challenges and prospects of aromatic polyketide biosynthesis by synthetic biology and enzyme engineering approaches are also discussed.
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spelling pubmed-102193232023-05-27 Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides Yang, Dongsoo Eun, Hyunmin Prabowo, Cindy Pricilia Surya Int J Mol Sci Review Polyketides are a diverse set of natural products with versatile applications as pharmaceuticals, nutraceuticals, and cosmetics, to name a few. Of several types of polyketides, aromatic polyketides comprising type II and III polyketides contain many chemicals important for human health such as antibiotics and anticancer agents. Most aromatic polyketides are produced from soil bacteria or plants, which are difficult to engineer and grow slowly in industrial settings. To this end, metabolic engineering and synthetic biology have been employed to efficiently engineer heterologous model microorganisms for enhanced production of important aromatic polyketides. In this review, we discuss the recent advancement in metabolic engineering and synthetic biology strategies for the production of type II and type III polyketides in model microorganisms. Future challenges and prospects of aromatic polyketide biosynthesis by synthetic biology and enzyme engineering approaches are also discussed. MDPI 2023-05-18 /pmc/articles/PMC10219323/ /pubmed/37240269 http://dx.doi.org/10.3390/ijms24108923 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Dongsoo
Eun, Hyunmin
Prabowo, Cindy Pricilia Surya
Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides
title Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides
title_full Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides
title_fullStr Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides
title_full_unstemmed Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides
title_short Metabolic Engineering and Synthetic Biology Approaches for the Heterologous Production of Aromatic Polyketides
title_sort metabolic engineering and synthetic biology approaches for the heterologous production of aromatic polyketides
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219323/
https://www.ncbi.nlm.nih.gov/pubmed/37240269
http://dx.doi.org/10.3390/ijms24108923
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