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Condition “Vasa Vasorum” in Patients with Thoracic Aortic Aneurysm

It is known that vasa vasorum contributes substantially to the blood supply and nutrition of one-third of the wall of the ascending thoracic aorta. Therefore, we focused on studying the relationship between inflammatory cells and vasa vasorum vessels in patients with aortic aneurysm. The material fo...

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Autores principales: Chumachenko, Petr V., Ivanova, Alexandra G., Bagheri Ekta, Mariam, Omelchenko, Andrey V., Sukhorukov, Vasily N., Markin, Alexander M., Markina, Yuliya V., Postnov, Anton Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219331/
https://www.ncbi.nlm.nih.gov/pubmed/37240684
http://dx.doi.org/10.3390/jcm12103578
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author Chumachenko, Petr V.
Ivanova, Alexandra G.
Bagheri Ekta, Mariam
Omelchenko, Andrey V.
Sukhorukov, Vasily N.
Markin, Alexander M.
Markina, Yuliya V.
Postnov, Anton Y.
author_facet Chumachenko, Petr V.
Ivanova, Alexandra G.
Bagheri Ekta, Mariam
Omelchenko, Andrey V.
Sukhorukov, Vasily N.
Markin, Alexander M.
Markina, Yuliya V.
Postnov, Anton Y.
author_sort Chumachenko, Petr V.
collection PubMed
description It is known that vasa vasorum contributes substantially to the blood supply and nutrition of one-third of the wall of the ascending thoracic aorta. Therefore, we focused on studying the relationship between inflammatory cells and vasa vasorum vessels in patients with aortic aneurysm. The material for the study was biopsies of thoracic aortic aneurysms taken from patients during an aneurysmectomy (34 men, 14 women, aged 33 to 79 years). The biopsies belonged to patients with non-hereditary thoracic aortic aneurysm. An immunohistochemical study was carried out using antibodies to antigens of T cells (CD3, CD4, CD8); macrophages (CD68); B cells (CD20); endothelium (CD31, CD34, von Willebrand factor (vWF)); and smooth muscle cells (alpha actin). Samples without inflammatory infiltrates contained less vasa vasorum in the tunica adventitia than samples with inflammatory infiltrates, and this difference was statistically significant p < 0.05. T cell infiltrates in the adventitia of aortic aneurysms were found in 28 of 48 patients. In the vessels of the vasa vasorum, surrounded by inflammatory infiltrates, T cells that adhered to the endothelium were found. The same cells were also localized in the subendothelial area. The number of adherent T cells in patients with inflammatory infiltrates in the aortic wall dominated the number of these cells in patients without inflammation of the aortic wall. This difference was statistically significant, p < 0.0006. Hypertrophy and sclerosis of the arteries of the vasa vasorum system, the narrowing of their lumen, and, as a result, impaired blood supply to the aortic wall, were found in 34 patients with hypertension. In 18 patients (both in patients with hypertension and in patients without hypertension), T cells that adhered to the vasa vasorum endothelium were found. In nine cases, massive infiltrates of T cells and macrophages were found, which surrounded and squeezed the vasa vasorum, preventing blood circulation. In six patients, parietal and obturating blood clots were found in the vasa vasorum vessels, which disrupted the normal blood supply to the aortic wall. We believe that this indicates the importance of the state of the vessels of the vasa vasorum in the development of an aortic aneurysm. In addition, pathological changes in these vessels may not always play a primary role, but always a very important role, in the pathogenesis of this disease.
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spelling pubmed-102193312023-05-27 Condition “Vasa Vasorum” in Patients with Thoracic Aortic Aneurysm Chumachenko, Petr V. Ivanova, Alexandra G. Bagheri Ekta, Mariam Omelchenko, Andrey V. Sukhorukov, Vasily N. Markin, Alexander M. Markina, Yuliya V. Postnov, Anton Y. J Clin Med Article It is known that vasa vasorum contributes substantially to the blood supply and nutrition of one-third of the wall of the ascending thoracic aorta. Therefore, we focused on studying the relationship between inflammatory cells and vasa vasorum vessels in patients with aortic aneurysm. The material for the study was biopsies of thoracic aortic aneurysms taken from patients during an aneurysmectomy (34 men, 14 women, aged 33 to 79 years). The biopsies belonged to patients with non-hereditary thoracic aortic aneurysm. An immunohistochemical study was carried out using antibodies to antigens of T cells (CD3, CD4, CD8); macrophages (CD68); B cells (CD20); endothelium (CD31, CD34, von Willebrand factor (vWF)); and smooth muscle cells (alpha actin). Samples without inflammatory infiltrates contained less vasa vasorum in the tunica adventitia than samples with inflammatory infiltrates, and this difference was statistically significant p < 0.05. T cell infiltrates in the adventitia of aortic aneurysms were found in 28 of 48 patients. In the vessels of the vasa vasorum, surrounded by inflammatory infiltrates, T cells that adhered to the endothelium were found. The same cells were also localized in the subendothelial area. The number of adherent T cells in patients with inflammatory infiltrates in the aortic wall dominated the number of these cells in patients without inflammation of the aortic wall. This difference was statistically significant, p < 0.0006. Hypertrophy and sclerosis of the arteries of the vasa vasorum system, the narrowing of their lumen, and, as a result, impaired blood supply to the aortic wall, were found in 34 patients with hypertension. In 18 patients (both in patients with hypertension and in patients without hypertension), T cells that adhered to the vasa vasorum endothelium were found. In nine cases, massive infiltrates of T cells and macrophages were found, which surrounded and squeezed the vasa vasorum, preventing blood circulation. In six patients, parietal and obturating blood clots were found in the vasa vasorum vessels, which disrupted the normal blood supply to the aortic wall. We believe that this indicates the importance of the state of the vessels of the vasa vasorum in the development of an aortic aneurysm. In addition, pathological changes in these vessels may not always play a primary role, but always a very important role, in the pathogenesis of this disease. MDPI 2023-05-20 /pmc/articles/PMC10219331/ /pubmed/37240684 http://dx.doi.org/10.3390/jcm12103578 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chumachenko, Petr V.
Ivanova, Alexandra G.
Bagheri Ekta, Mariam
Omelchenko, Andrey V.
Sukhorukov, Vasily N.
Markin, Alexander M.
Markina, Yuliya V.
Postnov, Anton Y.
Condition “Vasa Vasorum” in Patients with Thoracic Aortic Aneurysm
title Condition “Vasa Vasorum” in Patients with Thoracic Aortic Aneurysm
title_full Condition “Vasa Vasorum” in Patients with Thoracic Aortic Aneurysm
title_fullStr Condition “Vasa Vasorum” in Patients with Thoracic Aortic Aneurysm
title_full_unstemmed Condition “Vasa Vasorum” in Patients with Thoracic Aortic Aneurysm
title_short Condition “Vasa Vasorum” in Patients with Thoracic Aortic Aneurysm
title_sort condition “vasa vasorum” in patients with thoracic aortic aneurysm
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219331/
https://www.ncbi.nlm.nih.gov/pubmed/37240684
http://dx.doi.org/10.3390/jcm12103578
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