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The Role of Cold Atmospheric Plasma in Wound Healing Processes in Critically Ill Patients
Critically ill patients are at risk of skin wounds, which reduce their quality of life, complicate their pharmacological regimens, and prolong their hospital stays in intensive care units (ICUs), while also increasing overall mortality and morbidity rates. Cold atmospheric plasma (CAP) has been prop...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219374/ https://www.ncbi.nlm.nih.gov/pubmed/37240907 http://dx.doi.org/10.3390/jpm13050736 |
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author | Bolgeo, Tatiana Maconi, Antonio Gardalini, Menada Gatti, Denise Di Matteo, Roberta Lapidari, Marco Longhitano, Yaroslava Savioli, Gabriele Piccioni, Andrea Zanza, Christian |
author_facet | Bolgeo, Tatiana Maconi, Antonio Gardalini, Menada Gatti, Denise Di Matteo, Roberta Lapidari, Marco Longhitano, Yaroslava Savioli, Gabriele Piccioni, Andrea Zanza, Christian |
author_sort | Bolgeo, Tatiana |
collection | PubMed |
description | Critically ill patients are at risk of skin wounds, which reduce their quality of life, complicate their pharmacological regimens, and prolong their hospital stays in intensive care units (ICUs), while also increasing overall mortality and morbidity rates. Cold atmospheric plasma (CAP) has been proposed as a viable option for many biological and medical applications, given its capacity to reduce wound bacterial contamination and promote wound healing. The aim of this narrative review is to describe how CAP works and its operating mechanisms, as well as reporting its possible applications in critical care settings. The success of CAP in the treatment of wounds, in particular, bedsores or pressure sores, presents an innovative path in the prevention of nosocomial infections and an opportunity of reducing the negative implications of these diseases for the NHS. This narrative review of the literature was conducted following the ‘Scale for the Assessment of Narrative Review Articles’ (SANRA) methodology. Previous literature highlights three biological effects of plasma: inactivation of a wide range of microorganisms, including those that are multi-drug-resistant; increased cell proliferation and angiogenesis with a shorter period of plasma treatment; and apoptosis stimulation with a longer and more intensive treatment. CAP is effective in many areas of the medical field, with no significant adverse effects on healthy cells. However, its use can produce potentially serious side effects and should, therefore, be used under expert supervision and in appropriate doses. |
format | Online Article Text |
id | pubmed-10219374 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102193742023-05-27 The Role of Cold Atmospheric Plasma in Wound Healing Processes in Critically Ill Patients Bolgeo, Tatiana Maconi, Antonio Gardalini, Menada Gatti, Denise Di Matteo, Roberta Lapidari, Marco Longhitano, Yaroslava Savioli, Gabriele Piccioni, Andrea Zanza, Christian J Pers Med Review Critically ill patients are at risk of skin wounds, which reduce their quality of life, complicate their pharmacological regimens, and prolong their hospital stays in intensive care units (ICUs), while also increasing overall mortality and morbidity rates. Cold atmospheric plasma (CAP) has been proposed as a viable option for many biological and medical applications, given its capacity to reduce wound bacterial contamination and promote wound healing. The aim of this narrative review is to describe how CAP works and its operating mechanisms, as well as reporting its possible applications in critical care settings. The success of CAP in the treatment of wounds, in particular, bedsores or pressure sores, presents an innovative path in the prevention of nosocomial infections and an opportunity of reducing the negative implications of these diseases for the NHS. This narrative review of the literature was conducted following the ‘Scale for the Assessment of Narrative Review Articles’ (SANRA) methodology. Previous literature highlights three biological effects of plasma: inactivation of a wide range of microorganisms, including those that are multi-drug-resistant; increased cell proliferation and angiogenesis with a shorter period of plasma treatment; and apoptosis stimulation with a longer and more intensive treatment. CAP is effective in many areas of the medical field, with no significant adverse effects on healthy cells. However, its use can produce potentially serious side effects and should, therefore, be used under expert supervision and in appropriate doses. MDPI 2023-04-26 /pmc/articles/PMC10219374/ /pubmed/37240907 http://dx.doi.org/10.3390/jpm13050736 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bolgeo, Tatiana Maconi, Antonio Gardalini, Menada Gatti, Denise Di Matteo, Roberta Lapidari, Marco Longhitano, Yaroslava Savioli, Gabriele Piccioni, Andrea Zanza, Christian The Role of Cold Atmospheric Plasma in Wound Healing Processes in Critically Ill Patients |
title | The Role of Cold Atmospheric Plasma in Wound Healing Processes in Critically Ill Patients |
title_full | The Role of Cold Atmospheric Plasma in Wound Healing Processes in Critically Ill Patients |
title_fullStr | The Role of Cold Atmospheric Plasma in Wound Healing Processes in Critically Ill Patients |
title_full_unstemmed | The Role of Cold Atmospheric Plasma in Wound Healing Processes in Critically Ill Patients |
title_short | The Role of Cold Atmospheric Plasma in Wound Healing Processes in Critically Ill Patients |
title_sort | role of cold atmospheric plasma in wound healing processes in critically ill patients |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219374/ https://www.ncbi.nlm.nih.gov/pubmed/37240907 http://dx.doi.org/10.3390/jpm13050736 |
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