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Transvenous Pulmonary Chemoembolization and Optional Microwave Ablation for Colorectal Lung Metastases

(1) Purpose: To evaluate tumor response and survival of patients with colorectal pulmonary metastases treated by transvenous pulmonary chemoembolization (TPCE) alone with palliative intent or TPCE followed by microwave ablation (MWA) with potentially curative intent. (2) Material and methods: A tota...

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Autores principales: Vogl, Thomas J., Hammann, Lars, Adwan, Hamzah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219378/
https://www.ncbi.nlm.nih.gov/pubmed/37240500
http://dx.doi.org/10.3390/jcm12103394
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author Vogl, Thomas J.
Hammann, Lars
Adwan, Hamzah
author_facet Vogl, Thomas J.
Hammann, Lars
Adwan, Hamzah
author_sort Vogl, Thomas J.
collection PubMed
description (1) Purpose: To evaluate tumor response and survival of patients with colorectal pulmonary metastases treated by transvenous pulmonary chemoembolization (TPCE) alone with palliative intent or TPCE followed by microwave ablation (MWA) with potentially curative intent. (2) Material and methods: A total of 164 patients (64 women and 100 men; mean age: 61.8 ± 12.7 years) with unresectable colorectal lung metastases and not responding to systemic chemotherapy, who either received repetitive TPCE (Group A) or TPCE followed by MWA (Group B), were retrospectively enrolled. The revised response evaluation criteria in solid tumors were used to assess treatment response in Group A. The oncological response in Group B was divided into local tumor progression (LTP) and intrapulmonary distant recurrence (IDR) after MWA. (3) Results: The 1-, 2-, 3-, and 4-year survival rates were 70.4%, 41.4%, 22.3%, and 5%, respectively, for all patients. In Group A; the rates of stable disease; progressive disease; and partial response were at 55.4%, 41.9%, and 2.7%, respectively. The rates of LTP and IDR were 3.8%, and 63.5%, respectively, in Group B. Conclusion: TPCE is an effective treatment for colorectal lung metastases, which can be performed alone or combined with MWA.
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spelling pubmed-102193782023-05-27 Transvenous Pulmonary Chemoembolization and Optional Microwave Ablation for Colorectal Lung Metastases Vogl, Thomas J. Hammann, Lars Adwan, Hamzah J Clin Med Article (1) Purpose: To evaluate tumor response and survival of patients with colorectal pulmonary metastases treated by transvenous pulmonary chemoembolization (TPCE) alone with palliative intent or TPCE followed by microwave ablation (MWA) with potentially curative intent. (2) Material and methods: A total of 164 patients (64 women and 100 men; mean age: 61.8 ± 12.7 years) with unresectable colorectal lung metastases and not responding to systemic chemotherapy, who either received repetitive TPCE (Group A) or TPCE followed by MWA (Group B), were retrospectively enrolled. The revised response evaluation criteria in solid tumors were used to assess treatment response in Group A. The oncological response in Group B was divided into local tumor progression (LTP) and intrapulmonary distant recurrence (IDR) after MWA. (3) Results: The 1-, 2-, 3-, and 4-year survival rates were 70.4%, 41.4%, 22.3%, and 5%, respectively, for all patients. In Group A; the rates of stable disease; progressive disease; and partial response were at 55.4%, 41.9%, and 2.7%, respectively. The rates of LTP and IDR were 3.8%, and 63.5%, respectively, in Group B. Conclusion: TPCE is an effective treatment for colorectal lung metastases, which can be performed alone or combined with MWA. MDPI 2023-05-10 /pmc/articles/PMC10219378/ /pubmed/37240500 http://dx.doi.org/10.3390/jcm12103394 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vogl, Thomas J.
Hammann, Lars
Adwan, Hamzah
Transvenous Pulmonary Chemoembolization and Optional Microwave Ablation for Colorectal Lung Metastases
title Transvenous Pulmonary Chemoembolization and Optional Microwave Ablation for Colorectal Lung Metastases
title_full Transvenous Pulmonary Chemoembolization and Optional Microwave Ablation for Colorectal Lung Metastases
title_fullStr Transvenous Pulmonary Chemoembolization and Optional Microwave Ablation for Colorectal Lung Metastases
title_full_unstemmed Transvenous Pulmonary Chemoembolization and Optional Microwave Ablation for Colorectal Lung Metastases
title_short Transvenous Pulmonary Chemoembolization and Optional Microwave Ablation for Colorectal Lung Metastases
title_sort transvenous pulmonary chemoembolization and optional microwave ablation for colorectal lung metastases
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219378/
https://www.ncbi.nlm.nih.gov/pubmed/37240500
http://dx.doi.org/10.3390/jcm12103394
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