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Receptor–Ligand Binding: Effect of Mechanical Factors
Gaining insight into the in situ receptor–ligand binding is pivotal for revealing the molecular mechanisms underlying the physiological and pathological processes and will contribute to drug discovery and biomedical application. An important issue involved is how the receptor–ligand binding responds...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219515/ https://www.ncbi.nlm.nih.gov/pubmed/37240408 http://dx.doi.org/10.3390/ijms24109062 |
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author | Du, Ruotian Li, Long Ji, Jing Fan, Yubo |
author_facet | Du, Ruotian Li, Long Ji, Jing Fan, Yubo |
author_sort | Du, Ruotian |
collection | PubMed |
description | Gaining insight into the in situ receptor–ligand binding is pivotal for revealing the molecular mechanisms underlying the physiological and pathological processes and will contribute to drug discovery and biomedical application. An important issue involved is how the receptor–ligand binding responds to mechanical stimuli. This review aims to provide an overview of the current understanding of the effect of several representative mechanical factors, such as tension, shear stress, stretch, compression, and substrate stiffness on receptor–ligand binding, wherein the biomedical implications are focused. In addition, we highlight the importance of synergistic development of experimental and computational methods for fully understanding the in situ receptor–ligand binding, and further studies should focus on the coupling effects of these mechanical factors. |
format | Online Article Text |
id | pubmed-10219515 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102195152023-05-27 Receptor–Ligand Binding: Effect of Mechanical Factors Du, Ruotian Li, Long Ji, Jing Fan, Yubo Int J Mol Sci Review Gaining insight into the in situ receptor–ligand binding is pivotal for revealing the molecular mechanisms underlying the physiological and pathological processes and will contribute to drug discovery and biomedical application. An important issue involved is how the receptor–ligand binding responds to mechanical stimuli. This review aims to provide an overview of the current understanding of the effect of several representative mechanical factors, such as tension, shear stress, stretch, compression, and substrate stiffness on receptor–ligand binding, wherein the biomedical implications are focused. In addition, we highlight the importance of synergistic development of experimental and computational methods for fully understanding the in situ receptor–ligand binding, and further studies should focus on the coupling effects of these mechanical factors. MDPI 2023-05-21 /pmc/articles/PMC10219515/ /pubmed/37240408 http://dx.doi.org/10.3390/ijms24109062 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Du, Ruotian Li, Long Ji, Jing Fan, Yubo Receptor–Ligand Binding: Effect of Mechanical Factors |
title | Receptor–Ligand Binding: Effect of Mechanical Factors |
title_full | Receptor–Ligand Binding: Effect of Mechanical Factors |
title_fullStr | Receptor–Ligand Binding: Effect of Mechanical Factors |
title_full_unstemmed | Receptor–Ligand Binding: Effect of Mechanical Factors |
title_short | Receptor–Ligand Binding: Effect of Mechanical Factors |
title_sort | receptor–ligand binding: effect of mechanical factors |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219515/ https://www.ncbi.nlm.nih.gov/pubmed/37240408 http://dx.doi.org/10.3390/ijms24109062 |
work_keys_str_mv | AT duruotian receptorligandbindingeffectofmechanicalfactors AT lilong receptorligandbindingeffectofmechanicalfactors AT jijing receptorligandbindingeffectofmechanicalfactors AT fanyubo receptorligandbindingeffectofmechanicalfactors |