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Receptor–Ligand Binding: Effect of Mechanical Factors

Gaining insight into the in situ receptor–ligand binding is pivotal for revealing the molecular mechanisms underlying the physiological and pathological processes and will contribute to drug discovery and biomedical application. An important issue involved is how the receptor–ligand binding responds...

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Detalles Bibliográficos
Autores principales: Du, Ruotian, Li, Long, Ji, Jing, Fan, Yubo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219515/
https://www.ncbi.nlm.nih.gov/pubmed/37240408
http://dx.doi.org/10.3390/ijms24109062
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author Du, Ruotian
Li, Long
Ji, Jing
Fan, Yubo
author_facet Du, Ruotian
Li, Long
Ji, Jing
Fan, Yubo
author_sort Du, Ruotian
collection PubMed
description Gaining insight into the in situ receptor–ligand binding is pivotal for revealing the molecular mechanisms underlying the physiological and pathological processes and will contribute to drug discovery and biomedical application. An important issue involved is how the receptor–ligand binding responds to mechanical stimuli. This review aims to provide an overview of the current understanding of the effect of several representative mechanical factors, such as tension, shear stress, stretch, compression, and substrate stiffness on receptor–ligand binding, wherein the biomedical implications are focused. In addition, we highlight the importance of synergistic development of experimental and computational methods for fully understanding the in situ receptor–ligand binding, and further studies should focus on the coupling effects of these mechanical factors.
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spelling pubmed-102195152023-05-27 Receptor–Ligand Binding: Effect of Mechanical Factors Du, Ruotian Li, Long Ji, Jing Fan, Yubo Int J Mol Sci Review Gaining insight into the in situ receptor–ligand binding is pivotal for revealing the molecular mechanisms underlying the physiological and pathological processes and will contribute to drug discovery and biomedical application. An important issue involved is how the receptor–ligand binding responds to mechanical stimuli. This review aims to provide an overview of the current understanding of the effect of several representative mechanical factors, such as tension, shear stress, stretch, compression, and substrate stiffness on receptor–ligand binding, wherein the biomedical implications are focused. In addition, we highlight the importance of synergistic development of experimental and computational methods for fully understanding the in situ receptor–ligand binding, and further studies should focus on the coupling effects of these mechanical factors. MDPI 2023-05-21 /pmc/articles/PMC10219515/ /pubmed/37240408 http://dx.doi.org/10.3390/ijms24109062 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Du, Ruotian
Li, Long
Ji, Jing
Fan, Yubo
Receptor–Ligand Binding: Effect of Mechanical Factors
title Receptor–Ligand Binding: Effect of Mechanical Factors
title_full Receptor–Ligand Binding: Effect of Mechanical Factors
title_fullStr Receptor–Ligand Binding: Effect of Mechanical Factors
title_full_unstemmed Receptor–Ligand Binding: Effect of Mechanical Factors
title_short Receptor–Ligand Binding: Effect of Mechanical Factors
title_sort receptor–ligand binding: effect of mechanical factors
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219515/
https://www.ncbi.nlm.nih.gov/pubmed/37240408
http://dx.doi.org/10.3390/ijms24109062
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