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Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

The influence of gold nanoparticles after their prolonged oral administration to mice (during pregnancy and lactation) on spatial memory and anxiety levels in offspring was investigated. Offspring were tested in the Morris water maze and in the elevated Plus-maze. The average specific mass content o...

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Detalles Bibliográficos
Autores principales: Ivlieva, Alexandra L., Petritskaya, Elena N., Rogatkin, Dmitriy A., Zinicovscaia, Inga, Yushin, Nikita, Grozdov, Dmitrii
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219544/
https://www.ncbi.nlm.nih.gov/pubmed/37240304
http://dx.doi.org/10.3390/ijms24108962
Descripción
Sumario:The influence of gold nanoparticles after their prolonged oral administration to mice (during pregnancy and lactation) on spatial memory and anxiety levels in offspring was investigated. Offspring were tested in the Morris water maze and in the elevated Plus-maze. The average specific mass content of gold which crossed the blood–brain barrier was measured using neutron activation analysis and constituted 3.8 ng/g for females and 1.1 ng/g for offspring. Experimental offspring showed no differences in spatial orientation and memory compared to the control, while their anxiety levels increased. Gold nanoparticles influenced the emotional state of mice exposed to nanoparticles during prenatal and early postnatal development, but not their cognitive abilities.