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Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice
The influence of gold nanoparticles after their prolonged oral administration to mice (during pregnancy and lactation) on spatial memory and anxiety levels in offspring was investigated. Offspring were tested in the Morris water maze and in the elevated Plus-maze. The average specific mass content o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219544/ https://www.ncbi.nlm.nih.gov/pubmed/37240304 http://dx.doi.org/10.3390/ijms24108962 |
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author | Ivlieva, Alexandra L. Petritskaya, Elena N. Rogatkin, Dmitriy A. Zinicovscaia, Inga Yushin, Nikita Grozdov, Dmitrii |
author_facet | Ivlieva, Alexandra L. Petritskaya, Elena N. Rogatkin, Dmitriy A. Zinicovscaia, Inga Yushin, Nikita Grozdov, Dmitrii |
author_sort | Ivlieva, Alexandra L. |
collection | PubMed |
description | The influence of gold nanoparticles after their prolonged oral administration to mice (during pregnancy and lactation) on spatial memory and anxiety levels in offspring was investigated. Offspring were tested in the Morris water maze and in the elevated Plus-maze. The average specific mass content of gold which crossed the blood–brain barrier was measured using neutron activation analysis and constituted 3.8 ng/g for females and 1.1 ng/g for offspring. Experimental offspring showed no differences in spatial orientation and memory compared to the control, while their anxiety levels increased. Gold nanoparticles influenced the emotional state of mice exposed to nanoparticles during prenatal and early postnatal development, but not their cognitive abilities. |
format | Online Article Text |
id | pubmed-10219544 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-102195442023-05-27 Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice Ivlieva, Alexandra L. Petritskaya, Elena N. Rogatkin, Dmitriy A. Zinicovscaia, Inga Yushin, Nikita Grozdov, Dmitrii Int J Mol Sci Communication The influence of gold nanoparticles after their prolonged oral administration to mice (during pregnancy and lactation) on spatial memory and anxiety levels in offspring was investigated. Offspring were tested in the Morris water maze and in the elevated Plus-maze. The average specific mass content of gold which crossed the blood–brain barrier was measured using neutron activation analysis and constituted 3.8 ng/g for females and 1.1 ng/g for offspring. Experimental offspring showed no differences in spatial orientation and memory compared to the control, while their anxiety levels increased. Gold nanoparticles influenced the emotional state of mice exposed to nanoparticles during prenatal and early postnatal development, but not their cognitive abilities. MDPI 2023-05-18 /pmc/articles/PMC10219544/ /pubmed/37240304 http://dx.doi.org/10.3390/ijms24108962 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Communication Ivlieva, Alexandra L. Petritskaya, Elena N. Rogatkin, Dmitriy A. Zinicovscaia, Inga Yushin, Nikita Grozdov, Dmitrii Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice |
title | Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice |
title_full | Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice |
title_fullStr | Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice |
title_full_unstemmed | Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice |
title_short | Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice |
title_sort | impact of chronic oral administration of gold nanoparticles on cognitive abilities of mice |
topic | Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219544/ https://www.ncbi.nlm.nih.gov/pubmed/37240304 http://dx.doi.org/10.3390/ijms24108962 |
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