Cargando…

Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice

The influence of gold nanoparticles after their prolonged oral administration to mice (during pregnancy and lactation) on spatial memory and anxiety levels in offspring was investigated. Offspring were tested in the Morris water maze and in the elevated Plus-maze. The average specific mass content o...

Descripción completa

Detalles Bibliográficos
Autores principales: Ivlieva, Alexandra L., Petritskaya, Elena N., Rogatkin, Dmitriy A., Zinicovscaia, Inga, Yushin, Nikita, Grozdov, Dmitrii
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219544/
https://www.ncbi.nlm.nih.gov/pubmed/37240304
http://dx.doi.org/10.3390/ijms24108962
_version_ 1785049035063689216
author Ivlieva, Alexandra L.
Petritskaya, Elena N.
Rogatkin, Dmitriy A.
Zinicovscaia, Inga
Yushin, Nikita
Grozdov, Dmitrii
author_facet Ivlieva, Alexandra L.
Petritskaya, Elena N.
Rogatkin, Dmitriy A.
Zinicovscaia, Inga
Yushin, Nikita
Grozdov, Dmitrii
author_sort Ivlieva, Alexandra L.
collection PubMed
description The influence of gold nanoparticles after their prolonged oral administration to mice (during pregnancy and lactation) on spatial memory and anxiety levels in offspring was investigated. Offspring were tested in the Morris water maze and in the elevated Plus-maze. The average specific mass content of gold which crossed the blood–brain barrier was measured using neutron activation analysis and constituted 3.8 ng/g for females and 1.1 ng/g for offspring. Experimental offspring showed no differences in spatial orientation and memory compared to the control, while their anxiety levels increased. Gold nanoparticles influenced the emotional state of mice exposed to nanoparticles during prenatal and early postnatal development, but not their cognitive abilities.
format Online
Article
Text
id pubmed-10219544
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-102195442023-05-27 Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice Ivlieva, Alexandra L. Petritskaya, Elena N. Rogatkin, Dmitriy A. Zinicovscaia, Inga Yushin, Nikita Grozdov, Dmitrii Int J Mol Sci Communication The influence of gold nanoparticles after their prolonged oral administration to mice (during pregnancy and lactation) on spatial memory and anxiety levels in offspring was investigated. Offspring were tested in the Morris water maze and in the elevated Plus-maze. The average specific mass content of gold which crossed the blood–brain barrier was measured using neutron activation analysis and constituted 3.8 ng/g for females and 1.1 ng/g for offspring. Experimental offspring showed no differences in spatial orientation and memory compared to the control, while their anxiety levels increased. Gold nanoparticles influenced the emotional state of mice exposed to nanoparticles during prenatal and early postnatal development, but not their cognitive abilities. MDPI 2023-05-18 /pmc/articles/PMC10219544/ /pubmed/37240304 http://dx.doi.org/10.3390/ijms24108962 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Ivlieva, Alexandra L.
Petritskaya, Elena N.
Rogatkin, Dmitriy A.
Zinicovscaia, Inga
Yushin, Nikita
Grozdov, Dmitrii
Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice
title Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice
title_full Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice
title_fullStr Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice
title_full_unstemmed Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice
title_short Impact of Chronic Oral Administration of Gold Nanoparticles on Cognitive Abilities of Mice
title_sort impact of chronic oral administration of gold nanoparticles on cognitive abilities of mice
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219544/
https://www.ncbi.nlm.nih.gov/pubmed/37240304
http://dx.doi.org/10.3390/ijms24108962
work_keys_str_mv AT ivlievaalexandral impactofchronicoraladministrationofgoldnanoparticlesoncognitiveabilitiesofmice
AT petritskayaelenan impactofchronicoraladministrationofgoldnanoparticlesoncognitiveabilitiesofmice
AT rogatkindmitriya impactofchronicoraladministrationofgoldnanoparticlesoncognitiveabilitiesofmice
AT zinicovscaiainga impactofchronicoraladministrationofgoldnanoparticlesoncognitiveabilitiesofmice
AT yushinnikita impactofchronicoraladministrationofgoldnanoparticlesoncognitiveabilitiesofmice
AT grozdovdmitrii impactofchronicoraladministrationofgoldnanoparticlesoncognitiveabilitiesofmice