CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages

An intense, nonresolving airway inflammatory response leads to destructive lung disease in cystic fibrosis (CF). Dysregulation of macrophage immune function may be a key facet governing the progression of CF lung disease, but the underlying mechanisms are not fully understood. We used 5′ end centere...

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Detalles Bibliográficos
Autores principales: Gillan, Jonathan L., Chokshi, Mithil, Hardisty, Gareth R., Clohisey Hendry, Sara, Prasca-Chamorro, Daniel, Robinson, Nicola J., Lasota, Benjamin, Clark, Richard, Murphy, Lee, Whyte, Moira K. B., Baillie, J. Kenneth, Davidson, Donald J., Bao, Gang, Gray, Robert D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219589/
https://www.ncbi.nlm.nih.gov/pubmed/37235648
http://dx.doi.org/10.1126/sciadv.adg5128

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