Cargando…

Secreted endogenous macrosomes reduce Aβ burden and ameliorate Alzheimer’s disease

Innovative therapeutic strategies are urgently needed for Alzheimer’s disease (AD) due to the increasing size of the aging population and the lack of effective drug treatment. Here, we report the therapeutic effects of extracellular vesicles (EVs) secreted by microglia, including macrosomes and smal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Cunli, Yang, Yiming, Zhang, Xiaoyu, Shi, Zhenqiang, Gao, Huiling, Zhong, Manli, Fan, Yonggang, Zhang, Hongyan, Liu, Bo, Qing, Guangyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219594/ https://www.ncbi.nlm.nih.gov/pubmed/37235655 http://dx.doi.org/10.1126/sciadv.ade0293

Ejemplares similares

Maternal and neonatal outcomes of macrosomic pregnancies
por: Weissmann-Brenner, Alina, et al.
Publicado: (2012)

Phage display derived peptides for Alzheimer's disease therapy and diagnosis
por: Zhang, Xiancheng, et al.
Publicado: (2022)

Infant feeding practices among macrosomic infants: A prospective cohort study
por: Davie, Philippa, et al.
Publicado: (2021)

Th1/Th2 Dichotomy in Obese Women with Gestational Diabetes and Their Macrosomic Babies
por: Seck, A., et al.
Publicado: (2018)

Microsomic and macrosomic body structure in children and adolescents affected by syndromes or diseases associated with neurodysfunction
por: Perenc, Lidia, et al.
Publicado: (2021)

Postpartum Metabolic Function in Women Delivering a Macrosomic Infant in the Absence of Gestational Diabetes Mellitus
por: Kew, Simone, et al.
Publicado: (2011)

Macrosomic Births in a Tertiary Public Hospital: A Survey of Maternal Characteristics and Fetal Outcome
por: Osaikhuwuomwan, James, et al.
Publicado: (2016)

Pregnancy outcomes in relation to different types of diabetes mellitus and modes of delivery in macrosomic foetuses in Bahrain
por: Al Omran, Bedoor S., et al.
Publicado: (2016)

The risk of diabetes after giving birth to a macrosomic infant: data from the NHANES cohort
por: Miller, Corrie, et al.
Publicado: (2021)

Disadvantages of a weight estimation formula for macrosomic fetuses: the Hart formula from a clinical perspective
por: Weiss, Christoph, et al.
Publicado: (2018)

Predictability of Macrosomic Birth based on Maternal Factors and Fetal Aneuploidy Screening Biochemical Markers in Hyperglycemic Mothers
por: Hur, Junguk, et al.
Publicado: (2021)

Effect of Dietary n − 3 Polyunsaturated Fatty Acids on Oxidant/Antioxidant Status in Macrosomic Offspring of Diabetic Rats
por: Guermouche, B., et al.
Publicado: (2014)

Peptidome analysis of human milk from women delivering macrosomic fetuses reveals multiple means of protection for infants
por: Cui, Xianwei, et al.
Publicado: (2016)

Does the Porter formula hold its promise? A weight estimation formula for macrosomic fetuses put to the test
por: Weiss, Christoph, et al.
Publicado: (2019)

A predictive model of macrosomic birth based upon real-world clinical data from pregnant women
por: Jing, Gao, et al.
Publicado: (2022)

Trends in the Prevalence of Live Macrosomic Newborns According to Gestational Age Strata, in Brazil, 2001–2010, and 2012–2014
por: Nascimento, Maria Isabel do, et al.
Publicado: (2017)

History of Having a Macrosomic Infant and the Risk of Diabetes: The Japan Public Health Center-Based Prospective Diabetes Study
por: Kabeya, Yusuke, et al.
Publicado: (2013)

Interpregnancy weight changes and impact on pregnancy outcome in a cohort of women with a macrosomic first delivery: a prospective longitudinal study
por: Crosby, David A, et al.
Publicado: (2017)

SUN-270 Heterozygous Mutation in ABCC8 in a Pedigree with Congenital Hyperinsulinism, Multiple Macrosomic Stillbirths, and Adult-Onset Diabetes Mellitus
por: Ludwig, Karissa, et al.
Publicado: (2019)

Advances in Alzheimer’s Disease-Associated Aβ Therapy Based on Peptide
por: Wang, Cunli, et al.
Publicado: (2023)

Ameliorating effect of luteolin on memory impairment in an Alzheimer's disease model
por: WANG, HUIMIN, et al.
Publicado: (2016)

循环肿瘤细胞捕获材料的研究进展
por: SUN, Wenjing, et al.
Publicado: (2021)

Macrosomic Neonates Carry Increased Risk of Dental Caries in Early Childhood: Findings from a Cohort Study, the Okinawa Child Health Study, Japan
por: Yokomichi, Hiroshi, et al.
Publicado: (2015)

Secret messaging with endogenous chemistry
por: Kennedy, Eamonn, et al.
Publicado: (2021)

Nasal Delivery of D-Penicillamine Hydrogel Upregulates a Disintegrin and Metalloprotease 10 Expression via Melatonin Receptor 1 in Alzheimer’s Disease Models
por: Zhong, Manli, et al.
Publicado: (2021)

A Novel Cu(II)-Binding Peptide Identified by Phage Display Inhibits Cu(2+)-Mediated Aβ Aggregation
por: Zhang, Xiaoyu, et al.
Publicado: (2021)

Novel nanoporous covalent organic frameworks for the selective extraction of endogenous peptides
por: Zhang, Xiaofei, et al.
Publicado: (2018)

Differential Expression of Glucose Transporter Proteins GLUT-1, GLUT-3, GLUT-8 and GLUT-12 in the Placenta of Macrosomic, Small-for-Gestational-Age and Growth-Restricted Foetuses
por: Stanirowski, Paweł Jan, et al.
Publicado: (2021)

Osteocalcin ameliorates cognitive dysfunctions in a mouse model of Alzheimer’s Disease by reducing amyloid β burden and upregulating glycolysis in neuroglia
por: Shan, Chang, et al.
Publicado: (2023)

Clusterin secreted from astrocyte promotes excitatory synaptic transmission and ameliorates Alzheimer’s disease neuropathology
por: Chen, Fading, et al.
Publicado: (2021)

Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis
por: Cai, Yawen, et al.
Publicado: (2022)

Icariin Ameliorates Lower Back Pain in Rats via Suppressing the Secretion of Cytokine-Induced Neutrophil Chemoatractant-1
por: Li, Jitian, et al.
Publicado: (2020)

Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin
por: Iida, Atsushi, et al.
Publicado: (2016)

Xanthoceraside Could Ameliorate Alzheimer’s Disease Symptoms of Rats by Affecting the Gut Microbiota Composition and Modulating the Endogenous Metabolite Levels
por: Zhou, Hongxu, et al.
Publicado: (2019)

Endogenous insulin secretion in critically ill patients
por: Pretty, C, et al.
Publicado: (2012)

The structure of the endogenous ESX-3 secretion system
por: Poweleit, Nicole, et al.
Publicado: (2019)

Effective Delivery of Endogenous Antioxidants Ameliorates Diabetic Nephropathy
por: Park, Yongsoo, et al.
Publicado: (2015)

Neuroprotective Effects of Higenamine Against the Alzheimer’s Disease Via Amelioration of Cognitive Impairment, Aβ Burden, Apoptosis and Regulation of Akt/GSK3β Signaling Pathway
por: Yang, Xiaona, et al.
Publicado: (2020)

The α-mating factor secretion signals and endogenous signal peptides for recombinant protein secretion in Komagataella phaffii
por: Zou, Chenwei, et al.
Publicado: (2022)

Bibliometric review on sleep and Alzheimer disease between 1986 and 2023
por: Sun, Xiaoyu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_urv0t301bnc8bmjgj0rtdsrv2h