Increased 3-O-sulfated heparan sulfate in Alzheimer’s disease brain is associated with genetic risk gene HS3ST1

HS3ST1 is a genetic risk gene associated with Alzheimer’s disease (AD) and overexpressed in patients, but how it contributes to the disease progression is unknown. We report the analysis of brain heparan sulfate (HS) from AD and other tauopathies using a LC-MS/MS method. A specific 3-O-sulfated HS d...

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Detalles Bibliográficos
Autores principales: Wang, Zhangjie, Patel, Vaishali N., Song, Xuehong, Xu, Yongmei, Kaminski, Andrea M., Doan, Vivien Uyen, Su, Guowei, Liao, Yien, Mah, Dylan, Zhang, Fuming, Pagadala, Vijayakanth, Wang, Chunyu, Pedersen, Lars C., Wang, Lianchun, Hoffman, Matthew P., Gearing, Marla, Liu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219595/
https://www.ncbi.nlm.nih.gov/pubmed/37235665
http://dx.doi.org/10.1126/sciadv.adf6232

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