Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy

Sepsis-associated encephalopathy (SAE) is a severe and frequent complication of sepsis causing delirium, coma, and long-term cognitive dysfunction. We identified microglia and C1q complement activation in hippocampal autopsy tissue of patients with sepsis and increased C1q-mediated synaptic pruning...

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Detalles Bibliográficos
Autores principales: Chung, Ha-Yeun, Wickel, Jonathan, Hahn, Nina, Mein, Nils, Schwarzbrunn, Meike, Koch, Philipp, Ceanga, Mihai, Haselmann, Holger, Baade-Büttner, Carolin, von Stackelberg, Nikolai, Hempel, Nina, Schmidl, Lars, Groth, Marco, Andreas, Nico, Götze, Juliane, Coldewey, Sina M., Bauer, Michael, Mawrin, Christian, Dargvainiene, Justina, Leypoldt, Frank, Steinke, Stephan, Wang, Zhao-Qi, Hust, Michael, Geis, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219600/
https://www.ncbi.nlm.nih.gov/pubmed/37235660
http://dx.doi.org/10.1126/sciadv.abq7806

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