Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity

PURPOSE: The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity. METHODS: Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was i...

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Autores principales: Christensen, Anders, Wessel, Irene, Charabi, Birgitte Wittenborg, Juhl, Karina, Kiss, Katalin, Lelkaitis, Giedrius, Mortensen, Jann, Kjaer, Andreas, von Buchwald, Christian, Tvedskov, Jesper Filtenborg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Head and Neck
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219873/
https://www.ncbi.nlm.nih.gov/pubmed/37010601
http://dx.doi.org/10.1007/s00405-023-07939-5
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author Christensen, Anders
Wessel, Irene
Charabi, Birgitte Wittenborg
Juhl, Karina
Kiss, Katalin
Lelkaitis, Giedrius
Mortensen, Jann
Kjaer, Andreas
von Buchwald, Christian
Tvedskov, Jesper Filtenborg
author_facet Christensen, Anders
Wessel, Irene
Charabi, Birgitte Wittenborg
Juhl, Karina
Kiss, Katalin
Lelkaitis, Giedrius
Mortensen, Jann
Kjaer, Andreas
von Buchwald, Christian
Tvedskov, Jesper Filtenborg
author_sort Christensen, Anders
collection PubMed
description PURPOSE: The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity. METHODS: Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up. RESULTS: In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%. CONCLUSION: Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection.
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spelling pubmed-102198732023-05-28 Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity Christensen, Anders Wessel, Irene Charabi, Birgitte Wittenborg Juhl, Karina Kiss, Katalin Lelkaitis, Giedrius Mortensen, Jann Kjaer, Andreas von Buchwald, Christian Tvedskov, Jesper Filtenborg Eur Arch Otorhinolaryngol Head and Neck PURPOSE: The purpose was to investigate the diagnostic performance of bimodal optical and radio-guided sentinel node biopsy (SNB) for oral squamous cell carcinoma (OSCC) sub-sites in the anterior oral cavity. METHODS: Prospective study of 50 consecutive patients with cN0 OSCC scheduled for SNB was injected with the tracer complex Tc99m:ICG:Nacocoll. A near-infrared camera was applied for optical SN detection. Endpoints were modality for intraoperative SN detection and false omission rate at follow-up. RESULTS: In all patients, a SN could be detected. In 12/50 (24%) of cases, the SPECT/CT showed no focus in level 1, but intraoperatively a SN in level 1 was optically detected. In 22/50 cases (44%), an additional SN was identified only due to the optical imaging. At follow-up, the false omission rate was 0%. CONCLUSION: Optical imaging appears to be an effective tool to allow real-time SN identification comprising level 1 unaffected by possible interference of radiation site from the injection. Springer Berlin Heidelberg 2023-04-03 2023 /pmc/articles/PMC10219873/ /pubmed/37010601 http://dx.doi.org/10.1007/s00405-023-07939-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Head and Neck
Christensen, Anders
Wessel, Irene
Charabi, Birgitte Wittenborg
Juhl, Karina
Kiss, Katalin
Lelkaitis, Giedrius
Mortensen, Jann
Kjaer, Andreas
von Buchwald, Christian
Tvedskov, Jesper Filtenborg
Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity
title Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity
title_full Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity
title_fullStr Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity
title_full_unstemmed Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity
title_short Diagnostic accuracy of combined optical- and radio-guided SNB for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity
title_sort diagnostic accuracy of combined optical- and radio-guided snb for neck staging of oral squamous cell carcinoma lesions in the anterior oral cavity
topic Head and Neck
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10219873/
https://www.ncbi.nlm.nih.gov/pubmed/37010601
http://dx.doi.org/10.1007/s00405-023-07939-5
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