TRABID inhibition activates cGAS/STING-mediated anti-tumor immunity through mitosis and autophagy dysregulation

Activation of tumor-intrinsic innate immunity has been a major strategy for improving immunotherapy. Previously, we reported an autophagy-promoting function of the deubiquitinating enzyme TRABID. Here, we identify a critical role of TRABID in suppressing anti-tumor immunity. Mechanistically, TRABID...

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Detalles Bibliográficos
Autores principales: Chen, Yu-Hsuan, Chen, Han-Hsiun, Wang, Won-Jing, Chen, Hsin-Yi, Huang, Wei-Syun, Kao, Chien-Han, Lee, Sin-Rong, Yeat, Nai Yang, Yan, Ruei-Liang, Chan, Shu-Jou, Wu, Kuen-Phon, Chen, Ruey-Hwa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10220035/
https://www.ncbi.nlm.nih.gov/pubmed/37237031
http://dx.doi.org/10.1038/s41467-023-38784-z

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